RESUMO
The clinical trials on 31 patients with arteriosclerosis and I-II stage discirculatory encephalopathy to assess an ability of Ascovertin to limit hemorheology abnormalities were carried out. In patients with discirculatory encephalopathy was a distinct increase in blood viscosity which was induced by disturbances of cell rheological factors: increase in aggregation of erythrocytes and decrease in their deformability were observed in comparison with indices in the group of healthy volunteers. No difference in plasma viscosity and fibrinogen was found. The treatment with Ascovertin in patients with discirculatory encephalopathy improved their attention, memory, mental performance, normalized sleep, releaved headache, decreased fatiquebility, led to the decrease in blood viscosity values, the reduction of pathological erythrocyte hyper aggregation and the improvement of erythrocyte deformability. We partly connect this clinical effect and hemorheology activity of Ascovertin with its antioxidant property--there was found impressive lipid peroxidation suppression. No significant changes in hemorheological and lipid peroxidation indices were observed in patients without Ascovertin.
Assuntos
Antioxidantes/uso terapêutico , Hemorreologia , Arteriosclerose Intracraniana/tratamento farmacológico , Viscosidade Sanguínea , Artérias Cerebrais/patologia , Agregação Eritrocítica/efeitos dos fármacos , Agregação Eritrocítica/fisiologia , Deformação Eritrocítica/efeitos dos fármacos , Fibrinogênio/metabolismo , Humanos , Arteriosclerose Intracraniana/sangue , Valores de Referência , EscleroseRESUMO
Experiments on rats showed that n-tyrosol limited the increase in blood viscosity during thermal exposure at a shear rate of 5-300 sec(-1) and inhibited ADP-induced platelet aggregation. The effects of n-tyrosol are comparable to that of pentoxyphylline.
Assuntos
Viscosidade Sanguínea/efeitos dos fármacos , Álcool Feniletílico/análogos & derivados , Inibidores da Agregação Plaquetária/farmacologia , Agregação Plaquetária/efeitos dos fármacos , Animais , Hemorreologia , Técnicas In Vitro , Masculino , Álcool Feniletílico/farmacologia , Ratos , Ratos WistarRESUMO
Considerable hemorheological changes and depression of EEG parameters were revealed in rats with cerebral ischemia. Course peroral treatment with scarlet lightning extract in a daily dose of 150 mg/kg for 5 days reduced the severity of hemorheological disorders. It manifested in a decrease in whole blood viscosity, plasma viscosity, erythrocyte aggregation, and fibrinogen concentration and increase in deformability. The extract of lightning extract improved EEG activity in rats with cerebral ischemia.
Assuntos
Isquemia Encefálica/tratamento farmacológico , Encéfalo/irrigação sanguínea , Lychnis/química , Fármacos Neuroprotetores/uso terapêutico , Extratos Vegetais/uso terapêutico , Animais , Viscosidade Sanguínea/efeitos dos fármacos , Encéfalo/efeitos dos fármacos , Encéfalo/fisiologia , Isquemia Encefálica/sangue , Eletroencefalografia/efeitos dos fármacos , Hemorreologia , Fármacos Neuroprotetores/química , Fármacos Neuroprotetores/farmacologia , Extratos Vegetais/farmacologia , Ratos , SileneRESUMO
A course of ascovertin therapy reduced manifestations of perifocal inflammation and atresia of growing follicles, corrected vascular disorders and changes in the tissue volume ratios outside the necrotic zone after monopolar coagulation of the ovaries in rats. The drug prevented the increase in blood viscosity, erythrocyte aggregation, and LPO activation in the early postoperation period.