Theories of Relativistic Dissipative Fluid Dynamics.

Relativistic dissipative fluid dynamics finds widespread applications in high-energy nuclear physics and astrophysics. However, formulating a causal and stable theory of relativistic dissipative fluid dynamics is far from trivial; efforts to accomplish this reach back more than 50 years. In this review, we give an overview of the field and attempt a comparative assessment of (at least most of) the theories for relativistic dissipative fluid dynamics proposed until today and used in applications.

Transient Relativistic Fluid Dynamics in a General Hydrodynamic Frame.

We propose a new theory of second-order viscous relativistic hydrodynamics which does not impose any frame conditions on the choice of the hydrodynamic variables. It differs from Mueller-Israel-Stewart theory by including additional transient degrees of freedom, and its first-order truncation reduces to Bemfica-Disconzi-Noronha-Kovtun theory. Conditions for causality and stability are explicitly given in the conformal regime. As an illustrative example, we consider Bjorken flow solutions to our equations and identify variables which make a hydrodynamic attractor manifest.

Novel Relaxation Time Approximation to the Relativistic Boltzmann Equation.

We show that the widely used relaxation time approximation to the relativistic Boltzmann equation contains basic flaws, being incompatible with micro- and macroscopic conservation laws if the relaxation time depends on energy or general matching conditions are applied. We propose a new approximation that fixes such fundamental issues and maintains the basic properties of the linearized Boltzmann collision operator. We show how this correction affects transport coefficients, such as the bulk viscosity and particle diffusion.

Nonlinear Constraints on Relativistic Fluids Far from Equilibrium.

New constraints are found that must necessarily hold for Israel-Stewart-like theories of fluid dynamics to be causal far away from equilibrium. Conditions that are sufficient to ensure causality, local existence, and uniqueness of solutions in these theories are also presented. Our results hold in the full nonlinear regime, taking into account bulk and shear viscosities (at zero chemical potential), without any simplifying symmetry or near-equilibrium assumptions. Our findings provide fundamental constraints on the magnitude of viscous corrections in fluid dynamics far from equilibrium.

Exact Hydrodynamic Attractor of an Ultrarelativistic Gas of Hard Spheres.

We derive the general analytical solution of the viscous hydrodynamic equations for an ultrarelativistic gas of hard spheres undergoing Bjorken expansion, taking into account effects from particle number conservation, and use it to analytically determine its attractor at late times. Differently than all the cases considered before involving rapidly expanding fluids, in this example the gradient expansion converges. We exactly determine the hydrodynamic attractor of this system when its microscopic dynamics is modeled by the Boltzmann equation with a fully nonlinear collision kernel. The exact late time attractor of this system can be reasonably described by hydrodynamics even when the gradients are large.

Effects of the addition of quantitative apparent diffusion coefficient data on the diagnostic performance of the PI-RADS v2 scoring system to detect clinically significant prostate cancer.

PURPOSE: To evaluate the impact of the addition of quantitative apparent diffusion coefficient (ADC) data into the diagnostic performance of the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) scoring system to predict clinically significant prostate cancer (CSPCa). METHODS: We retrospectively included 91 consecutive patients who underwent prostate multiparametric magnetic resonance imaging (mp-MRI) and histopathological evaluation. Mp-MRI images were reported by the PI-RADSv2 scoring system and patients were divided into groups considering the likelihood of CSPCa. ADC value and ratio were obtained. Findings were correlated with histopathological data. RESULTS: CSPCa was found in 41.8% of cases (n = 38). PI-RADSv2 score 3-5 yielded a sensitivity of 97.4% (95% confidence intervals 86.5-99.5), a specificity of 50.9% (37.9-63.9), and AUC of 0.74 (0.67-0.81) to predict CSPCa. ADC value < 750 µm2/s and an ADC ratio < 0.62 were the most accurate thresholds for differentiation of CSPCa, with AUC of 0.81 and 0.76, respectively. Combined PI-RADSv2 score 3-5 and ADC value < 750 µm2/s yielded a specificity of 84.9 (72.9-92.2), sensitivity of 70.3 (54.2-82.5), and AUC of 0.77 (0.68-0.86). Combined PI-RADSv2 score 3-5 and ADC ratio < 0.62 yielded a specificity of 86.5 (74.7-93.3), sensitivity of was 64.9 (48.8-78.2), and AUC of 0.75 (0.66-0.84). CONCLUSION: Quantitative ADC data might not be beneficial to be used routinely in mp-MR imaging as criteria to detect clinically significant lesions due to the reduced sensitivity. Instead, when prostate lesions present a PI-RADSv2 score ≥ 3, additional quantitative ADC criteria can be helpful to increase the PI-RADS score specificity.

