Sex-disease dimorphism underpins enhanced motion sickness susceptibility in primary adrenal insufficiency: a cross-sectional observational study.

Environmental motion can induce physiological stress and trigger motion sickness. In these situations, lower-than-normal levels of adrenocorticotropic hormone (ACTH) have been linked with increased susceptibility to motion sickness in healthy individuals. However, whether patients with primary adrenal insufficiency, who typically have altered ACTH levels compared to the normal population, exhibit alterations in sickness susceptibility remains unknown. To address this, we recruited 78 patients with primary adrenal insufficiency and compared changes in the motion sickness susceptibility scores from 10 years prior to diagnosis (i.e. retrospective sickness rating) with the current sickness measures (post-diagnosis), using the validated motion sickness susceptibility questionnaire (MSSQ). Group analysis revealed that motion sickness susceptibility pre-diagnosis did not differ between controls and patients. We observed that following treatment, current measures of motion sickness were significantly increased in patients and subsequent analysis revealed that this increase was primarily in female patients with primary adrenal insufficiency. These observations corroborate the role of stress hormones in modulating sickness susceptibility and support the notion of a sexually dimorphic adrenal cortex as we only observed selective enhancement in females. A potential mechanism to account for our novel observation remains obscure, but we speculate that it may reflect a complex sex-disease-drug interaction.

Individual differences and the transposed letter effect during reading.

When a preview contains substituted letters (SL; markey) word identification is more disrupted for a target word (monkey), compared to when the preview contains transposed letters (TL; mnokey). The transposed letter effect demonstrates that letter positions are encoded more flexibly than letter identities, and is a robust finding in adults. However, letter position encoding has been shown to gradually become more flexible as reading skills develop. It is unclear whether letter position encoding flexibility reaches maturation in skilled adult readers, or whether some differences in the magnitude of the TL effect remain in relation to individual differences in cognitive skills. We examined 100 skilled adult readers who read sentences containing a correct, TL or SL preview. Previews were replaced by the correct target word when the reader's gaze triggered an invisible boundary. Cognitive skills were assessed and grouped based on overlapping variance via Principal Components Analysis (PCA) and subsequently used to predict eye movement measures for each condition. Consistent with previous literature, adult readers were found to generally encode letter position more flexibly than letter identity. Very few differences were found in the magnitude of TL effects between adults based on individual differences in cognitive skills. The flexibility of letter position encoding appears to reach maturation (or near maturation) in skilled adult readers.

No evidence for high inflexible precision of prediction errors in autism during lexical processing.

Research has shown that information processing differences associated with autism could impact on language and literacy development. This study tested an approach to autistic cognition that suggests learning occurs via prediction errors, and autistic people have very precise and inflexible predictions that result in more sensitivity to meaningless signal errors than non-autistic readers. We used this theoretical background to investigate whether differences in prediction coding influence how orthographic (Experiment 1) and semantic information (Experiment 2) is processed by autistic readers. Experiment 1 used a lexical decision task to test whether letter position information was processed less flexibly by autistic than non-autistic readers. Three types of letter strings: words, transposed letter and substituted letters nonwords were presented. Experiment 2 used a semantic relatedness task to test whether autistic readers processed words with high and low semantic diversity differently to non-autistic readers. Results showed similar transposed letter and semantic diversity effects for all readers; indicating that orthographic and semantic information are processed similarly by autistic and non-autistic readers; and therefore, differences in prediction coding were not evident for these lexical processing tasks.

Programme of the 21st European Conference on Eye Movements.

About ECEM ECEM was initiated by Rudolf Groner (Bern), Dieter Heller (Bayreuth at the time) and Henk Breimer (Tilburg) in the 198 to provide a forum for an interdisciplinary group of scientists interested in eye movements. Since the inaugural meeting in Bern, the conference has been held every two years in different venues across Europe until 2021, when it was planned to take place in Leicester but was cancelled due to the COVID pandemic. It was decided to hold the meeting in Leicester in August 2022 instead, and as an in person meeting rather than an online or hybrid event. Incidentally, the present meeting is the third time the conference has come to the English East Midlands, now in Leicester following previous meetings in the neighbouring cities of Derby and Nottingham. The sites of previous ECEMs and webpages can be found here..

