Spatial-spectral mapping to prepare frequency entangled qudits.

Entangled qudits, the high-dimensional entangled states, play an important role in the study of quantum information. How to prepare entangled qudits in an efficient and easy-to-operate manner is still a challenge in quantum technology. Here, we demonstrate a method to engineer frequency entangled qudits in a spontaneous parametric downconversion process. The proposal employs an angle-dependent phase-matching condition in a nonlinear crystal, which forms a classical-quantum mapping between the spatial (pump) and spectral (biphotons) degrees of freedom. In particular, the pump profile is separated into several bins in the spatial domain, and thus shapes the down-converted biphotons into discrete frequency modes in the joint spectral space. Our approach provides a feasible and efficient method to prepare a high-dimensional frequency entangled state. As an experimental demonstration, we generate a three-dimensional entangled state by using a homemade variable slit mask.

Observation of Anomalous Orbital Angular Momentum Transfer in Parametric Nonlinearity.

Orbital angular momentum (OAM) conservation plays an important role in shaping and controlling structured light with nonlinear optics. The OAM of a beam originating from three-wave mixing should be the sum or difference of the other two inputs because no light-matter OAM exchange occurs in parametric nonlinear interactions. Here, we report anomalous OAM transfer in parametric upconversion, in which a Hermite-Gauss mode signal interacts with a specially engineered pump capable of astigmatic transformation, resulting in Laguerre-Gaussian mode sum-frequency generation (SFG). The anomaly here refers to the fact that the pump and signal both carry no net OAM, while their SFG does. We reveal experimentally that there is also an OAM inflow to the residual pump, having the same amount of that to the SFG but with the opposite sign, and thus holds system OAM conservation. This unexpected OAM selection rule improves our understanding of OAM transfer among interacting waves and may inspire new ideas for controlling OAM states via nonlinear optics.

Hot Carrier Lifetimes and Electrochemical Water Dissociation Enhanced by Nickel Doping of a Plasmonic Electrocatalyst.

Hot carriers generated by localized surface plasmon resonance (LSPR) excitation of plasmonic metal nanoparticles are known to enhance electrocatalytic reactions. However, the participation of plasmonically generated carriers in interfacial electrochemical reactions is often limited by fast relaxation of these carriers. Herein, we address this challenge by tuning the electronic structure of a plasmonic electrocatalyst. Specifically, we design an electrocatalyst for alkaline hydrogen evolution reaction (HER) that consists of nanoparticles of a ternary Cu-Pt-Ni ternary alloy. The CuPt alloy has both plasmonic attributes and electrocatalytic HER activity. Ni doping contributes an electron-deficient 3d band and fully filled 4s band, which promotes water adsorption and prolongs the lifetimes of excited carriers generated by plasmonic excitation. As an outcome, the Cu-Pt-Ni nanoparticles exhibit boosted activity for electrochemical water dissociation and HER under LSPR excitation.

Metal and metalloid sources apportionment in soil of two major agroecosystems of southern China.

Apportioning the sources of metals/metalloids is a critical step toward soil quality protection and ecological restoration. The objective of this study was to identify the potential sources of contamination of As, Cd, Cr, Cu, Hg, Mn, Pb, and Zn, and determine the contribution rates of each source, to rice and sugarcane agroecosystems of southwestern Guangxi, southern China. We collected a total of 300 soil samples at a former lead-zinc mine and at two reference sites, 6 and 60 km away from the mine, sampling both agroecosystems at each site. Overall, the positive matrix factorization (PMF) receptor model revealed that in rice paddies at the mine site, mining activities had the highest contribution (60.7% of all examined metals/metalloids), followed by irrigation (25.8%), and agrochemical application (13.5%). At the close reference site, agrochemical application contributed 42.8%, followed by irrigation (22.7%), natural sources (17.4%), and mining activities (17.2%). At the far reference site, agrochemical application was predominant (40.6%), followed by irrigation (32.5%), and natural sources (26.9%). In comparison, at the mine site and the close reference site in sugarcane ecosystems, agrochemical application was predominant (50.1% and 57.4%, respectively), followed by mining activities (49.9% and 42.6%). At the far reference site, agrochemical application contributed 51.2%, followed by natural sources (48.8%). Therefore, the PMF model indicated that the optimal solution was four or three sources per site for rice paddies, but only two sources per site for sugarcane, suggesting that sources of metal/metalloid contamination were more complicated in rice paddy than in sugarcane agroecosystems.

Multiple trace elements exposure of Grey-cheeked Fulvettas Alcippe morrisonia, a nuclear member in bird mixed-species flocks, and implications for bioindicator.

