Detalhe da pesquisa
1.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
2.
Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors.
Chemistry
; 29(20): e202203958, 2023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36617500
3.
The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa.
Proc Natl Acad Sci U S A
; 116(21): 10198-10200, 2019 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085658
4.
Human nuclear hormone receptor activity contributes to malaria parasite liver stage development.
Cell Chem Biol
; 30(5): 486-498.e7, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37172592
5.
Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.
Elife
; 122023 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37737220
6.
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.
Sci Transl Med
; 15(686): eadc9249, 2023 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36888694
7.
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.
Br J Pharmacol
; 180(15): 1899-1929, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37197802
8.
Semi-Synthetic Analogues of Cryptolepine as a Potential Source of Sustainable Drugs for the Treatment of Malaria, Human African Trypanosomiasis, and Cancer.
Front Pharmacol
; 13: 875647, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35600849
9.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Sci Transl Med
; 14(667): eabo7219, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260689
10.
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Cell Chem Biol
; 29(2): 191-201.e8, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34348113
11.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Cell Chem Biol
; 29(5): 824-839.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233174
12.
Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.
Commun Biol
; 5(1): 128, 2022 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35149760
13.
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.
Science
; 376(6597): 1074-1079, 2022 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653481
14.
PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum.
ACS Infect Dis
; 7(4): 811-825, 2021 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33715347
15.
MalDA, Accelerating Malaria Drug Discovery.
Trends Parasitol
; 37(6): 493-507, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33648890
16.
Prioritization of Molecular Targets for Antimalarial Drug Discovery.
ACS Infect Dis
; 7(10): 2764-2776, 2021 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34523908
17.
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.
Nat Commun
; 12(1): 269, 2021 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33431834
18.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
19.
Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty.
Pharmaceuticals (Basel)
; 13(2)2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32028743
20.
Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.
Cell Chem Biol
; 27(2): 158-171.e3, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31813848