RESUMO
OBJECTIVES: To test lumiracoxib used preemptively against a placebo,and to analyse the analgesic administration (dipirona and tramadol) in the 24 first postoperative hours. METHODS: Sixty patients undergone to a breast aumentation, under epidural anesthesia, were selected and put randomly in two groups - GI and GII. Sixty minutes before the surgery, it was administered orally, one pill of lumiracoxib 400mg to the 30 GI patients and one pill of placebo to the 30 GII patients. The postoperative pain was evaluated through the visual analogic scale, ranged from 0 (painless) to 10 (most intensive pain), being applied to the patient whenever having pain. For the same scores or under 4, it was administered intravenously 15mg/kg of dipirona up to a maximum of 1g. For scores of 5, 6 or 7, the patient had intravenously 50mg of tramadol.Scores 8 or more were treated intravenously with 0,5 mg/kg of meperidine. RESULTS: The scores in GI were significantly lower than the ones obtained in GII within the first 24 hours, with the need of 20% less dipirona and 56% of tramadol in this period of time. In the same way, it was observed that analgesic solicitation for the first time had a delay of 191 minutes in GI in comparison to GII. CONCLUSION: The use of lumiracoxib preemptively, was effective in the treatment of postoperative pain, reducing considerably the consume of analgesics, and enlarging the time for the first medication.
Assuntos
Analgesia , Diclofenaco/análogos & derivados , Dor Pós-Operatória/prevenção & controle , Adulto , Analgésicos Opioides/administração & dosagem , Inibidores da Enzima Conversora de Angiotensina/administração & dosagem , Diclofenaco/uso terapêutico , Dipirona/administração & dosagem , Feminino , Humanos , Fatores de Tempo , Tramadol/administração & dosagemRESUMO
OBJETIVO: Testar o lumiracoxibe, utilizado preemptivamente contra um placebo, e analisar o consumo de analgésicos (dipirona e tramadol) nas primeiras 24h do pós-operatório. MÉTODOS: Sessenta pacientes submetidas à mamoplastia de aumento, sob anestesia peridural, foram selecionadas e divididas de forma randomizada em dois grupos - GI e GII. Sessenta minutos antes da operação, por via oral, as 30 pacientes do GI receberam um comprimido de lumiracoxibe 400mg, e as 30 do GII um comprimido de placebo. A dor pós-operatória foi avaliada através da escala analógica visual, graduada de 0 (sem dor) a 10 (dor de maior intensidade), sendo aplicada sempre que houvesse referência de dor. Para escores obtidos iguais ou menores que 4, a paciente recebia 15mg/kg de dipirona, até máximo de um grama, via venosa. Para escores de 5, 6 ou 7, recebia 50mg de tramadol por via venosa. Escores de 8 ou mais eram tratados com 0,5mg/kg de meperidina endovenosa. RESULTADOS: Os escores obtidos no GI foram significativamente menores que os do GII dentro das primeiras 24 horas, resultando em consumo 20 por cento menor de dipirona e 56 por cento menor de tramadol. Da mesma forma, observou-se que o tempo para solicitação de analgésicos pela primeira vez no pós-operatório foi de 191 minutos maior no GI. CONCLUSÃO: O emprego do lumiracoxibe preemptivamente mostrou-se efetivo no combate à dor pós-operatória, reduzindo consideravelmente o consumo global de analgésicos nesse período e aumentando o tempo de solicitação de analgésico pela primeira vez.
OBJECTIVES: To test lumiracoxib used preemptively against a placebo,and to analyse the analgesic administration (dipirona and tramadol) in the 24 first postoperative hours. METHODS: Sixty patients undergone to a breast aumentation, under epidural anesthesia, were selected and put randomly in two groups - GI and GII. Sixty minutes before the surgery, it was administered orally, one pill of lumiracoxib 400mg to the 30 GI patients and one pill of placebo to the 30 GII patients. The postoperative pain was evaluated through the visual analogic scale, ranged from 0 (painless) to 10 (most intensive pain), being applied to the patient whenever having pain. For the same scores or under 4, it was administered intravenously 15mg/kg of dipirona up to a maximum of 1g. For scores of 5, 6 or 7, the patient had intravenously 50mg of tramadol.Scores 8 or more were treated intravenously with 0,5 mg/kg of meperidine. RESULTS: The scores in GI were significantly lower than the ones obtained in GII within the first 24 hours, with the need of 20 percent less dipirona and 56 percent of tramadol in this period of time. In the same way, it was observed that analgesic solicitation for the first time had a delay of 191 minutes in GI in comparison to GII. CONCLUSION: The use of lumiracoxib preemptively, was effective in the treatment of postoperative pain, reducing considerably the consume of analgesics, and enlarging the time for the first medication.