Detalhe da pesquisa
1.
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Proc Natl Acad Sci U S A
; 120(11): e2219523120, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893269
2.
Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
Mol Ther
; 31(6): 1661-1674, 2023 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37177784
3.
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Nucleic Acids Res
; 47(3): 1070-1081, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30535404
4.
Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease.
Mol Ther
; 31(11): 3355-3356, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37751745
5.
Visualization of self-delivering hydrophobically modified siRNA cellular internalization.
Nucleic Acids Res
; 45(1): 15-25, 2017 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27899655
6.
Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo.
Bioconjug Chem
; 29(7): 2478-2488, 2018 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29898368
7.
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.
Mol Ther
; 24(10): 1836-1847, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27506293
8.
Long-range effects of familial hypertrophic cardiomyopathy mutations E180G and D175N on the properties of tropomyosin.
Biochemistry
; 51(32): 6413-20, 2012 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22794249
9.
Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo.
J Control Release
; 349: 831-843, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35917865
10.
Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains.
Brain Commun
; 4(6): fcac248, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36458209
11.
Tropomyosin is in a reduced state in rabbit psoas muscle.
J Muscle Res Cell Motil
; 32(1): 19-21, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21590498
12.
Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.
Mol Ther Nucleic Acids
; 21: 991-1005, 2020 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32818923
13.
Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference.
Mol Ther Nucleic Acids
; 21: 384-393, 2020 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32650236
14.
CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets.
Diabetes
; 67(5): 872-884, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432124
15.
Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.
Cell Rep
; 24(10): 2553-2560.e5, 2018 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30184490
16.
Tropomyosin is in a reduced state in rat cardiac muscle.
J Muscle Res Cell Motil
; 32(2): 63-4, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21789684