RESUMO
Gold(III) complexes are widely studied as antitumor agents and show good results. The interaction with biologically active thiols (thiomalate, cysteine, glutathione (GSH) and human serum albumin) of a number of gold(III) complexes with N-containing polydentate ligands in aqueous solution with pH 7.4 and 0.2 M NaCl was studied. Complexes with 1,10-phenanthroline and 2,2'-bipyridyl, Au(phen)(OH)2+ and Au(bipy)(OH)2+, react fast with an excess of any of these thiols and in less than a few seconds transform into gold(I) bis-thiolate complexes. For complexes with deprotonated ethylenediamine and diethylenetriamine, Au(en)(en-H)2+ and Au(dien-H)(Cl,OH)+, at a significant excess of GSH, a relatively long-lived gold(III) complex AuIII(GSH)iLj is formed. At t = 37 °C, it transforms into the gold(I) bis-thiolate complex Au(GSH)2 by 90% in 4 h. However, for other thiols, the rate of decomposition of similar complexes is about 10 times higher. Some other complexes were also considered. In all cases, a fairly fast reduction of gold(III) to gold(I) occurs with the formation of the gold(I) bis-thiolates.