Detalhe da pesquisa
1.
Scalable Asymmetric Syntheses of Foslevodopa and Foscarbidopa Drug Substances for the Treatment of Parkinson's Disease.
J Org Chem
; 87(4): 1986-1995, 2022 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34280307
2.
Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.
Bioorg Med Chem
; 63: 116743, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35436748
3.
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorg Med Chem Lett
; 20(22): 6812-5, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855211
4.
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
J Med Chem
; 61(9): 4052-4066, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653491
5.
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
J Med Chem
; 49(23): 6726-31, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154503
6.
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
J Med Chem
; 49(17): 5093-109, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913699
7.
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
J Med Chem
; 49(25): 7450-65, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17149874
8.
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
J Med Chem
; 59(7): 3373-91, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27015369
9.
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels.
Pain
; 117(1-2): 88-96, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061325
10.
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.
J Med Chem
; 45(17): 3639-48, 2002 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12166937
11.
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
J Med Chem
; 47(9): 2348-55, 2004 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084133
12.
[3H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D4 receptor.
Eur J Pharmacol
; 497(2): 147-54, 2004 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15306199
13.
Total Synthesis of (-)-Tetrahydropalmatine via Chiral Formamidine Carbanions: Unexpected Behavior with Certain Ortho-Substituted Electrophiles.
J Org Chem
; 61(2): 573-580, 1996 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-11666977
14.
Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
J Med Chem
; 57(5): 2047-57, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24400777
15.
A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
Neuropharmacology
; 59(3): 201-7, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20566409
16.
Voltage-gated sodium channel blockers for the treatment of chronic pain.
Curr Top Med Chem
; 9(4): 362-76, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19442207
17.
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Bioorg Med Chem
; 15(4): 1586-605, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17197188
18.
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Proc Natl Acad Sci U S A
; 104(20): 8520-5, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17483457
19.
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.
Bioorg Med Chem
; 13(15): 4667-78, 2005 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15896964
20.
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.
Bioorg Med Chem
; 13(11): 3705-20, 2005 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15863000