RESUMO
Oral anticoagulants were administered to a young woman suffering from P.N.H. after the development of portal vein thrombosis. She interrupted the treatment and developed multiple splanchnic thromboses followed by acute renal failure, from which she recovered four weeks later. Although the pathogenetic mechanism could include renal vascular microthrombosis, the possibility of renal ischemic damage due to massive blood pooling within the splanchnic district is discussed.
Assuntos
Injúria Renal Aguda/etiologia , Hemoglobinúria Paroxística/complicações , Veias Mesentéricas , Veia Porta , Veia Esplênica , Trombose/etiologia , Adulto , Feminino , Hemoglobinúria Paroxística/diagnóstico , Humanos , Trombose/diagnóstico , UltrassonografiaRESUMO
Some uncertainty about deferoxamine ototoxicity is to be found in the literature. Therefore, 100 patients affected by beta-thalassemia were checked audiologically. Twelve of them showed a sensorineural hearing impairment which in most cases was confined to 4 and 8 kHz. If these results are compared with a sample of "normal" population, no significant difference can be observed, therefore excluding that deferoxamine, at least at present dosages, may be considered as a certain cause of cochlear impairment.