Detalhe da pesquisa
1.
ASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice.
Mol Ther
; 32(5): 1359-1372, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38429929
2.
Antisense Oligonucleotide Silencing Reverses Abnormal Neurochemistry in Spinocerebellar Ataxia 3 Mice.
Ann Neurol
; 94(4): 658-671, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243335
3.
Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.
J Neurosci
; 42(8): 1604-1617, 2022 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35042771
4.
Standards of Fluid Biomarker Collection and Pre-analytical Processes in Humans and Mice: Recommendations by the Ataxia Global Initiative Working Group on Biomarkers.
Cerebellum
; 2023 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243885
5.
Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage.
J Biol Chem
; 297(1): 100813, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34023384
6.
Antisense Oligonucleotide Therapy Targeted Against ATXN3 Improves Potassium Channel-Mediated Purkinje Neuron Dysfunction in Spinocerebellar Ataxia Type 3.
Cerebellum
; 20(1): 41-53, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32789747
7.
Pathogenesis of SCA3 and implications for other polyglutamine diseases.
Neurobiol Dis
; 134: 104635, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31669734
8.
In Vivo Molecular Signatures of Cerebellar Pathology in Spinocerebellar Ataxia Type 3.
Mov Disord
; 35(10): 1774-1786, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32621646
9.
Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann-Pick diseases.
BMC Med
; 17(1): 200, 2019 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31711490
10.
Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.
Ann Neurol
; 84(1): 64-77, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29908063
11.
Human-specific microRNA regulation of FOXO1: implications for microRNA recognition element evolution.
Hum Mol Genet
; 23(10): 2593-603, 2014 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24368418
12.
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1.
Neuron
; 112(3): 362-383.e15, 2024 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38016472
13.
Diverse regional mechanisms drive spinocerebellar ataxia type 1 phenotypes.
Neuron
; 111(4): 447-449, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36796325
14.
Myelinating Glia: Potential Therapeutic Targets in Polyglutamine Spinocerebellar Ataxias.
Cells
; 12(4)2023 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36831268
15.
Disease-associated oligodendrocyte signatures are spatiotemporally dysregulated in spinocerebellar ataxia type 3.
Front Neurosci
; 17: 1118429, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36875652
16.
Blood neurofilament light chain levels are associated with disease progression in a transgenic SCA3 mouse model.
bioRxiv
; 2023 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36909535
17.
Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias.
bioRxiv
; 2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37214832
18.
Blood levels of neurofilament light are associated with disease progression in a mouse model of spinocerebellar ataxia type 3.
Dis Model Mech
; 16(9)2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37664882
19.
Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla.
Front Neurosci
; 17: 1278828, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37954878
20.
Pathogenetic Mechanisms Underlying Spinocerebellar Ataxia Type 3 Are Altered in Primary Oligodendrocyte Culture.
Cells
; 11(16)2022 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36010688