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1.
J Adolesc ; 96(4): 865-873, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38311967

RESUMO

INTRODUCTION: The COVID-19 pandemic likely affected adolescent sexual behaviors and alcohol use, although how is not well understood. METHOD: Youth were sampled from the national, online longitudinal Growing up with Media study. They responded via text messaging to open-ended questions about how the COVID-19 pandemic may have impacted the sexual behavior and alcohol use of adolescents. Conventional content analysis summarized open-ended responses. RESULTS: 416 responses were analyzed from 335 participants (aged 15-30, US residents), 81 of whom provided data for both topics. Participants suggested that the pandemic affected some youths' sexual health precautions (increased and varying) and attitudes about sex (positive and negative). They discussed how adolescents met partners during the pandemic, including increased use of online platforms. Participants also suggested researchers investigate sexual risk in the realm of COVID-19 transmission and the practice of "safe sex." Many participants believed adolescents were drinking alcohol more as a result of the pandemic, both alone and with friends; however, others perceived adolescents were drinking less. Participants proposed researchers investigate adolescent drinking habits during the pandemic, as well as how this compares to before the pandemic and the type and quantity of alcohol consumed. CONCLUSIONS: Young people believe adolescent sexual relationships and drinking behaviors changed due to the pandemic, though how varied. Future research could examine the contexts and individual differences that shape these varying behaviors. Overall, this study highlights the importance of directly asking youth about their pandemic experiences and the diversity of views on how the pandemic has influenced adolescent behavior.


Assuntos
Comportamento do Adolescente , COVID-19 , SARS-CoV-2 , Comportamento Sexual , Humanos , COVID-19/psicologia , COVID-19/epidemiologia , COVID-19/prevenção & controle , Adolescente , Feminino , Masculino , Comportamento Sexual/psicologia , Comportamento do Adolescente/psicologia , Adulto Jovem , Adulto , Estudos Longitudinais , Consumo de Bebidas Alcoólicas/psicologia , Consumo de Bebidas Alcoólicas/epidemiologia , Estados Unidos/epidemiologia , Consumo de Álcool por Menores/psicologia , Consumo de Álcool por Menores/estatística & dados numéricos , Pandemias
2.
Environ Res ; 231(Pt 2): 116107, 2023 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-37187310

RESUMO

Dyslipidemia, an imbalance of lipids and a major risk factor for cardiovascular disease, has been associated with elevated blood and urine levels of several heavy metals. Using data from a Canadian Health Measures Survey (CHMS), we tested associations between blood levels of cadmium, copper, mercury, lead, manganese, molybdenum, nickel, selenium, and zinc, and the lipids triglycerides (TG), total cholesterol (TC), low density lipoproteins (LDL), high density lipoproteins (HDL) and apolipoproteins A1 (APO A1), and B (APO B). All adjusted associations between single metals and lipids were positive and significant, except for APO A1 and HDL. The joint effect of an interquartile range increase in heavy metals was positively associated with percentage increases of TC, LDL and APO B of 8.82% (95%CI: 7.06, 10.57), 7.01% (95%CI: 2.51, 11.51) and 7.15% (95%CI: 0.51, 13.78), respectively. Future studies are warranted to determine if reducing environmental exposure to heavy metals favorably influences lipid profiles and the risk of cardiovascular disease.


Assuntos
Doenças Cardiovasculares , Lipoproteínas , Humanos , Lipídeos , Apolipoproteína A-I , Doenças Cardiovasculares/etiologia , Estudos Transversais , Canadá , Apolipoproteínas B , Triglicerídeos , HDL-Colesterol
3.
BMC Psychiatry ; 23(1): 940, 2023 12 13.
Artigo em Inglês | MEDLINE | ID: mdl-38093256

RESUMO

BACKGROUND: The current study aims to better understand the mental health and subjective well-being of investigators and forensic examiners exposed to child sexual abuse material (CSAM) by examining which components of this work are associated with elevated mental health conditions and decreased well-being, as well as the intra-personal and organizational variables that may mitigate harm and improve well-being. METHODS: Police investigators, forensic examiners, and others connected with the criminal justice system from across the United States who were exposed to CSAM as part of their professions (N = 500) completed an anonymous online survey. Participants were recruited through connections with the National Criminal Justice Training Center. RESULTS: Duration, frequency, amount, and content of CSAM exposure was not related to poorer mental health with the exception of exposure to violent CSAM which was related to elevated post-traumatic stress symptoms. Several agency-level practices and policies, such as the availability of an Officer Wellness Program and more frequently knowing the final case resolution, were related to better mental health and well-being. Harm mitigation strategies, such as talking to other officers investigating the case and taking breaks from the material being viewed, were also related to better mental health. CONCLUSIONS: Findings indicate that police agencies have options for implementing agency-level procedures and practices that have the potential to reduce the negative impact of CSAM investigations. Additionally, many investigators use strategies that are correlated with greater well-being, suggesting opportunities for improving training programs.


