Detalhe da pesquisa
1.
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity.
Nat Immunol
; 23(4): 568-580, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35314846
2.
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.
Cell
; 178(4): 949-963.e18, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31353221
3.
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study.
Am J Hematol
; 98(3): 449-463, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594167
4.
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.
Xenobiotica
; 49(9): 1063-1077, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257601
5.
Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker.
Chemistry
; 24(19): 4830-4834, 2018 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29493023
6.
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J
; 31(17): 3513-23, 2012 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22773185
7.
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(17): 4875-85, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23899614
8.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett
; 23(20): 5488-97, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24021463
9.
Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
Nat Commun
; 13(1): 2057, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35440108
10.
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Cancer Discov
; 12(1): 204-219, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34544753
11.
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
J Med Chem
; 64(16): 11841-11856, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34251202
12.
VCAM-1 Density and Tumor Perfusion Predict T-cell Infiltration and Treatment Response in Preclinical Models.
Neoplasia
; 21(10): 1036-1050, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31521051
13.
Monitoring and Targeting Anti-VEGF Induced Hypoxia within the Viable Tumor by 19F-MRI and Multispectral Analysis.
Neoplasia
; 19(11): 950-959, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28987998
14.
Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models.
Mol Cancer Ther
; 15(5): 1132-44, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26939706
15.
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.
J Med Chem
; 59(18): 8345-68, 2016 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27541271
16.
Prediction of drug distribution in subcutaneous xenografts of human tumor cell lines and healthy tissues in mouse: application of the tissue composition-based model to antineoplastic drugs.
J Pharm Sci
; 104(4): 1508-21, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25615572
17.
Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.
Toxicol Sci
; 144(1): 163-72, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25505128
18.
Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
J Med Chem
; 57(3): 770-92, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405419
19.
Mapping in vivo tumor oxygenation within viable tumor by 19F-MRI and multispectral analysis.
Neoplasia
; 15(11): 1241-50, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24339736
20.
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.
Neoplasia
; 15(12): 1314-29, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24403854