Causality of the Einstein-Israel-Stewart Theory with Bulk Viscosity.

We prove that Einstein's equations coupled to equations of the Israel-Stewart-type, describing the dynamics of a relativistic fluid with bulk viscosity and nonzero baryon charge (without shear viscosity or baryon diffusion) dynamically coupled to gravity, are causal in the full nonlinear regime. We also show that these equations can be written as a first-order symmetric hyperbolic system, implying local existence and uniqueness of solutions to the equations of motion. We use an arbitrary equation of state and do not make any simplifying symmetry or near-equilibrium assumption, requiring only physically natural conditions on the fields. These results pave the way for the inclusion of bulk viscosity effects in simulations of gravitational-wave signals coming from neutron star mergers.

Serum tissue factor as a biomarker for renal clear cell carcinoma.

PURPOSE: to determine the usefulness of serum TF as a potential marker for patients with clear cell RCC. MATERIALS AND METHODS: prospective study of 30 patients with clear cell RCC submitted to nephrectomy and 16 controls without clear cell RCC treated surgically for other conditions. TF is a endothelium marker that was correlated with worse prognosis in a variety of solid tumors including RCC. Serum TF was collected before surgery at the operating room and in the postoperative setting after at least four weeks. Serum samples were analyzed with a commercial ELISA kit for human TF (R&D Systems®). RESULTS: Mean preoperative serum TF levels in clear cell RCC patients and in controls were 66.8 pg/dL and 28.4 pg/dL, respectively (p<0.001). Mean postoperative serum TF levels in clear cell RCC patients were 26.3 pg/dL. In all patients with clear cell RCC postoperative serum levels of TF were lower, with a mean reduction of 41.6 pg/dL in the postoperative setting (p<0.001). Linear regression revealed that tumor size was correlated with the postoperative reduction of serum TF levels (p=0.037). CONCLUSIONS: We have shown a 3-fold reduction in the median preoperative serum levels of TF in patients with clear cell RCC after surgery. We have also shown a difference of the same magnitude in the serum levels of TF compared with those of a control group of patients with benign diseases. TF appears to be a useful serum marker for the presence of clear cell RCC. Further studies are needed to validate these findings.

Gastric neobladders: surgical outcomes of 91 cases using different techniques.

INTRODUCTION: We report on the surgical results of a series of 91 patients who received gastric neobladders as urinary diversion after radical cystectomies performed for the treatment of muscle-invasive bladder cancers. MATERIALS AND METHODS: We report on a retrospective case series of 91 patients who received gastric neobladders as urinary diversion after radical cystectomies performed for the treatment of muscle-invasive bladder cancers. Different techniques of gastric neobladders were employed from 1988 to 2013 at a university hospital in the South of Brazil. RESULTS: Initial outcomes utilizing Leong (Antral) and Nguyen-Mitchell (Wedge) technique were unsatisfactory, yielding high pressure, low capacity reservoirs. Further developments of these techniques, with the detubularized gastric neobladder and the "spherical" gastric neobladders resulted in low pressure, high capacity reservoirs, with better surgical and urodynamic outcomes. Complication and perioperative mortality rates of our series of gastric neobladders were significantly higher than historical results of techniques using ileum or colon. CONCLUSIONS: Stomach is an exceptional option for the creation of neobladders after radical cystectomies, but due to the increased complication rates it should be reserved for specific situations (e.g., renal insufficiency, previous pelvic/abdominal radiotherapy, short bowel syndromes).