Birds are vulnerable to metal pollution, which can serve as indicators of environmental safety monitoring. In this study, we evaluated three non-essential (Pb, Cd, and As) and two essential (Cu and Zn) trace elements of living (only feathers) and deceased (feathers and tissues) Grey-cheeked Fulvetta (Alcippe morrisonia) at a highly polluted mine tailings and a reference site. Five metal concentrations in the feathers of living Grey-cheeked Fulvettas were higher at the mine site. Among these, the levels of Cd and Pb in most feathers exceeded the threshold, resulting in an ecotoxicological concern. The correlation analysis suggested that feathers from Grey-cheeked Fulvettas might be useful bioindicators for local metal contamination assessment. The toxicological effects of trace metals on Grey-cheeked Fulvetta might affect its leadership ability. Therefore, understanding the effects of metal pollution on Grey-cheeked Fulvetta would show important practical implications for the conservation of bird communities.

Niacin Improves Intestinal Health through Up-Regulation of AQPs Expression Induced by GPR109A.

(1) Background: Changes in the expression of aquaporins (AQPs) in the intestine are proved to be associated with the attenuation of diarrhea. Diarrhea is a severe problem for postweaning piglets. Therefore, this study aimed to investigate whether niacin could alleviate diarrhea in weaned piglets by regulating AQPs expression and the underlying mechanisms; (2) Methods: 72 weaned piglets (Duroc × (Landrace × Yorkshire), 21 d old, 6.60 ± 0.05 kg) were randomly allotted into 3 groups for a 14-day feeding trial. Each treatment group included 6 replicate pens and each pen included 4 barrows (n = 24/treatment). Piglets were fed a basal diet (CON), a basal diet supplemented with 20.4 mg niacin/kg diet (NA) or the basal diet administered an antagonist for the GPR109A receptor (MPN). Additionally, an established porcine intestinal epithelial cell line (IPEC-J2) was used to investigate the protective effects and underlying mechanism of niacin on AQPs expression after Escherichia coli K88 (ETEC K88) treatment; (3) Results: Piglets fed niacin-supplemented diet had significantly decreased diarrhea rate, and increased mRNA and protein level of ZO-1, AQP 1 and AQP 3 in the colon compared with those administered a fed diet supplemented with an antagonist (p < 0.05). In addition, ETEC K88 treatment significantly reduced the cell viability, cell migration, and mRNA and protein expression of AQP1, AQP3, AQP7, AQP9, AQP11, and GPR109A in IPEC-J2 cells (p < 0.05). However, supplementation with niacin significantly prevented the ETEC K88-induced decline in the cell viability, cell migration, and the expression level of AQPs mRNA and protein in IPEC-J2 cells (p < 0.05). Furthermore, siRNA GPR109A knockdown significantly abrogated the protective effect of niacin on ETEC K88-induced cell damage (p < 0.05); (4) Conclusions: Niacin supplementation increased AQPs and ZO-1 expression to reduce diarrhea and intestinal damage through GPR109A pathway in weaned piglets.

Supplemental Choline Modulates Growth Performance and Gut Inflammation by Altering the Gut Microbiota and Lipid Metabolism in Weaned Piglets.

BACKGROUND: Whether dietary choline and bile acids affect lipid use via gut microbiota is unclear. OBJECTIVES: This study aimed to investigate the effect of choline and bile acids on growth performance, lipid use, intestinal immunology, gut microbiota, and bacterial metabolites in weaned piglets. METHODS: A total of 128 weaned piglets [Duroc × (Landrace × Yorkshire), 21-d-old, 8.21 ± 0.20 kg body weight (BW)] were randomly allocated to 4 treatments (8 replicate pens per treatment, each pen containing 2 males and 2 females; n = 32 per treatment) for 28 d. Piglets were fed a control diet (CON) or the CON diet supplemented with 597 mg choline/kg (C), 500 mg bile acids/kg (BA) or both (C + BA) in a 2 × 2 factorial design. Growth performance, intestinal function, gut microbiota, and metabolites were determined. RESULTS: Compared with diets without choline, choline supplementation increased BW gain (6.13%), average daily gain (9.45%), gain per feed (8.18%), jejunal lipase activity (60.2%), and duodenal IL10 gene expression (51%), and decreased the mRNA abundance of duodenal TNFA (TNFα) (40.7%) and jejunal toll-like receptor 4 (32.9%) (P < 0.05); additionally, choline increased colonic butyrate (29.1%) and the abundance of Lactobacillus (42.3%), while decreasing the bile acid profile (55.8% to 57.6%) and the abundance of Parabacteroides (75.8%), Bacteroides (80.7%), and unidentified-Ruminococcaceae (32.5%) (P ≤ 0.05). Compared with diets without BA, BA supplementation decreased the mRNA abundance of colonic TNFA (37.4%), NF-κB p65 (42.4%), and myeloid differentiation factor 88 (42.5%) (P ≤ 0.01); BA also increased colonic butyrate (20.9%) and the abundance of Lactobacillus (39.7%) and Faecalibacterium (71.6%) and decreased that of Parabacteroides (67.7%) (P < 0.05). CONCLUSIONS: Choline supplementation improved growth performance and prevented gut inflammation in weaned piglets by altering gut microbiota and lipid metabolism. BA supplementation suppressed intestinal inflammation with no effect on growth performance, which was associated with changed gut microbiota and metabolites.

