Detalhe da pesquisa
1.
Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available heat shock protein 90 inhibitor in a human tumor xenograft mouse model.
J Pharmacol Exp Ther
; 338(3): 964-73, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21680888
2.
Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone.
Bioorg Med Chem Lett
; 21(12): 3557-62, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21612924
3.
Solution-phase parallel synthesis of Hsp90 inhibitors.
J Comb Chem
; 11(5): 860-74, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19583220
4.
Synergy between celecoxib and radiotherapy results from inhibition of cyclooxygenase-2-derived prostaglandin E2, a survival factor for tumor and associated vasculature.
Cancer Res
; 64(1): 279-85, 2004 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14729635
5.
Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy.
J Med Chem
; 48(21): 6713-30, 2005 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16220987
6.
Targeting small cell lung cancer harboring PIK3CA mutation with a selective oral PI3K inhibitor PF-4989216.
Clin Cancer Res
; 20(3): 631-43, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24240111
7.
miR-122 regulates tumorigenesis in hepatocellular carcinoma by targeting AKT3.
PLoS One
; 8(11): e79655, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24244539
8.
miR-221 promotes tumorigenesis in human triple negative breast cancer cells.
PLoS One
; 8(4): e62170, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23637992
9.
Retraction notice to "A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells".
Cancer Lett
; 422: 132, 2018 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29579439
10.
Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90.
Clin Cancer Res
; 17(16): 5432-42, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21715568
11.
RETRACTED: A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells.
Cancer Lett
; 300(1): 30-9, 2011 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20926183
12.
PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity.
Mol Cancer Ther
; 10(11): 2189-99, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21750219
13.
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
J Med Chem
; 54(9): 3368-85, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21438541
14.
PF-03732010: a fully human monoclonal antibody against P-cadherin with antitumor and antimetastatic activity.
Clin Cancer Res
; 16(21): 5177-88, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20829331
15.
Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
J Med Chem
; 53(18): 6653-80, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20726512
16.
Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease.
Bioorg Med Chem
; 11(22): 4769-77, 2003 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-14556792