Event-by-Event Hydrodynamics+Jet Energy Loss: A Solution to the R_{AA}⊗v_{2} Puzzle.

High p_{T}>10 GeV elliptic flow, which is experimentally measured via the correlation between soft and hard hadrons, receives competing contributions from event-by-event fluctuations of the low-p_{T} elliptic flow and event-plane angle fluctuations in the soft sector. In this Letter, a proper account of these event-by-event fluctuations in the soft sector, modeled via viscous hydrodynamics, is combined with a jet-energy-loss model to reveal that the positive contribution from low-p_{T} v_{2} fluctuations overwhelms the negative contributions from event-plane fluctuations. This leads to an enhancement of high-p_{T}>10 GeV elliptic flow in comparison to previous calculations and provides a natural solution to the decade-long high-p_{T} R_{AA}⊗v_{2} puzzle. We also present the first theoretical calculation of high-p_{T} v_{3}, which is shown to be compatible with current LHC data. Furthermore, we discuss how short-wavelength jet-medium physics can be deconvoluted from the physics of soft, bulk event-by-event flow observables using event-shape engineering techniques.

Validation of PI-RADS v.2 for prostate cancer diagnosis with MRI at 3T using an external phased-array coil.

PURPOSE: To date, few studies have validated the Prostate Imaging Reporting and Data System Version 2 (PI-RADS v. 2) for the diagnosis of prostate cancer. Our aim was to validate PI-RADS v.2 using 3 Tesla (T) MRI. MATERIALS AND METHODS: This is a retrospective study of 54 consecutive patients who underwent 3T MRI with a body-array coil for diagnostic confirmation of prostate cancer or cancer staging between June 2013 and June 2015. Sensitivity, specificity, and agreement were calculated based on a criterion of PI-RADS score = 3. Inter-examiner agreement was determined by the weighted kappa statistic. RESULTS: Histological findings were positive for cancer in 33 patients and negative in 21 patients. Considering a PI-RADS score of 3 as positive for cancer, the accuracy of each reader was 85.20% and 70.40%, respectively, and agreement coefficients were κ = 0.69 and κ = 0.35. Considering PI-RADS 3 as absence of cancer, the accuracy of each reader was 77.80% and 77.80%, respectively, and agreement was κ = 0.55 and κ = 0.54. Inter-reader agreement was moderate/good (weighted κ = 0.53; 95% confidence interval: 0.39-0.66; P = 0.038). CONCLUSION: High accuracy was obtained for the diagnosis of prostate cancer using 3T MRI with a body coil and the PI-RADS v.2 score. J. Magn. Reson. Imaging 2016;44:1354-1359.

Suppression of Baryon Diffusion and Transport in a Baryon Rich Strongly Coupled Quark-Gluon Plasma.

Five dimensional black hole solutions that describe the QCD crossover transition seen in (2+1)-flavor lattice QCD calculations at zero and nonzero baryon densities are used to obtain predictions for the baryon susceptibility, baryon conductivity, baryon diffusion constant, and thermal conductivity of the strongly coupled quark-gluon plasma in the range of temperatures 130 MeV≤T≤300 MeV and baryon chemical potentials 0≤µ(B)≤400 MeV. Diffusive transport is predicted to be suppressed in this region of the QCD phase diagram, which is consistent with the existence of a critical end point at larger baryon densities. We also calculate the fourth-order baryon susceptibility at zero baryon chemical potential and find quantitative agreement with recent lattice results. The baryon transport coefficients computed in this Letter can be readily implemented in state-of-the-art hydrodynamic codes used to investigate the dense QGP currently produced at RHIC's low energy beam scan.

