Relationship between anemia and oral cancer: a case-control study.

The aim of this study was to investigate the occurrence, type and severity of anemia at the time of diagnosis of oral cancer, and its potential association with the degree of tumor cell differentiation. This case-control study used 366 medical records of patients treated at two referral centers for oral cancer diagnosis, specifically: cases (n=70) with a histopathological diagnosis of oral squamous cell carcinoma (OSCC) of the oral cavity, and controls (n=296) with benign oral lesions. Sociodemographic, behavioral, and clinical variables of both groups, as well as complete blood count values, were analyzed by descriptive statistics and crude/adjusted logistic regression. Anemia was detected in 15.7% of the cases and 11.8% of the controls. The presence of anemia had an OR=1.64 (odds ratio) (95%CI 0.54-5.00) for OSCC, with no significantly statistical association. Normocytic anemia was the most prevalent form of anemia when oral cancer was diagnosed (91.4% of the controls and 72.7% of the cases), and moderate to severely low hemoglobin levels were associated with OSCC diagnosis (OR 6.49; 95%CI 1.18-35.24), albeit data on hematological examinations were missing.

Relationship between anemia and oral cancer: a case-control study

Abstract The aim of this study was to investigate the occurrence, type and severity of anemia at the time of diagnosis of oral cancer, and its potential association with the degree of tumor cell differentiation. This case-control study used 366 medical records of patients treated at two referral centers for oral cancer diagnosis, specifically: cases (n=70) with a histopathological diagnosis of oral squamous cell carcinoma (OSCC) of the oral cavity, and controls (n=296) with benign oral lesions. Sociodemographic, behavioral, and clinical variables of both groups, as well as complete blood count values, were analyzed by descriptive statistics and crude/adjusted logistic regression. Anemia was detected in 15.7% of the cases and 11.8% of the controls. The presence of anemia had an OR=1.64 (odds ratio) (95%CI 0.54-5.00) for OSCC, with no significantly statistical association. Normocytic anemia was the most prevalent form of anemia when oral cancer was diagnosed (91.4% of the controls and 72.7% of the cases), and moderate to severely low hemoglobin levels were associated with OSCC diagnosis (OR 6.49; 95%CI 1.18-35.24), albeit data on hematological examinations were missing.

Oral manifestations in pediatric patients receiving chemotherapy for leukemia / Manifestações bucais em pacientes pediátricos submetidos a quimioterapia para leucemia

Cross-sectional study of 36 children with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). Intraoral examination and oral hygiene assessment were performed in all patients. Information was also obtained from interviews of patients' mothers and a review of medical records. Results: The sample was largely composed of boys (58.3%), ages 5­9 years. The most commonly used chemotherapy regimen was the BFM-95 protocol. Most children (83.3%) had a record of some oral manifestation during treatment. On intraoral examination, 17 children (50%) were found to have at least one oral manifestation. The most frequent manifestation was also mucositis (26.5%), followed by gingival bleeding (23.4%). Lower maternal educational level was associated with increased frequency of mucositis, as were induction chemotherapy and maintenance chemotherapy after relapse. Conclusions: Oral abnormalities were common in children receiving chemotherapy and mucositis was the most prevalent manifestation. Oral lesions were associated with the induction phase of chemotherapy. Mucositis was not associated with oral health status.

Estudo transversal de 36 crianças com leucemia linfoblástica aguda (LLA) ou leucemia mieloide aguda (LMA). Exame intraoral e avaliação de higiene bucal foram realizados em todos os pacientes. A informação também foi obtida a partir de entrevistas com as mães dos pacientes e uma revisão dos registros médicos. Resultados: A amostra foi composta em grande parte dos meninos (58,3%), com idades entre 5-9 anos. O regime de quimioterapia mais comumente utilizado foi o protocolo BFM-95. A maioria das crianças (83,3%) teve um registro de alguma manifestação oral durante o tratamento. Ao exame intraoral, 17 crianças (50%) apresentaram ter pelo menos uma manifestação oral. A manifestação mais frequente foi mucosite (26,5%), seguido por sangramento gengival (23,4%). Baixa escolaridade materna foi associada com aumento da frequência de mucosite, assim como a quimioterapia de indução e quimioterapia de manutenção após recaída. Conclusões: Anormalidades orais são comuns em crianças que receberam quimioterapia e mucosite foi a manifestação mais prevalente. As lesões foram associados com a fase de indução da quimioterapia. Mucosite não foi associado com o estado de saúde oral.

Tratamento da queilite actínica através da técnica cirúrgica da vermelhectomia / Treatment of actinic cheilitis by surgical vermilionectomy

A queilite actínica é uma lesão cancerizável que acomete principalmente o lábio inferior, cujo fator etiológico está relacionado à exposição crônica aos raios ultravioletas. Possui uma predileção aumentada por indivíduos que apresentam atividade laboral com intensa exposição ao sol. Clinicamente, observam-se áreas maculares brancas ou avermelhadas ou lesões em forma de placas esbranquiçadas resultantes da hiperceratinização do epitélio do lábio, a qual pode progredir para a perda do limite entre a pele, vermelhão do lábio e a mucosa. Essas lesões são geralmente assintomáticas e podem progredir para áreas erosivas e/ou ulceradas. Dentre as diversas formas de tratamento, há a vermelhectomia, que consiste num procedimento cirúrgico para a remoção parcial ou total do vermelhão do lábio, apresentando baixo custo e permitindo a disponibilidade de material para exame anatomopatológico. O objetivo desse trabalho é relatar a técnica de vermelhectomia no tratamento de um paciente com diagnóstico de queilite actínica...

Actinic cheilitis is a potentially premalignant condition that is primarily found on the lower lip. Etiology is related to chronic exposure to ultraviolet light and the condition exhibits a strong predilection for people whose work involves intense exposure to the sun. Clinically observable signs include white or reddened areas of maculation or whitish plaques caused by hyperkeratinization of the lip epithelium, which can progress to a point at which the demarcation between the skin, vermillion border of the lip and the mucosa is lost. These lesions are generally asymptomatic but may progress to form areas of erosion and/or ulceration. There are a number of treatments available, one of which, vermilionectomy, is a surgical procedure in which the vermillion border of the lip is partially or totally removed and which, in addition to being inexpensive, offers the advantage of providing material for pathological analysis. The objective of this study is to describe the vermilionectomy technique as used to treat a patient diagnosed with actinic cheilitis...