Detalhe da pesquisa
1.
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Cell
; 145(6): 863-74, 2011 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21640374
2.
Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice.
Biochim Biophys Acta
; 1860(11 Pt A): 2345-2354, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27392942
3.
Kynurenines in the mammalian brain: when physiology meets pathology.
Nat Rev Neurosci
; 13(7): 465-77, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22678511
4.
Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain.
J Biol Chem
; 288(51): 36554-66, 2013 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24189070
5.
Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.
Hum Mol Genet
; 21(11): 2432-49, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357655
6.
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease.
Nat Genet
; 37(5): 526-31, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15806102
7.
Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease.
J Neurosci
; 32(50): 18259-68, 2012 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23238740
8.
Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease.
J Neurosci
; 32(1): 133-42, 2012 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22219276
9.
Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.
J Neurosci
; 32(32): 11109-19, 2012 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22875942
10.
Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.
J Biol Chem
; 287(19): 16017-28, 2012 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22433867
11.
Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Nat Chem Biol
; 7(12): 925-34, 2011 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22037470
12.
Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.
J Biol Chem
; 286(1): 410-9, 2011 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21044956
13.
Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease.
Hum Mol Genet
; 19(1): 65-78, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19825844
14.
Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
J Biol Chem
; 285(19): 14777-90, 2010 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20220138
15.
Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle.
J Biol Chem
; 285(49): 38183-93, 2010 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20864533
16.
Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.
J Neurosci
; 29(28): 9104-14, 2009 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19605647
17.
Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease.
J Neurochem
; 113(6): 1416-25, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20236387
18.
Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease.
J Neurosci
; 28(2): 465-72, 2008 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18184789
19.
Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer.
Nat Struct Mol Biol
; 11(12): 1215-22, 2004 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15543156
20.
Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease.
Methods Mol Biol
; 548: 161-74, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19521824