Detalhe da pesquisa
1.
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Br J Cancer
; 117(1): 113-123, 2017 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28535155
2.
A recurrent mutation in PALB2 in Finnish cancer families.
Nature
; 446(7133): 316-9, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17287723
3.
Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.
Hum Mol Genet
; 19(15): 3021-9, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20484223
4.
Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper.
Clin Cancer Res
; 28(21): 4724-4736, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35929986
5.
Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance.
Clin Cancer Res
; 28(20): 4536-4550, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35921524
6.
Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development.
Mol Cancer Ther
; 20(9): 1614-1626, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34158341
7.
Mutation analysis of the AATF gene in breast cancer families.
BMC Cancer
; 9: 457, 2009 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20025740
8.
Penetrance analysis of the PALB2 c.1592delT founder mutation.
Clin Cancer Res
; 14(14): 4667-71, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18628482
9.
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity.
Nat Commun
; 10(1): 5065, 2019 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699977
10.
Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families.
BMC Cancer
; 8: 146, 2008 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-18501021
11.
BRD4 facilitates replication stress-induced DNA damage response.
Oncogene
; 37(28): 3763-3777, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29636547
12.
Heterozygous mutations in PALB2 cause DNA replication and damage response defects.
Nat Commun
; 4: 2578, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24153426
13.
Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions.
Sci Transl Med
; 4(122): 122ra23, 2012 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22357538
14.
Screening for large genomic rearrangements in the FANCA gene reveals extensive deletion in a Finnish breast cancer family.
Cancer Lett
; 302(2): 113-8, 2011 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21236561