Assuntos
Abuso Sexual na Infância , Maus-Tratos Infantis , Criança , Humanos , Estados Unidos , Saúde Mental , Polícia/psicologia , Direito Penal
4.
Proc Natl Acad Sci U S A ; 117(23): 12772-12783, 2020 06 09.
Artigo em Inglês | MEDLINE | ID: mdl-32467166

RESUMO

The luteinizing hormone surge is essential for fertility as it triggers ovulation in females and sperm release in males. We previously reported that secretoneurin-a, a neuropeptide derived from the processing of secretogranin-2a (Scg2a), stimulates luteinizing hormone release, suggesting a role in reproduction. Here we provide evidence that mutation of the scg2a and scg2b genes using TALENs in zebrafish reduces sexual behavior, ovulation, oviposition, and fertility. Large-scale spawning within-line crossings (n = 82 to 101) were conducted. Wild-type (WT) males paired with WT females successfully spawned in 62% of the breeding trials. Spawning success was reduced to 37% (P = 0.006), 44% (P = 0.0169), and 6% (P < 0.0001) for scg2a-/- , scg2b-/- , and scg2a-/-;scg2b-/- mutants, respectively. Comprehensive video analysis indicates that scg2a-/-;scg2b-/- mutation reduces all male courtship behaviors. Spawning success was 47% in saline-injected WT controls compared to 11% in saline-injected scg2a-/-;scg2b-/- double mutants. For these mutants, spawning success increased 3-fold following a single intraperitoneal (i.p.) injection of synthetic secretoneurin-a (P = 0.0403) and increased 3.5-fold with injection of human chorionic gonadotropin (hCG). Embryonic survival at 24 h remained on average lower in scg2a-/-;scg2b-/- fish compared to WT injected with secretoneurin-a (P < 0.001). Significant reductions in the expression of gonadotropin-releasing hormone 3 in the hypothalamus, and luteinizing hormone beta and glycoprotein alpha subunits in the pituitary provide evidence for disrupted hypothalamo-pituitary function in scg2a and scg2b mutant fish. Our results indicate that secretogranin-2 is required for optimal reproductive function and support the hypothesis that secretoneurin is a reproductive hormone.


Assuntos
Fertilidade , Preferência de Acasalamento Animal , Mutação , Secretogranina II/genética , Proteínas de Peixe-Zebra/genética , Animais , Feminino , Hormônio Liberador de Gonadotropina/metabolismo , Hipotálamo/metabolismo , Hormônio Luteinizante/metabolismo , Masculino , Neuropeptídeos/metabolismo , Oviposição , Ovulação , Hipófise/metabolismo , Secretogranina II/metabolismo , Peixe-Zebra , Proteínas de Peixe-Zebra/metabolismo
5.
Am J Community Psychol ; 71(3-4): 344-354, 2023 06.
Artigo em Inglês | MEDLINE | ID: mdl-36609746

RESUMO

The purpose of the current study was to examine the diffusion effects of a youth-led sexual violence prevention program (i.e., Youth Voices in Prevention [Youth VIP]). Specifically, social network analysis was used to measure the extent to which Youth VIP changed behaviors for 1172 middle and high school youth who did not attend program events but were friends with Youth VIP participants and completed the first and final survey (approximately 2 years apart). Findings suggest that there was considerable interpersonal communication about Youth VIP among the students generated by program participation. Specifically, youth with friends who participated in Youth VIP were more likely to report hearing their friends talk about Youth VIP and reported talking to their friends about Youth VIP compared with those not connected to Youth VIP participants. However, there were no diffusion effects found for behavioral outcomes (i.e., bystander intervention behavior, violence victimization, and perpetration). Given the mixed findings, further research is needed to determine the extent to which youth-led sexual violence prevention initiatives lead to changes in broader community-wide changes in youths' behaviors.


