1.
Bioorg Med Chem Lett
; 8(21): 2955-60, 1998 Nov 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9873654
RESUMO
Synthesis of a variety of 5,5-trans fused lactones, related to compounds found in extracts of Lantana camara, has provided a series of novel acylating inhibitors of human thrombin, trypsin, chymotrypsin and human leucocyte elastase. The most effective thrombin inhibitor is 7 with an IC50 of 130 nM and a Kobs/[1] of 4,000 M-1 s-1.