New exact solution of the relativistic Boltzmann equation and its hydrodynamic limit.

We present an exact solution of the relativistic Boltzmann equation for a system undergoing boost-invariant longitudinal and azimuthally symmetric transverse flow ("Gubser flow"). The resulting exact nonequilibrium dynamics is compared to first and second order relativistic hydrodynamic approximations for various shear viscosity to entropy density ratios. This novel solution can be used to test the validity and accuracy of different hydrodynamic approximations in conditions similar to those generated in relativistic heavy-ion collisions.

Increased tissue factor expression is an independent predictor of mortality in clear cell carcinoma of the kidney.

PURPOSE: Increased expression of tissue factor (TF), a primary initiator of the extrinsic coagulation pathway, has been associated with a worse prognosis in a variety of solid tumors. We report for the first time the correlation of the immunohistochemical expression of tissue factor with clinical and pathological outcomes in clear cell carcinomas of the kidney. MATERIALS AND METHODS: immunohistochemical expression of tissue factor was evaluated in 58 paraffin-embedded samples of clear cell carcinomas of the kidney treated at the same university hospital, that was correlated with clinical and pathological variables and with overall survival. RESULTS: high intensity tissue factor expression (TF area > 10 µ m2) was observed in 22.4% of the tumors (13 patients), and was an important predictor of overall mortality, both in univariate and multivariate analysis (p < 0.05). Median overall survival for both groups was 66 months; 78.2 months for patients in the group of lower TF expression and 27.5 months for patients in the group of higher TF expression (log rank p < 0.001). The hazard ratio for mortality was 9.7 (CI 3.7-25.6) for tumors with increased TF expression. CONCLUSIONS: Increased immunohistochemical expression of TF was an important independent predictor of mortality in a contemporary cohort of patients with clear cell carcinoma of the kidney. Further studies are necessary to define the role of TF in clinical practice.

Universal flow-driven conical emission in ultrarelativistic heavy-ion collisions.

The double-peak structure observed in soft-hard hadron correlations is commonly interpreted as a signature for a Mach cone generated by a supersonic jet interacting with the hot and dense medium created in ultrarelativistic heavy-ion collisions. We show that it can also arise due to averaging over many jet events in a transversally expanding background. We find that the jet-induced away-side yield does not depend on the details of the energy-momentum deposition in the plasma, the jet velocity, or the system size. Our claim can be experimentally tested by comparing soft-hard correlations induced by heavy-flavor jets with those generated by light-flavor jets.

Thermal width of the upsilon at large 't Hooft coupling.

We use the anti-de Sitter/conformal field theory correspondence to show that the heavy quark (static) potential in a strongly coupled plasma develops an imaginary part at finite temperature. Thus, deeply bound heavy quarkonia states acquire a small nonzero thermal width when the 't Hooft coupling lambda = g2N(c) >> 1 and the number of colors N(c) --> infinity. In the dual gravity description, this imaginary contribution comes from thermal fluctuations around the bottom of the classical sagging string in the bulk that connects the heavy quarks located at the boundary. We predict a strong suppression of Upsilon's in heavy-ion collisions and discuss how this may be used to estimate the initial temperature.

Transport coefficients of hadronic matter near Tc.

A hadron resonance gas model including all known particles and resonances with masses m < 2 GeV and an exponentially rising density of Hagedorn states for m > 2 GeV is used to obtain an upper bound on the shear viscosity to entropy density ratio, eta/s approximately 1/(4pi), of hadronic matter near Tc. We found a large trace anomaly and small speed of sound near Tc, which agree well with recent lattice calculations. We comment on the bulk viscosity to entropy density ratio close to Tc.