Real-time quantum edge enhanced imaging.

With the development of optical information processing technology, image edge enhancement technology has rapidly received extensive attention, especially in the field of quantum imaging. However, quantum edge enhanced imaging faces challenges in terms of time-consuming acquisition processes and the complexity of the devices used, which limits practical applications in real-time usage scenarios. Here we introduce and experimentally demonstrate a real-time (0.5 Hz) quantum edge enhanced imaging method that combines the spiral phase contrast technique with heralded single-photon imaging. The edge enhancement results show high quality and background free from raw data. Compared with direct imaging, our configuration can improve the signal-to-noise ratio significantly using the tight time correlations between photon pairs. The method also offers competitive advantages over ghost imaging, including higher brightness and a compact optical fiber delay rather than a free space delay. Additionally, we explore curved edge enhancement for specific feature recognition and the oriented shadow effect. Overall, this efficient and versatile platform paves an alternative path toward real-time quantum edge detection in applications including nondestructive bio-imaging, night vision and covert monitoring.

High-quality versatile photonic sources for multiple quantum optical experiments.

Entangled sources are important components for quantum information science and technology (QIST). The ability to generate high-quality entangled sources will determine the extent of progress in this field. Unlike previous schemes, a thin quasi-phase matching nonlinear crystal and a dense-wave-division-multiplexing device are used here to build high-quality versatile photonic sources with a simple configuration that can be used to perform Hong-Ou-Mandel interference, time-energy entanglement and multi-channel polarization entanglement experiments. The measurement results from various quantum optical experiments show the high quality of these photonic sources. These multi-functional photonic sources will be very useful in a variety of QIST applications.

Classical simulation of high-dimensional entanglement by non-separable angular-radial modes.

An analogous model system for high-dimensional quantum entanglement is proposed, based on the angular and radial degrees of freedom of the improved Laguerre Gaussian mode. Experimentally, we observed strong violations of the Bell-CGLMP inequality for maximally non-separable states of dimension 2 through 10. The results for violations in classical non-separable state are in very good agreement with quantum instance, which illustrates that our scheme can be a useful platform to simulate high-dimensional non-local entanglement. Additionally, we found that the Bell measurements provide sufficient criteria for identifying mode separability in a high-dimensional space. Similar to the two-dimensional spin-orbit non-separable state, the proposed high-dimensional angular-radial non-separable state may provide promising applications for classical and quantum information processing.

Nonlinear frequency conversion and manipulation of vector beams in a Sagnac loop.

Vector beams (VBs) are widely investigated for their special intensities and polarization distributions, which are useful in optical micromanipulation, optical microfabrication, optical communication, and single molecule imaging. To date, nonlinear frequency conversion (NFC) and manipulation of VBs remain challenging because of the polarization sensitivity of most nonlinear processes. Here we report an experimental realization of NFC and manipulation of VBs that can be used to expand the available frequency band. The main idea of our scheme is the introduction of a Sagnac loop to solve the polarization dependence problem of NFC in nonlinear crystals. Additionally, we find that a linearly polarized VB should be transformed into a hybrid-polarized VB in exponential form before performing NFC. The experimental results agree well with those of our theoretical model. The proposed method is also applicable to other wavebands and second-order nonlinear processes, and may be generalized to the quantum regime for single photons.

Quantum frequency conversion for multiplexed entangled states generated from micro-ring silicon chip.