Book of Abstracts of the 21th European Conference on Eye Movements in Leicester 2022.

Contents Keynotes: Iain Gilchrist: Integrative Active Vision p 5 Ziad Hafed: A Vision for orienting in Primate Oculomotor Control Circuitry p 6 Fatema Ghasia: Miniscule Eye Movements Play a Major Role in Binocular Vision Disorders p.7 Miriam Spering: Eye Movements as a Window into Human Decision-Making p.8 Monica S. Castelhano: Explorations of how Scene Context and Previous Experience Dynamically Influence Attention and Eye Movement Guidance p.9   Symposia: Eye Tracking and the Visual Arts p.19 Eye Movements during Text Processing and Multiline Reading p.23 Unstable Fixation and Nystagmus with a Focus on the Next Generation of Researchers p.84 Eye Movements as a measure of Higher-Level Text Processing p.97 Eye Movements in Memory Processes Between Working Memory and Long-Term Memory p.178 Symposium to Honour Alexander Pollatsek's Legacy to Eye Movement Research p.204   Talks: Reading p.30 Parafoveal Processing p.36 Cinical and Applied p.39 Visual Search p.92 Eye Movement Control in Reading I & II p.104 & 116 & 225 Reading Development p.110 Decision-Making p.122 Eye-tracking Methods p.128 Real World and Virtual Reality p.134 Chinese Reading p.185 Special Populations p.191 Visuo-motor p.195 Bilingual Reading p.201 & 217 Reading Comprehension p.219 Pupillometry p.235   Poster sessions: Attention p.44 & 139 Cognition p. 49 Visuo-Motor p.62 Memory p.145 Methods p.150 Reading p. 57 & 155 Real World p.169 Social Cognition p.173.

Eye movements of children and adults reading in three different orthographies.

In this study, we investigated developmental aspects of eye movements during reading of three languages (English, German, and Finnish) that vary widely in their orthographic complexity and predictability. Grapheme-phoneme correspondence rules are rather complex in English and German but relatively simple in Finnish. Despite their differences in complexity, the rules in German and Finnish are highly predictable, whereas English has many exceptions. Comparing eye movement development in these three languages allows us to investigate whether orthographic complexity and predictability have separate effects on eye movement development. Three groups of children, matched on years of reading instruction, along with a group of proficient adult readers in each language were tested. All participants read stimulus materials that were carefully translated and back-translated across all three languages. The length and frequency of 48 target words were manipulated experimentally within the stimulus set. For children, word length effects were stronger in Finnish and German than in English. In addition, in English effects of word frequency were weaker and only present for short words. Generally, English children showed a qualitatively different reading pattern, while German and Finnish children's reading behavior was rather similar. These results indicate that the predictability of an orthographic system is more important than its complexity for children's reading development. Adults' reading behavior, in contrast, was remarkably similar across languages. Our results demonstrate that eye movements are sensitive to language-specific features in children's reading, but become more homogenous as reading skill matures. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Are older adults more risky readers? Evidence from meta-analysis.

According to an influential account of aging effects on reading, older adults (65+ years) employ a more "risky" reading strategy compared to young adults (18-30 years), in which they attempt to compensate for slower processing by using lexical and contextual knowledge to guess upcoming (i.e., parafoveal) words more often. Consequently, while older adults may read more slowly, they might also skip words more often (by moving their gaze past words without fixating them), especially when these are of higher lexical frequency or more predictable from context. However, this characterization of aging effects on reading has been challenged recently following several failures to replicate key aspects of the risky reading hypothesis, as well as evidence that key effects predicted by the hypothesis are not observed in Chinese reading. To resolve this controversy, we conducted a meta-analysis of 102 eye movement experiments comparing the reading performance of young and older adults. We focused on the reading of sentences displayed normally (i.e., without unusual formatting or structures, or use of gaze-contingent display-change techniques), conducted using an alphabetic script or Chinese, and including experiments manipulating the frequency or predictability of a specific target word. Meta-analysis confirmed that slower reading by older compared to younger adults is accompanied by increased word-skipping, although only for alphabetic scripts. Meta-analysis additionally showed that word-skipping probabilities are unaffected by age differences in word frequency or predictability effects, casting doubt on a central component of the risky reading hypothesis. We consider implications for future research on aging effects on reading. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The influence of children's reading ability on initial letter position encoding during a reading-like task.