Assuntos
Vítimas de Crime , Delitos Sexuais , Humanos , Adolescente , Adulto , Delitos Sexuais/prevenção & controle , Violência/prevenção & controle , Comportamento Sexual , Instituições Acadêmicas
6.
Prev Sci ; 23(7): 1230-1240, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35230613

RESUMO

Self-directed violence (SDV) is a significant public health issue for adolescents and emerging adults, and yet youth exposure to prevention messaging and youth perspectives on SDV prevention needs are understudied. The current study sought to better understand the ways in which a national sample of youth and emerging adults were exposed to suicide prevention programs or conversations. A sample of 1031 young people ages 13-23 were recruited nationally through social media. Survey questions asked about SDV prevention exposure. Open-ended questions asked youth to suggest additional information they desired about SDV. A majority of participants (87%) reported that they had received prevention exposure from at least one source (i.e., family, online, attending a talk, or formal program) with few differences by demographic characteristics. However, sexual and gender minority (SGM) youth reported accessing more SDV prevention information online compared to other youth. Overall, youth had many ideas about what additional information they needed, including how to help someone at risk for SDV and how to access information about mental health. While the majority of youth are receiving some SDV prevention messages, there is variation in how they get this information, and survey participants still felt they were missing important information. Findings highlight the need to resource more comprehensive SDV prevention for youth and young adults.


Assuntos
Comportamento do Adolescente , Prevenção do Suicídio , Adolescente , Comportamento do Adolescente/psicologia , Adulto , Humanos , Motivação , Comportamento Sexual , Violência , Adulto Jovem
7.
Prev Sci ; 23(8): 1379-1393, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35303249

RESUMO

Involving youth in developing and implementing prevention programs to reduce sexual violence (SV) has the potential to improve prevention outcomes. However, there has been little focus on youth-led SV prevention programs, and limited evaluation research to help guide efforts. The current study examined the effectiveness of Youth Voices in Prevention (Youth VIP) leadership retreats on SV victimization and perpetration, forms of violence related to SV (e.g., bullying), SV bystander behaviors and readiness, and perceptions of norms related to SV prevention. Results identified mixed findings for program impact, with variations in outcomes that can help guide future youth-led prevention program initiatives. Youth attending a large "kick-off" leadership retreat (that was less youth-led that subsequent smaller retreats) later reported more bystander behaviors, but also reported increased perpetration and victimization, compared to non-attending youth. However, youth attending smaller, more focused leadership retreats held during the school year, reported reductions in sexual harassment perpetration and improved bystander behaviors and attitudes compared to non-attending youth. Evaluation of moderator variables suggests that program impact was generally stronger for younger participants, sexual minority youth, and non-White youth (which were largely Native American youth in this sample). Findings suggest promise for youth-led prevention work but also highlight the need for testing the impact of different training structures and modalities. Clinical trials number: NCT03207386.


Assuntos
Vítimas de Crime , Delitos Sexuais , Assédio Sexual , Adolescente , Humanos , Liderança , Delitos Sexuais/prevenção & controle , Violência/prevenção & controle , Assédio Sexual/prevenção & controle
8.
Violence Vict ; 37(2): 222-243, 2022 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-35264454

RESUMO

A coordinated response by a trained multidisciplinary team (MDT) can help support child sex trafficking (CST) victims, but little is known about factors that influence the development and sustainability of MDTs in this work. An online survey was conducted with 171 professionals who attended a Multidisciplinary Team Child Sex Trafficking (MDT-CST) training to identify factors related to team growth. Increased MDT success was related to: (1) the presence of a CST-specific advocacy organization in the community; (2) other community agencies active in supporting CST victims (e.g., SANE nurses, faith-based organizations, and runaway shelters); (3) a greater breadth of professional representation on the MDT; and (4) agency leadership support for the CST action plan. Most of the MDTs sustained and increased their coordination with other community agencies over time, but the study identified that growth is improved when administrators support team efforts and there are resources and supports for CST victims elsewhere in the community.


