Detalhe da pesquisa
1.
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc Natl Acad Sci U S A
; 116(14): 7015-7020, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30894487
2.
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc Natl Acad Sci U S A
; 116(19): 9318-9323, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962368
3.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
4.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
5.
Application of a novel regulatable Cre recombinase system to define the role of liver and gut metabolism in drug oral bioavailability.
Biochem J
; 465(3): 479-88, 2015 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25377919
6.
The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.
Antimicrob Agents Chemother
; 57(10): 4699-706, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856774
7.
Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors.
J Med Chem
; 66(15): 10413-10431, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506194
8.
Identification and development of a series of disubstituted piperazines for the treatment of Chagas disease.
Eur J Med Chem
; 238: 114421, 2022 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35594652
9.
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.
Nat Commun
; 13(1): 5992, 2022 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36220877
10.
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 64(9): 5905-5930, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33904304
11.
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity.
J Med Chem
; 63(17): 9523-9539, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32663005
12.
Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis.
RSC Med Chem
; 11(10): 1168-1177, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479621
13.
Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1).
ACS Med Chem Lett
; 10(3): 341-347, 2019 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30891137
14.
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
ChemMedChem
; 14(14): 1329-1335, 2019 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31188540
15.
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 62(3): 1180-1202, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30570265
16.
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.
ACS Infect Dis
; 4(6): 954-969, 2018 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29522317
17.
Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.
ACS Infect Dis
; 3(10): 718-727, 2017 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28967262
18.
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
J Med Chem
; 60(17): 7284-7299, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844141
19.
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.
ACS Infect Dis
; 3(1): 18-33, 2017 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27704782
20.
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis.
Elife
; 52016 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27215734