Detalhe da pesquisa
1.
Organ aging signatures in the plasma proteome track health and disease.
Nature
; 624(7990): 164-172, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38057571
2.
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Nature
; 590(7844): 122-128, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33473210
3.
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome.
Proc Natl Acad Sci U S A
; 119(7)2022 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35165147
4.
Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics.
Am J Hum Genet
; 108(12): 2336-2353, 2021 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34767756
5.
A TrkB and TrkC partial agonist restores deficits in synaptic function and promotes activity-dependent synaptic and microglial transcriptomic changes in a late-stage Alzheimer's mouse model.
Alzheimers Dement
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38779814
6.
Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.
J Neuroinflammation
; 20(1): 48, 2023 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36829230
7.
Small molecule modulation of TrkB and TrkC neurotrophin receptors prevents cholinergic neuron atrophy in an Alzheimer's disease mouse model at an advanced pathological stage.
Neurobiol Dis
; 162: 105563, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34838668
8.
Post-Stroke Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Attenuates Chronic Changes in Brain Metabolism, Increases Neurotransmitter Levels, and Improves Recovery.
J Pharmacol Exp Ther
; 380(2): 126-141, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34893553
9.
Oral Administration of the p75 Neurotrophin Receptor Modulator, LM11A-31, Improves Erectile Function in a Mouse Model of Cavernous Nerve Injury.
J Sex Med
; 18(1): 17-28, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33243690
10.
Soluble TREM2 is elevated in Parkinson's disease subgroups with increased CSF tau.
Brain
; 143(3): 932-943, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32065223
11.
Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury.
Cereb Cortex
; 30(9): 5180-5189, 2020 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32488246
12.
Modulation of p75NTR on Mesenchymal Stem Cells Increases Their Vascular Protection in Retinal Ischemia-Reperfusion Mouse Model.
Int J Mol Sci
; 22(2)2021 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33467640
13.
TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31.
Hum Mol Genet
; 27(16): 2893-2912, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29860333
14.
Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.
Diabetologia
; 62(8): 1488-1500, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31073629
15.
Receptor dependence of BDNF actions in superficial dorsal horn: relation to central sensitization and actions of macrophage colony stimulating factor 1.
J Neurophysiol
; 121(6): 2308-2322, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30995156
16.
Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons.
Neurobiol Dis
; 113: 45-58, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29408225
17.
Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.
Neurobiol Dis
; 112: 63-78, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29331263
18.
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.
Hum Mol Genet
; 25(22): 4920-4938, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28171570
19.
Unsolicited Patient Complaints Identify Physicians with Evidence of Neurocognitive Disorders.
Am J Geriatr Psychiatry
; 26(9): 927-936, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30146001
20.
The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.
J Neurosci
; 36(39): 10116-27, 2016 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27683907