Assuntos
Tráfico de Pessoas , Criança , Família , Humanos , Equipe de Assistência ao Paciente , Inquéritos e Questionários
9.
Am J Transplant ; 21(11): 3734-3742, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34212479

RESUMO

Trials describing 4- to 12-week courses of direct-acting antiviral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant recipients (D+/R- transplants) may be limited in "real-world" application by costs and delayed access to DAAs. We previously reported HCV transmission of 13% among D+/R- transplants with 2- to 4-day pangenotypic sofosbuvir/velpatasvir (SOF/VEL) perioperative prophylaxis, where one patient with HCV transmission was a nonresponder to first-line full-course DAA. Here, we report new data with a 7-day prophylaxis protocol (N = 50), as well as cumulative treatment and outcome data on all HCV D+/R- transplants (N = 102). Overall, nine patients (9/102; 9%; 95% CI: 5%-16%) developed HCV transmission, with a significant decline noted in the 7-day group (2/50; 4%; 95% CI: 0%-13%) compared with 2- to 4-day prophylaxis (7/52; 13%; 95% CI: 5%-25%). All patients with HCV transmission achieved sustained virologic response post full-course therapy (including one nonresponder from initial trial). A 1:1 matched analysis (N = 102) with contemporary HCV D-/R- transplants (controls) showed that although the pretransplant wait time was significantly shorter for D+/R- compared with D-/R- (mean: 1.8 vs. 4.4 years; p < .001), there were no differences in infections, rejection, development of de novo donor-specific antibody, or transplant outcomes up to 6 months of transplant.


Assuntos
Antivirais , Hepatite C , Transplante de Rim , Antivirais/uso terapêutico , Carbamatos/uso terapêutico , Combinação de Medicamentos , Hepacivirus , Hepatite C/tratamento farmacológico , Hepatite C/prevenção & controle , Compostos Heterocíclicos de 4 ou mais Anéis/uso terapêutico , Humanos , Transplante de Rim/efeitos adversos , Sofosbuvir/uso terapêutico
10.
J Sex Med ; 18(7): 1245-1257, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34176755

RESUMO

INTRODUCTION: Despite studies showing that individuals with insecure attachment suffer from poor body image, and that poor body image is a main risk factor for sexual dysfunction, the mediating role of body image between attachment insecurities and sexual functioning has not been assessed. Moreover, differences in body self-consciousness among sexual minority women have not been examined, even though LGB individuals have been found to be more conscious of stigma and the disapproval of others. AIM: To fill this gap, the current study examines the mediating role of body image self-consciousness between insecure attachment and sexual functioning among LGB and non-LGB women. METHODS: The study sample consisted of 1,001 women; of them, 808 defined themselves as heterosexual (80.7%), and 193 (19.3%) identified as LGB. The sample was a convenience sample of women who responded to ads on social media. Participants completed an online questionnaire (via Qualtrics) about their attachment orientation, body-image self-consciousness, and sexual functioning. MAIN OUTCOME: Body image self-consciousness mediated the relationship between insecure attachment and sexual dysfunction among women in general and LGB women in particular. RESULTS: Results indicated that among LGB women, the relationship between attachment and sexual functioning was fully mediated by body image self-consciousness. For non-LGB women, a full model with statistically significant direct and indirect effects was revealed. Both avoidant attachment and anxious attachment were related to body image self-consciousness which was, in turn, related to sexual functioning. A statistically significant direct path from avoidant attachment to sexual functioning was also revealed. CONCLUSION: The study findings contribute to the literature by revealing the mediating role that body image self-consciousness plays between insecure attachment and sexual dysfunction among women in general and LGB women in particular. CLINICAL IMPLICATIONS: This study provides support for the negative relationship between body image self-consciousness and sexual functioning of women regardless of sexual orientation, and suggests that women affected by body image concerns might be prone to more sexual dysfunction. Therefore, body image self-consciousness should be brought up in sex therapy sessions and future interventions. Clinicians should also be cognizant of differences between LGB and non-LGB women in terms of this effect, taking into account the history of stigma that LGB women may have endured and how this history affects their body image. Gewirtz-Meydan A, Mitchell KJ, Spivak-Lavi Z. Attachment and Sexual Functioning: Understanding the Mediating Role of Body Image Among LGB and Non-LGB Women. J Sex Med 2021;18:1245-1257.