Silicon-on-chip photonic circuits are among some very promising platforms for generating nonclassical photonic quantum state, because of its low loss, small footprint, and compatibility with complementary metal-oxide-semiconductor (CMOS) and telecommunications techniques. Dense wavelength division multiplexing (DWDM) is a leading technique for enhancing the transmission capacity of both classical and quantum communications. To bridge the frequency gap between silicon-chip and other quantum systems, such as quantum memories, a quantum interface is indispensable. Here, we demonstrate a quantum interface for multiplexed energy-time entanglement states, which are generated on a silicon micro-ring cavity that is based on frequency up-conversion. By switching the pump wavelength, energy-time entanglement from any channel can be selected at will after being up-converted. The high visibilities of two-photon interference over three channels after frequency up-conversion clearly prove that the entanglement is fully preserved during the quantum frequency conversion (QFC) process. Our work provides new perspectives regarding channel capacity enhancement in quantum communications and for quantum resources being transferred between two different quantum systems.

Revealing the Behavior of Photons in a Birefringent Interferometer.

The interferometer is one of the most important devices for revealing the nature of light and for precision optical metrology. Although many experiments were performed for probing photon behavior in various configurations, a complete study of photon behavior in a birefringent interferometer has not been performed, to our knowledge. By using an environmental turbulence immune Mach-Zehnder interferometer, we observe tunable photonic beatings by rotating a birefringent crystal versus the temperature of the crystal for both the single photon and two photons. Furthermore, the two-photon interference fringes beat 2 times faster than the single-photon interference fringes. This beating effect is used to determine the thermal dispersion coefficients of the two principal refractive axes with a single measurement: the two-photon interference shows superresolution and high sensitivity. Obvious differences between two-photon and single-photon interference are also revealed in unbalanced situations. In addition, the influence of the photon bandwidth on the beating behaviors that come from polarization-dependent decoherence is also investigated. Our findings will be important for better understanding the behavior of two-photon interference in a birefringent interferometer and for precision optical metrology with quantum enhancement.

Coherent frequency bridge between visible and telecommunications band for vortex light.

In quantum communications, vortex photons can encode higher-dimensional quantum states and build high-dimensional communication networks (HDCNs). The interfaces that connect different wavelengths are significant in HDCNs. We construct a coherent orbital angular momentum (OAM) frequency bridge via difference frequency conversion in a nonlinear bulk crystal for HDCNs. Using a single resonant cavity, maximum quantum conversion efficiencies from visible to infrared are 36%, 15%, and 7.8% for topological charges of 0,1, and 2, respectively. The average fidelity obtained using quantum state tomography for the down-converted infrared OAM-state of topological charge 1 is 96.51%. We also prove that the OAM is conserved in this process by measuring visible and infrared interference patterns. This coherent OAM frequency-down conversion bridge represents a basis for an interface between two high-dimensional quantum systems operating with different spectra.

Two-color hyper-entangled photon pairs generation in a cold 85Rb atomic ensemble.

Hyper-entangled photon pairs are very promising in the quantum information field for enhancing the channel capacity in communication and improving compatibility for networks. Here we report on the experimental generation of a hyper-entangled photon pair at a wavelength of 795 nm and 1475 nm via the spontaneous four-wave mixing process in a cold 85Rb atomic ensemble. The photons in each pair generated are entangled in both the time-frequency and polarization degrees of freedom. Such hyper-entangled photon pairs with special wavelength have potential applications in high-dimensional quantum communication and quantum physics.

Orbital Angular Momentum-Entanglement Frequency Transducer.

Entanglement is a vital resource for realizing many tasks such as teleportation, secure key distribution, metrology, and quantum computations. To effectively build entanglement between different quantum systems and share information between them, a frequency transducer to convert between quantum states of different wavelengths while retaining its quantum features is indispensable. Information encoded in the photon's orbital angular momentum (OAM) degrees of freedom is preferred in harnessing the information-carrying capacity of a single photon because of its unlimited dimensions. A quantum transducer, which operates at wavelengths from 1558.3 to 525 nm for OAM qubits, OAM-polarization hybrid-entangled states, and OAM-entangled states, is reported for the first time. Nonclassical properties and entanglements are demonstrated following the conversion process by performing quantum tomography, interference, and Bell inequality measurements. Our results demonstrate the capability to create an entanglement link between different quantum systems operating in a photon's OAM degrees of freedom, which will be of great importance in building a high-capacity OAM quantum network.

Is tranexamic acid clinically effective and safe to prevent blood loss in total knee arthroplasty? A meta-analysis of 34 randomized controlled trials.

