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Nucleic Acids Res ; 38(12): 3857-68, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20194113

RESUMO

In their natural environments, microorganisms form complex systems of interactions. Understating the structure and organization of bacterial communities is likely to have broad medical and ecological consequences, yet a comprehensive description of the network of environmental interactions is currently lacking. Here, we mine co-occurrences in the scientific literature to construct such a network and demonstrate an expected pattern of association between the species' lifestyle and the recorded number of co-occurring partners. We further focus on the well-annotated gut community and show that most co-occurrence interactions of typical gut bacteria occur within this community. The network is then clustered into species-groups that significantly correspond with natural occurring communities. The relationships between resource competition, metabolic yield and growth rate within the clusters correspond with the r/K selection theory. Overall, these results support the constructed clusters as a first approximation of a bacterial ecosystem model. This comprehensive collection of predicted communities forms a new data resource for further systematic characterization of the ecological design principals shaping communities. Here, we demonstrate its utility for predicting cooperation and inhibition within communities.


Assuntos
Fenômenos Fisiológicos Bacterianos , Ecossistema , Microbiologia Ambiental , Interações Microbianas , Bactérias/crescimento & desenvolvimento , Bactérias/metabolismo , Mineração de Dados , PubMed
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