Assuntos
Imagem Corporal , Minorias Sexuais e de Gênero , Feminino , Heterossexualidade , Humanos , Masculino , Comportamento Sexual , Inquéritos e Questionários
11.
J Pediatr Nurs ; 59: 37-44, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33460878

RESUMO

PURPOSE: To provide information from a large sample of pediatric and family medicine primary care providers on practices in screening children for behavioral health risks. DESIGN AND METHODS: Participants were a sample of physicians (n=319) and nurse practitioners (n=292) from across the U.S. who completed a confidential online survey about screening practices through a computer-assisted self-interview. RESULTS: Almost all respondents (89%) reported screening children for depression/anxiety and behavior problems. Child substance use (82%), family social support (74%), significant household changes (73%), bullying (72%), child abuse (62%) and domestic violence (52%) were also asked about regularly, although with high rates of informal screening methods. Caregiver mental health (49%), caregiver substance use (35%), family financial strain (33%) and transportation difficulties (27%) were screened less frequently. Screening was associated with higher rates of referral for risk-related problems, and was more likely when providers reported greater confidence providing support to clients, perceived community resource availability as higher, and worked in systems with integrated primary care and behavioral health. CONCLUSIONS: Findings suggest a great amount of diversity in how providers screen for behavioral health risks. There is reluctance to screen when options for addressing the problems are seen as limited. Research is needed to better guide healthcare providers in determining the right context and methods for screening social risks. PRACTICE IMPLICATIONS: Protocols for screening adverse childhood events (ACES) and other social risk factors should be accompanied by adequate training and efforts to improve community resource and support networks.


Assuntos
Maus-Tratos Infantis , Atenção Primária à Saúde , Criança , Humanos , Programas de Rastreamento , Encaminhamento e Consulta , Inquéritos e Questionários
12.
J Youth Adolesc ; 50(8): 1521-1536, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34128143

RESUMO

Little is known about the characteristics and context of adolescent relationship abuse victimization across youth of different sexual and gender minority identities. This study sought to examine this in a national sample of 14-15-year-old youth. The sample comprised 3296 youth who reported having been in a relationship, of which 36% (n = 1197) were exclusively cisgender heterosexual; 41% (n = 1, 349) cisgender sexual minority; and 23% (n = 750) gender minority, the majority of whom were also sexual minority. More than half of all youth who had been in a relationship, dated or hooked up with someone had experienced some form of adolescent relationship abuse victimization. Gender minority youth, in particular transgender boys and non-binary youth assigned female at birth, were more likely to be victims of multiple types of adolescent relationship abuse compared to cisgender youth. Perpetrator gender varied for sexual and gender minorities and was more homogenous for cisgender heterosexual youth. Several factors were associated with adolescent relationship abuse for all youth, although alcohol use, and parental trust and communication emerged as particularly important for sexual and gender minority youth. Overall, findings address multiple gaps in the literature and contribute to the understanding of adolescent relationship abuse across different sexual and gender identities.


Assuntos
Bullying , Vítimas de Crime , Minorias Sexuais e de Gênero , Adolescente , Feminino , Identidade de Gênero , Humanos , Masculino , Fatores de Proteção , Comportamento Sexual
13.
Violence Vict ; 36(2): 251-271, 2021 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-33361446

RESUMO

Research on cyber-victimization has primarily focused on cyberbullying conducted in urban and suburban (metropolitan) settings. We explore a range of cyber-victimizations, including financially motivated offenses and cyberbullying, and their associations with current psychological and health status in a nonmetropolitan sample from southern Appalachia. The forms of cyber-victimization were drawn from focus groups and interviews, and then self-report data on 14 types of cyber-victimization were collected from 478 individuals (57.1% female; age M = 36.44, SD = 16.61). Approximately 3 out of 4 participants (74.7%) reported experiencing at least one cyber-victimization. Cyber-victimization made many participants feel "very upset" (average 55.7%). Many forms of cyber-victimization were associated with elevated trauma symptoms, and lower subjective well-being and health-related quality of life. Cyber-victimization is common in this southern Appalachian community, with financially motivated incidents leading to higher prevalence rates than found in many other studies. In these data, numerous specific types of victimization, including cyber-theft, fraud, and legal-but-intrusive privacy invasions, were associated with worse psychological and physical health. More research is needed on technology-mediated victimization and these types of victimization should be more routinely included in violence assessments.


