RESUMO
In children, the most typical soft tissue tumor is a rhabdomyosarcoma (RMS). A primary intratesticular rhabdomyosarcoma is quite uncommon. An eleven-year-old had a painless left testicular tumor for two months. The patient's left scrotum was found to have a firm, non-tender lump. A massive hypoechoic intratesticular mass measuring 8.0 × 7.5 × 6.0 cm was found in the left scrotum by scrotal and abdominal ultrasonography. The patient had an inguinal orchiectomy. Histopathological examination disclosed botryoid rhabdomyosarcoma. Primary intratesticular rhabdomyosarcomas are rare. Radical orchiectomy and chemotherapy are recommended. It may increase overall and disease-free survival.
RESUMO
PURPOSE: To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation. METHODS: This was a cross-sectional study of primary enucleated group D/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [Community Eye Health. 2018;31(101):17-3]. RESULTS: This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25-36 months. High-risk features (HRFs) were found in 100/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age >2 years associated with tumor differentiation (p < 0.05). CONCLUSION: The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged >2 years old.