BACKGROUND: Tranexamic acid (TXA) is well established as a versatile intraarticular and intravenous (IV) antifibrinolytic agent that has been successfully used to control bleeding after total knee arthroplasty (TKA). The present meta-analysis aimed at assessing the effectiveness and safety of TXA in reducing blood loss and transfusion in TKA. METHODS: We searched the PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, and Google Scholar databases from 1966 to December 2013. Only randomized controlled trials (RCTs) were included in the present study. Two independent reviewers identified the eligible studies, assessed their methodological quality, and extracted data. The data were using fixed-effects or random-effects models with standard mean differences and risk ratios for continuous and dichotomous variables, respectively. Subgroup analysis was performed according to the IV or intraarticular administration of TXA. RESULTS: Thirty-four RCTs encompassing 2,594 patients met the inclusion criteria for our meta-analysis. Our meta-analysis indicated that when compared with the control group, the IV or intraarticular use of TXA significantly reduced total blood loss, postoperative blood loss, Hb loss, and transfusion rate as well as blood units transfused per patient after primary TKA, but did not reduce intraoperative blood loss. No significant difference in deep vein thrombosis (DVT), pulmonary embolism, or other adverse events among the study groups. CONCLUSIONS: IV or intraarticular use of TXA for patients undergoing TKA is effective and safe for the reduction blood loss and blood transfusion requirements, yet does not increase the risk of postoperative DVT. LEVEL OF EVIDENCE: Level II.

[Comparison of structural characteristics and anticoagulation activity of enoxaparin sodium with different degree of 1,6-anhydro derivatives].

The fine structure of enoxaparin sodium samples with different degree of 1,6-anhydro derivatives were analyzed with polyacrylamide gel electrophoresis, high performance liquid chromatography, ultraviolet spectroscopy, infrared spectroscopy and nuclear magnetic resonance spectroscopy. A further study of anticoagulation activity of enoxaparins was performed, including those on their inhibition activities of coagulation factor Xa (FXa) and thrombin (FIIa). The results showed that the anti-FXa and -FIIa activities of enoxaparins with different degree of 1,6-anhydro derivatives (20.0%-39.7%) with similar structure characteristics, had decreasing tendency when the degree of 1,6-anhydro derivatives increased. Especially, the anti-FXa activity was sensitive to the change of the degree of 1,6-anhydro derivatives.

Stochastic processes shape the functional and phylogenetic structure of bird assemblages at the mine area in southwest China.

Understanding the mechanisms of community assembly is a key question in ecology. Metal pollution may result in significant changes in bird community structure and diversity, with implications for ecosystem processes and function. However, the relative importance of these processes in shaping the bird community at the polluted area is still not clear. Here, we explored bird species richness, functional, and phylogenetic diversity, and the assembly processes of community at the mine region of southwest China. Our results showed that the 3 dimensions of diversity at the mine area were lower than that at the reference sites. In the community assembly, the result was 0 < NRI/ NFRI < 1.96, which indicated deterministic processes (environmental filtering) might drive community clustering. The results of the neutral community model, and normalized stochasticity ratio, showed the dominant role of stochastic processes in shaping the bird community assembly. We further quantified the community-level habitat niche breadth (Bcom), and we found that there was no difference in Bcom-value between the mine area and reference sites. This indicates that the bird communities at the mine area and 3 reference sites were not subjected to extreme environmental selection (same or different resource allocation) to form a highly specialized niche. These findings provide insights into the distribution patterns and dominant ecological processes of bird communities under metal exposure, and extend the knowledge in community assembly mechanisms of bird communities living in the mine area.

DN-DETR: Accelerate DETR Training by Introducing Query DeNoising.

We present in this paper a novel denoising training method to speed up DETR (DEtection TRansformer) training and offer a deepened understanding of the slow convergence issue of DETR-like methods. We show that the slow convergence results from the instability of bipartite graph matching which causes inconsistent optimization goals in early training stages. To address this issue, except for the Hungarian loss, our method additionally feeds GT bounding boxes with noises into the Transformer decoder and trains the model to reconstruct the original boxes, which effectively reduces the bipartite graph matching difficulty and leads to faster convergence. Our method is universal and can be easily plugged into any DETR-like method by adding dozens of lines of code to achieve a remarkable improvement. As a result, our DN-DETR results in a remarkable improvement ( +1.9AP) under the same setting and achieves 46.0 AP and 49.5 AP trained for 12 and 50 epochs with the ResNet-50 backbone. Compared with the baseline under the same setting, DN-DETR achieves comparable performance with 50% training epochs. We also demonstrate the effectiveness of denoising training in CNN-based detectors (Faster R-CNN), segmentation models (Mask2Former, Mask DINO), and more DETR-based models (DETR, Anchor DETR, Deformable DETR).