Assuntos
Bullying , Vítimas de Crime , Cyberbullying , Bullying/psicologia , Vítimas de Crime/psicologia , Cyberbullying/psicologia , Feminino , Nível de Saúde , Humanos , Masculino , Qualidade de Vida
14.
Clin Gerontol ; 44(3): 316-330, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33685368

RESUMO

Objectives: To explore relationships between sexual activity and depressive symptoms in urology and gynecology out-patients aged 50 years and older.Methods: Depressive symptoms were assessed using Zung Self-Rating Depression Scale. Sexual activity was measured by interviewer-administered questionnaires assessing relationships, intimacy and sexual function (N = 557). Aging and sexual activity were discussed in focus groups (N = 52).Results: More men (51%) than women (41%) reported engagement in sexual intercourse and approximately 40% of men reported sexual activities in the past 4 weeks. The mean number of sex-related complaints per woman was 1.5 (Standard Deviation, 1.2). Approximately four of every ten men reported difficulty with erectile function. Men placed high value on sexual intercourse while women also embraced other activities. After controlling for demographic and health variables, men who reported sexual activity in the past 4 weeks had depressive symptom scores approximately five points lower than those who reported no sexual activity. Each additional sexual complaint was associated with a two-point increase in depressive symptoms scores in women.Conclusions: Higher depressive symptom scores are associated with reduced sexual activity in men and increased sexual complaints in women. Sexual activities remain important for older adults, despite declining sexual function and men place higher value on sexual intercourse than women.Clinical implications: Mental health assessments and sexual activity history should be included in routine healthcare consultations in persons 50 and over.


Assuntos
Depressão , Comportamento Sexual , Idoso , Envelhecimento , Feminino , Humanos , Jamaica , Masculino , Parceiros Sexuais
15.
Gen Comp Endocrinol ; 299: 113588, 2020 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-32828813

RESUMO

Secretogranin-2 (SCG2) is a large precursor protein that is processed into several potentially bioactive peptides, with the 30-43 amino acid central domain called secretoneurin (SN) being clearly evolutionary conserved in vertebrates. Secretoneurin exerts a diverse array of biological functions including regulating nervous, endocrine, and immune systems in part due to its wide tissue distribution. Expressed in some neuroendocrine neurons and pituitary cells, SN is a stimulator of the synthesis and release of luteinizing hormone from both goldfish pituitary cells and the mouse LßT2 cell line. Neuroendocrine, paracrine and autocrine signaling pathways for the stimulation of luteinizing hormone release indicate hormone-like activities to regulate reproduction. Mutation of the scg2a and scg2b genes using TALENs in zebrafish reduces sexual behavior, ovulation, oviposition, and fertility. A single injection of the SNa peptide enhanced reproductive outcomes in scg2a/scg2b double mutant zebrafish. Evidence in goldfish suggests a new role for SN to stimulate food intake by actions on other feeding-related neuropeptides. Expression and regulation of the Scg2a precursor mRNA in goldfish gut also supports a role in feeding. In rodent models, SN has trophic-like properties promoting both neuroprotection and neuronal plasticity and has chemoattractant properties that regulate neuroinflammation. Data obtained from several cellular models suggest that SN binds to and activates a G-protein coupled receptor (GPCR), but a bona fide SN receptor protein needs to be identified. Other signaling pathways for SN have been reported which provides alternatives to the GPCR hypothesis. These include AMP-activated protein kinase (AMPK), extracellular signal-regulated kinases (ERK), mitogen-activated protein kinase (MAPK)and calcium/calmodulin-dependent protein kinase II in cardiomyocytes, phosphatidylinositol 3-kinase (PI3K) and Akt/Protein Kinase B (AKT, and MAPK in endothelial cells and Janus kinase 2/signal transducer and activator of transcription protein (JAK2-STAT) signaling in neurons. Some studies in cardiac cells provide evidence for cellular internalization of SN by an unknown mechanism. Many of the biological functions of SN remain to be fully characterized, which could lead to new and exciting applications.


