Detalhe da pesquisa
1.
Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies.
Handb Exp Pharmacol
; 257: 147-162, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31595415
2.
Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain.
J Pharmacol Exp Ther
; 361(1): 190-197, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28138041
3.
Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists.
Bioorg Med Chem Lett
; 25(19): 4158-63, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26299349
4.
Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor ß ligand.
Proc Natl Acad Sci U S A
; 109(5): 1708-12, 2012 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22307635
5.
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Int J Neuropsychopharmacol
; 18(2)2014 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25637376
6.
Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
Bioorg Med Chem Lett
; 23(5): 1249-52, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374867
7.
Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.
Radiat Res
; 199(5): 468-489, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37014943
8.
Muscarinic mechanisms in psychotic disorders.
Handb Exp Pharmacol
; (213): 233-65, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23027418
9.
Microglial knockdown does not affect acute withdrawal but delays analgesic tolerance from oxycodone in male and female C57BL/6J mice.
Adv Drug Alcohol Res
; 2: 10848, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-38390615
10.
Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species.
J Alzheimers Dis Rep
; 6(1): 1-15, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35243208
11.
Bassoon contributes to tau-seed propagation and neurotoxicity.
Nat Neurosci
; 25(12): 1597-1607, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36344699
12.
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
J Med Chem
; 64(12): 8076-8100, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081466
13.
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
Int J Neuropsychopharmacol
; 13(8): 1021-33, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20569520
14.
In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268).
J Pharmacol Exp Ther
; 331(3): 1126-36, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19755662
15.
Autonomic activation associated with ethanol self-administration in adult female P rats.
Pharmacol Biochem Behav
; 91(2): 223-32, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18713644
16.
Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats.
Pain
; 159(7): 1403-1412, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-29578947
17.
Synthesis and Pharmacological Characterization of C4ß-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist.
J Med Chem
; 61(6): 2303-2328, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29350927
18.
Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats.
Neuropharmacology
; 53(8): 930-41, 2007 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17959202
19.
In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.
Psychopharmacology (Berl)
; 193(1): 121-36, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17384937
20.
Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice.
Neuropsychopharmacology
; 31(6): 1135-45, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16205780