Detalhe da pesquisa
1.
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
Bioorg Med Chem Lett
; 72: 128856, 2022 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35728998
2.
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 67(10): 8122-8140, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712838
3.
Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.
J Med Chem
; 64(9): 6358-6380, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33944571
4.
Synthesis of a 10-Membered Carbocycle By Olefin Metathesis.
Angew Chem Int Ed Engl
; 40(21): 4060-4062, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29712259
5.
Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell line.
Org Lett
; 16(21): 5560-3, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25376106
6.
A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton.
Angew Chem Int Ed Engl
; 41(11): 1941-5, 2002 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19750640
7.
Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle.
Angew Chem Int Ed Engl
; 42(29): 3418-24, 2003 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12888975
8.
Synthesis of a 10-Membered Carbocycle By Olefin Metathesis Financial support has been provided by the Academy of Finland and HUT.
Angew Chem Int Ed Engl
; 40(21): 4060-4062, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12404492
9.
Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
J Med Chem
; 51(21): 6646-9, 2008 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18842035
10.
Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis.
J Am Chem Soc
; 127(31): 11176-83, 2005 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16076225
11.
Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks.
J Am Chem Soc
; 127(31): 11159-75, 2005 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16076224
12.
Total synthesis of nor-1,6-germacradien-5-ols.
J Org Chem
; 67(5): 1554-60, 2002 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11871886