Assuntos
Neuropeptídeos/metabolismo , Secretogranina II/metabolismo , Sequência de Aminoácidos , Animais , Feminino , Carpa Dourada , Humanos , Masculino , Camundongos , Peixe-Zebra
16.
J Pediatr Nurs ; 50: 46-53, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31756596

RESUMO

PURPOSE: Most children are exposed to violence (e.g., peer, family, or community violence), which makes children's exposure to violence one of our most urgent social problems. The objective of this project was to examine health-related quality of life (HRQOL) in a vulnerable community sample and identify promising psychological and social protective factors to promote HRQOL in youth. DESIGN AND METHODS: The sample was 440 youth ages 10 to 21 (average age 16.38, SD = 3.04), recruited from youth-serving organizations. Participants completed a survey on HRQOL, victimization, other adversities, and a range of 16 psychological and social strengths. RESULTS: Almost 9 in 10 (89.3%) youth reported at least one victimization during their lifetime, and impaired HRQOL was common, with more than half reporting some health impairment in the month prior to the survey. Although all psychological and social strengths were positively correlated with HRQOL at the bivariate level, hierarchical regression indicated that a sense of purpose and recovering positive affect uniquely contributed to better HRQOL, after controlling for victimization, other adversities, poverty, age, and gender (total R2 = 0.21). Strengths accounted for more variance in HRQOL than did adversities. CONCLUSIONS: In this highly victimized sample of youth, many strengths were associated with improved HRQOL for youth, with sense of purpose and recovering positive affect showing the most promise for future prevention and intervention. PRACTICAL IMPLICATIONS: Programs aimed at reducing the negative impact of childhood exposure to violence may increase their impact by developing key strengths versus solely focusing on alleviating symptoms.


Assuntos
Maus-Tratos Infantis/psicologia , Vítimas de Crime/psicologia , Vítimas de Crime/estatística & dados numéricos , Exposição à Violência/psicologia , Qualidade de Vida , Atividades Cotidianas , Adolescente , Afeto , Criança , Maus-Tratos Infantis/estatística & dados numéricos , Exposição à Violência/estatística & dados numéricos , Feminino , Humanos , Masculino , Medição da Dor , Resiliência Psicológica , Adulto Jovem
17.
Am J Community Psychol ; 65(1-2): 160-172, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31449675

RESUMO

The purpose of the current study was to examine the impact of exposure to Bringing in the Bystander-High School Curriculum (BITB-HSC) on school personnel, which included a seven session classroom curriculum for ninth through twelfth graders (student curriculum), a bystander training workshop for school personnel (school personnel workshop), and reading materials (handout). We examined how exposure to these various BITB-HSC intervention components was associated with school personnel's knowledge and bystander efficacy, intentions, and barriers specific to student relationship abuse (RA) and sexual assault (SA). Participants were 488 school personnel from 12 high schools in upper New England who completed the 4-month follow-up survey that assessed for intervention exposure (284 participants completed both the baseline and follow-up survey). Whereas 53% of participants were exposed to no intervention components, the other half of the sample were exposed to a combination of intervention components. Higher baseline knowledge and reactive bystander intentions were associated with subsequent exposure to both the student curriculum and the handout, and fewer barriers to bystander action predicted exposure to the school personnel workshop. Exposure to the school personnel workshop, student curriculum, and handout was associated with subsequent greater knowledge, exposure to the student curriculum predicted reactive bystander intentions, and exposure to the handout predicted higher reactive bystander intentions and bystander efficacy. Findings suggest that despite challenges with engagement, exposure to the BITB-HSC components may be a useful tool in improving school personnel's responses to RA and SA among high school students.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Promoção da Saúde/métodos , Professores Escolares/psicologia , Delitos Sexuais/prevenção & controle , Estudantes/psicologia , Adolescente , Adulto , Idoso , Vítimas de Crime/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , New England , Instituições Acadêmicas , Delitos Sexuais/psicologia , Adulto Jovem
18.
J Youth Adolesc ; 49(3): 735-746, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32002715

RESUMO

Adolescence is a high-risk time for perpetration of different forms of peer-based violence including harassment, bullying, and sexual assault. Research documents a number of important risk factors but less understood are protective factors like sense of mattering or how combinations of strengths may reduce perpetration risk. The current study examined how protective factors (i.e., positive social norms), including a diversity of strengths (termed poly-strengths), influenced the perpetration of harassment, bullying, and sexual assault for young people, while accounting for the use of alcohol both cross-sectionally and over time. Youth (N = 2232, 52.6% female) in grades 7-10 enrolled in a study using active parental consent (53% response rate) and completed online surveys in school that asked about bullying and harassment, alcohol use, positive social norms related to violence prevention, and a composite of intra-personal strengths. Follow-up surveys took place 6 months later (N = 2150). Logistic regression analyses examined how social norms and poly-strengths influenced odds of perpetration after accounting for demographic variables and the risk factor of alcohol use. Use of alcohol increased the odds of perpetrating all forms of violence. Strengths were significantly related to lower perpetration at Time 1 but not Time 2. Positive social norms reduced perpetration at both time points. The findings suggest adolescent perpetration of bullying, harassment, and sexual violence is lower in the presence of positive social norms over time and more proximally, in the presence of a diverse strengths portfolio. Prevention efforts that incorporate positive social norms and alcohol reduction strategies may reduce peer violence.


