Kidney graft functionality 1 year after kidney transplantation.

OBJECTIVE: To determine the evolution, associated factors and the outcomes of transplanted people one year after the evolution of a cohort in Mexico. METHOD: Kidney transplant cohort from 2013 to 2017 in Mexico. 1118 patients were analyzed. Five outcomes were studied: overall survival, kidney graft, patient survival, delayed function, and acute dysfunction. Kaplan-Meier was used for kidney graft survival. For risk, bivariate and multivariate analyzes were performed with a significant value of p < 0.05. RESULTS: Of the 1118 kidney transplant patients, 57 (5.09%) had kidney graft loss, 52 (4.65%) died during the one-year follow-up; survival of the patient of 95.35% and of the graft 90.25%. CONCLUSIONS: The risk factors for the outcomes were transplantation from a deceased donor, recipient over 50 years of age and use of polyclonal agents. Infections and age are related to the death of the patient.

OBJETIVO: Determinar la funcionalidad del injerto renal a 1 año en una cohorte retrospectiva en México. MÉTODO: Cohorte de trasplante renal de 2013 a 2017 en México. Se analizaron 1118 pacientes. Se estudiaron cinco desenlaces: supervivencia global, supervivencia del injerto renal, supervivencia del paciente, función retardada y disfunción aguda. Para la supervivencia del injerto renal se usó Kaplan-Meier. Para el riesgo se realizó análisis bivariado y multivariado con valor significativo p < 0.05. RESULTADOS: De los 1118 pacientes con trasplante renal, 57 (5.09%) tuvieron pérdida del injerto, 52 (4.65 %) fallecieron durante el año de seguimiento; la supervivencia del paciente fue del 95.35% y la supervivencia del injerto fue del 90.25%. CONCLUSIONES: Los factores de riesgo para los desenlaces fueron trasplante de donante fallecido, receptor mayor de 50 años y uso de agentes policlonales. Las infecciones y la edad están relacionadas con la muerte del paciente.

Evaluation of Renal Function at 24, 48, and 72 Hours and 3 Months After Transplant: Comparison of 3 Anesthetic Techniques.

BACKGROUND: General anesthesia is the conventional management of renal transplant, and its evolution has revolved around the development of new drugs; however, a group of patients meet conditions for neuraxial anesthesia, because of their comorbidities, who are at greater risk of complications with general anesthesia and are not favorable to grafting. METHODS: We conducted a controlled clinical trial of 109 renal transplant recipients where renal function was evaluated at 24, 48, and 72 hours and 3 months after transplant, and we compared regional, general anesthesia with inhaled anesthetic and total intravenous anesthesia. It was performed for 1 year, and serum creatinine, urea nitrogen, and electrolytes were evaluated. During the intraoperative period central venous pressure, mean arterial pressure, vasopressors, fluid therapy, diuretics, surgical time, anesthesia, hot and cold ischemia, immunosuppressants, and antihypertensives were evaluated. They were analyzed with χ2 independence and 1-way and 2-way repeated measures. RESULTS: The type of anesthesia was associated with hemodynamic stability (P = .018), the use of vasopressor (P = .005), and fluid therapy (P = .011). A value of P = .005 was found for central venous pressure at discharge from the operating room, and preincisional mean arterial pressure (P = .015) was among the types of anesthesia. Creatinine, blood urea nitrogen, sodium, and potassium were statistically significant over time (P < .001) but showed no difference between types of anesthesia. CONCLUSION: There is no difference between anesthetic techniques and clinical results over time. The personalized anesthetic technique will improve the neuroendocrine response and surgical stress, decrease the need for vasopressors and analgesics, and reduce complications.

[Modification of health-related quality of life in kidney transplant recipients]. / Modificación de la calidad de vida relacionada con la salud en receptores de trasplante renal.

INTRODUCTION: The assessment of health-related quality of life is essential to renal replacement therapies. We conducted a study to evaluate the change in quality of life at 6 and 12 months after renal transplantation and compared with healthy population and general population. METHODS: A prospective study in 278 renal transplant recipients using the SF-36 survey at 0, 6 and 12 months after transplantation. The results were compared with those obtained in healthy population (kidney donors) and general population. Student t test was employed for comparisons of means. A value of p<0.05 was considered statistically significant. RESULTS: The quality of life before transplantation was lower than that observed in healthy population and the general population (p<0.001). At 6 months of transplantation significant improvement over the baseline measurement (p<0.001) in the 8 domains and the two composite scales was obtained, but at 12 months, an additional benefit was not observed. The quality of life of recipients at 12 months of transplant was lower only in the concept of general health (p=0.035) compared with healthy population. However, it was higher than general population in physical and mental composite scales (p=0.013 and p=0.001 respectively). CONCLUSIONS: The health related quality of life improved significantly at 6 and 12 months after renal transplantation, achieving equated healthy population and general population.

Introducción: la evaluación de la calidad de vida relacionada con la salud es fundamental en las terapias de reemplazo renal. Realizamos un estudio para evaluar la modificación en la calidad de vida a los 6 y 12 meses del trasplante renal y compararla con población sana y población general. Métodos: se realizó un estudio prospectivo en 278 receptores renales aplicando la encuesta SF-36 a los 0, 6 y 12 meses del trasplante. Los resultados fueron comparados con los obtenidos en población sana (donantes renales) y población general. Se empleó prueba t de student para realizar las comparaciones de medias. Una p < 0.05 fue considerada estadísticamente significativa.Resultados: la calidad de vida previa al trasplante fue inferior a la observada en población sana y población general (p < 0.001). A los 6 meses de trasplante se obtuvo mejoría significativa con respecto a la medición basal (p < 0.001) en los 8 dominios y las dos escalas compuestas, pero a los 12 meses no se observó un beneficio adicional. La calidad de vida de los receptores a los 12 meses de trasplante fue inferior solo en el concepto de salud general (p = 0.035) al compararse con la población sana. No obstante, fue superior a la población general en las escalas compuestas física y mental (p = 0.013 y p = 0.001 respectivamente).Conclusiones: la calidad de vida relacionada con la salud mejora significativamente a los 6 y 12 meses del trasplante renal, logrando equipararse con población sana y población general.