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Am J Alzheimers Dis Other Demen ; 33(6): 353-361, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29607654

RESUMO

BACKGROUND: Being a carrier of the apolipoprotein E (APOE) ε4 allele is a clear risk factor for development of Alzheimer's disease (AD). On some neurocognitive tests, there are smaller differences between carriers and noncarriers, while other tests show larger differences. AIMS: We explore whether the size of the difference between carriers and noncarriers is a function of how well the tests measure general intelligence, so whether there are Jensen effects. METHODS: We used the method of correlated vectors on 441 Korean older adults at risk for AD and 44 with AD. RESULTS: Correlations between APOE carriership and test scores ranged from -.05 to .11 (normal), and -.23 to .54 (AD). The differences between carriers and noncarriers were Jensen effects: r = .31 and r = .54, respectively. CONCLUSION: A composite neurocognitive score may show a clearer contrast between APOE carriers and noncarriers than a large number of scores of single neurocognitive tests.


Assuntos
Doença de Alzheimer/genética , Apolipoproteína E4/genética , Disfunção Cognitiva/genética , Testes Neuropsicológicos/estatística & dados numéricos , Idoso , Feminino , Genótipo , Humanos , Masculino , República da Coreia , Fatores de Risco
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