Assuntos
Comportamento do Adolescente/psicologia , Bullying/psicologia , Grupo Associado , Delitos Sexuais/psicologia , Assédio Sexual/psicologia , Normas Sociais , Adaptação Psicológica , Adolescente , Bullying/prevenção & controle , Estudos Transversais , Feminino , Humanos , Estudos Longitudinais , Masculino , Fatores de Proteção , Psicologia do Adolescente , Fatores de Risco , Instituições Acadêmicas , Autoimagem , Delitos Sexuais/prevenção & controle , Assédio Sexual/prevenção & controle , Apoio Social , Espiritualidade , Inquéritos e Questionários
19.
J Youth Adolesc ; 49(10): 1961-1975, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32829423

RESUMO

Research has documented that a significant portion of youth are exposed to bias victimization. However, less is known about whether experiencing certain types of bias victimization (e.g., sexual orientation bias) is more or less likely to be related to a more extensive bias victimization history (i.e., experiencing multiple types of bias victimization) and whether exposure to multiple types of bias victimization explains any relationships between specific types of bias victimization and negative outcomes. To address these gaps, the current study explores relationships between exposure to multiple types of bias-motivated victimization, trauma symptomatology and perceived social support. Participants were 854 youth and young adults (60.9% female) from three higher risk communities who completed a survey on personal experiences with bias-related victimization. The average age of participants was 16.6 years; 28.5% of the sample described themselves as Black or African American; 13.4% as Hispanic or Latino (any race); 45.3% as White, and 12.8% as another race. Sixty-nine percent of the sample described their sexual orientation as heterosexual; 8.9% as gay, lesbian, or homosexual; 12.5% as bisexual; and 9.5% as another sexual orientation. Sixty-three percent of participants reported at least one type of bias victimization in their lifetime, and more than one in three youth (38.7%) experienced two or more types of bias victimization in their lifetimes (18.1% two types, 12.1% three types, and 8.5% four or more types). Experiencing multiple types of bias victimization was related to higher trauma symptomatology and less perceived social support. Experiencing multiple types of bias victimization attenuated or eliminated the association between individual types of bias victimization and well-being. The findings contribute to a growing body of research demonstrating the damaging mental health effects of occupying multiple marginalized statuses, and points to the cumulation of bias victimization experiences as an important factor contributing to significant differences in well-being and support among youth and young adults.


Assuntos
Bullying , Vítimas de Crime , Homossexualidade Feminina , Adolescente , Bissexualidade , Feminino , Humanos , Masculino , Apoio Social , Adulto Jovem
20.
Violence Vict ; 35(2): 143-159, 2020 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-32273374

RESUMO

Using a nationally representative sample of 791 youth, ages 8-17 at baseline, this study identified patterns over a 2-year period in specific forms of peer victimization and examined differences in the mental health consequences of those patterns. Findings show that, among the victimized, physical assault had relatively high persistence compared to other forms, while physical intimidation and emotional bullying had relatively high rates of desistence. Emotional bullying at T1 was associated with increased risk of T2 Internet harassment and Internet harassment at T1 strongly predicted T2 dating violence. Patterns of victimization over time differed in their relationship with trauma symptoms. Findings emphasized the importance of recency and the distress of new victimization experiences, rather than the chronicity or repetition of victimization. Understanding variations in peer victimization patterns and outcomes over time can help to inform interventions that better target sources of risk across adolescence.


Assuntos
Comportamento do Adolescente , Bullying , Vítimas de Crime , Adolescente , Comportamento do Adolescente/psicologia , Bullying/psicologia , Criança , Vítimas de Crime/psicologia , Humanos , Estudos Longitudinais , Saúde Mental
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