Detalhe da pesquisa
1.
Probing Enzymatic PET Degradation: Molecular Dynamics Analysis of Cutinase Adsorption and Stability.
J Chem Inf Model
; 64(10): 4112-4120, 2024 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38703106
2.
S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors.
Molecules
; 28(13)2023 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446746
3.
1,2,4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-ß-lactamase inhibitors.
Bioorg Med Chem
; 72: 116964, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36030663
4.
Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines.
Molecules
; 27(17)2022 Aug 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36080340
5.
QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle.
J Chem Inf Model
; 61(7): 3502-3515, 2021 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34161071
6.
4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-ß-lactamase inhibitors.
Bioorg Chem
; 113: 105024, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34116340
7.
Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest.
Bioorg Chem
; 94: 103347, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31810757
8.
NCα-gem-dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics.
Biopolymers
; 110(6): e23273, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30897209
9.
Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies.
Bioorg Med Chem
; 27(10): 2083-2089, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30967303
10.
Synthesis of Branched-Chain Sugars with a DHAP-Dependent Aldolase: Ketones are Electrophile Substrates of Rhamnulose-1-phosphate Aldolases.
Angew Chem Int Ed Engl
; 57(19): 5467-5471, 2018 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29542859
11.
Insights into the Thiamine Diphosphate Enzyme Activation Mechanism: Computational Model for Transketolase Using a Quantum Mechanical/Molecular Mechanical Method.
Biochemistry
; 55(14): 2144-52, 2016 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26998737
12.
Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives.
Bioorg Med Chem Lett
; 26(17): 4327-9, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27469128
13.
Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.
Bioorg Med Chem
; 24(14): 3116-24, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255178
14.
Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition.
Bioorg Med Chem
; 22(17): 4704-10, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25087047
15.
New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities.
Bioorg Chem
; 57: 108-115, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25305721
16.
Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles.
Eur J Med Chem
; 269: 116352, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38537512
17.
Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.
Bioorg Med Chem Lett
; 23(8): 2298-301, 2013 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23499503
18.
Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors.
Bioorg Med Chem
; 21(14): 4102-11, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23735828
19.
Cage-like structures based on constrained cyclic arylopeptoids.
Chem Commun (Camb)
; 59(52): 8087-8090, 2023 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37293700
20.
Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA).
Eur J Med Chem
; 244: 114809, 2022 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36208509