O papel da urodinâmica na avaliação da incontinência urinária em mulher pré tratamento cirúrgico / The role of presurgical urodynamic assessment in the treatment of stress urinary incontinence in women

Objetivos: Revisar o papel da avaliação urodinâmica pré tratamento cirurgico de incontinência urinária aos esforços (IUE) em mulheres. Métodos: Foi realizada revisão bibliográfica em maio de 2018 sobre estudo urodinâmico e incontinência urinária em mulheres nas bases de dados PubMed e Lilacs, utilizando como palavras-chaves na busca os termos urodynamics, women e urology, adotando como critérios de inclusão: data de publicação igual ou maior a janeiro/2013 (com exceção de um trabalho que foi incluído devido a relevância clínica no assunto); trabalhos redigidos em língua inglesa ou portuguesa; acesso livre ao texto integral e abordagem da avaliação urodinâmica (AUD) em mulheres com IUE. Os critérios de exclusão foram incontinência urinária (IU) em pacientes do sexo masculino e crianças, além de comorbidades neurológicas. Resultados: O estudo urodinâmico é um exame que avalia a função do complexo uretro-vesical nas fases de enchimento e esvaziamento do ciclo miccional. A AUD auxilia a detectar e a diagnosticar com maior precisão as disfunções do trato urinário inferior (DTUI) com base em sua fisiopatologia, podendo assim participar da tomada de decisão terapêutica. Conclusões: O estudo urodinâmico pré-operatório deve ser reservado para casos selecionados, como na incontinência urinária complicada, nos prolapsos genitais e disfunções neurológicas. Portanto, não deve ser solicitado de rotina em todas as pacientes com incontinência urinária.

Aims: to review the role of preoperative urodynamic assessment in the treatment of stress urinary incontinence in women. Methods: Bibliographic review was performed in May 2018 on urodynamic and stress urinary incontinence in the PubMed and Lilacs databases, using the key terms urodynamics, women and urology. The inclusion criteria used as reference were: publication date equal to or greater than January 2013 (except for two articles, which were included for clinical relevance in the subject); papers written in English or Portuguese; free access to the full text and approach to Urodynamic Assessment (AUD) in women with IUE. The exclusion criteria were IU in male patients, children and neurological comorbidities. Results: The urodynamic study is a test that evaluates the function of the urethral and bladder complex at the phases of filling and emptying of the voiding cycle. The AUD helps to detect and diagnose more accurately the lower urinary tract dysfunctions (DTUI) based on your pathophysiology, and thus participate in the therapeutic decision making. Conclusions: The preoperative urodynamic study should be reserved for selected cases, such as complicated urinary incontinence, genital prolapses and neurological dysfunctions. Therefore, it should not be done routinely in all patients with urinary incontinence.

Serum tissue factor as a biomarker for renal clear cell carcinoma

ABSTRACT Purpose to determine the usefulness of serum TF as a potential marker for patients with clear cell RCC. Materials and Methods prospective study of 30 patients with clear cell RCC submitted to nephrectomy and 16 controls without clear cell RCC treated surgically for other conditions. TF is a endothelium marker that was correlated with worse prognosis in a variety of solid tumors including RCC. Serum TF was collected before surgery at the operating room and in the postoperative setting after at least four weeks. Serum samples were analyzed with a commercial ELISA kit for human TF (R&D Systems®). Results Mean preoperative serum TF levels in clear cell RCC patients and in controls were 66.8 pg/dL and 28.4 pg/dL, respectively (p<0.001). Mean postoperative serum TF levels in clear cell RCC patients were 26.3 pg/dL. In all patients with clear cell RCC postoperative serum levels of TF were lower, with a mean reduction of 41.6 pg/dL in the postoperative setting (p<0.001). Linear regression revealed that tumor size was correlated with the postoperative reduction of serum TF levels (p=0.037). Conclusions We have shown a 3-fold reduction in the median preoperative serum levels of TF in patients with clear cell RCC after surgery. We have also shown a difference of the same magnitude in the serum levels of TF compared with those of a control group of patients with benign diseases. TF appears to be a useful serum marker for the presence of clear cell RCC. Further studies are needed to validate these findings.