Previous studies exploring the cost of reading sentences with words that have two transposed letters in adults showed that initial letter transpositions caused the most disruption to reading, indicating the important role that initial letters play in lexical identification (e.g., Rayner et al., 2006). Regarding children, it is not clear whether differences in reading ability would affect how they encode letter position information as they attempt to identify misspelled words in a reading-like task. The aim of this experiment was to explore how initial-letter position information is encoded by children compared to adults when reading misspelled words, containing transpositions, during a reading-like task. Four different conditions were used: control (words were correctly spelled), TL12 (letters in first and second positions were transposed), TL13 (letters in first and third positions were transposed), and TL23 (letters in second and third positions were transposed). Results showed that TL13 condition caused the most disruption, whereas TL23 caused the least disruption to reading of misspelled words. Although disruption for the TL13 condition was quite rapid in adults, the immediacy of disruption was less so for the TL23 and TL12 conditions. For children, effects of transposition also occurred quite rapidly but were longer lasting. The time course was particularly extended for the less skilled relative to the more skilled child readers. This pattern of effects suggests that both adults and children with higher, relative to lower, reading ability encode internal letter position information more flexibly to identify misspelled words, with transposed letters, during a reading-like task. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The influence of item-level contextual history on lexical and semantic judgments by children and adults.

Semantic diversity quantifies the similarity in the content of contexts a word has been experienced in. Four experiments investigated its effect on lexical and semantic judgments in 9- to 10-year-olds and adults. In Experiment 1, a cross-modal semantic judgment task, participants decided whether a visually presented word matched an audio definition. Both groups were slower to respond to words high in semantic diversity, and this effect was modulated by task demands. Experiment 2 used the same items but in a lexical-decision task. Children were faster to respond to words high in diversity but there was no effect in adults, failing to replicate previous work. Experiment 3 examined possible reasons for this, and Experiment 4 tested the effect of semantic diversity on lexical decision via secondary analysis of 2 large megastudies. Overall, the facilitative effect of semantic diversity on lexical decision was robust. Our findings show that contextual experience influences subsequent lexical processing, consistent with context inducing semantic representations that reflect continuities and gradations in meaning. These gradations are captured by semantic diversity, and in turn, this interacts with task demands to influence behavioral performance. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Effects of Normative Aging on Eye Movements during Reading.

Substantial progress has been made in understanding the mostly detrimental effects of normative aging on eye movements during reading. This article provides a review of research on aging effects on eye movements during reading for different writing systems (i.e., alphabetic systems like English compared to non-alphabetic systems like Chinese), focused on appraising the importance of visual and cognitive factors, considering key methodological issues, and identifying vital questions that need to be addressed and topics for further investigation.

Learning Words Via Reading: Contextual Diversity, Spacing, and Retrieval Effects in Adults.

We examined whether variations in contextual diversity, spacing, and retrieval practice influenced how well adults learned new words from reading experience. Eye movements were recorded as adults read novel words embedded in sentences. In the learning phase, unfamiliar words were presented either in the same sentence repeated four times (same context) or in four different sentences (diverse context). Spacing was manipulated by presenting the sentences under distributed or non-distributed practice. After learning, half of the participants were asked to retrieve the new words, and half had an extra exposure to the new words. Although words experienced in diverse contexts were acquired more slowly during learning, they enjoyed a greater benefit of learning at immediate posttest. Distributed practice also slowed learning, but no benefit was observed at posttest. Although participants who had an extra exposure showed the greatest learning benefit overall, learning also benefited from retrieval opportunity, when words were experienced in diverse contexts. These findings demonstrate that variation in the content and structure of the learning environment impacts on word learning via reading.

Parafoveal preprocessing of word initial trigrams during reading in adults and children.

Although previous research has shown that letter position information for the first letter of a parafoveal word is encoded less flexibly than internal word beginning letters (Johnson, Perea & Rayner, 2007; White et al., 2008), it is not clear how positional encoding operates over the initial trigram in English. This experiment explored the preprocessing of letter identity and position information of a parafoveal word's initial trigram by adults and children using the boundary paradigm during normal sentence reading. Seven previews were generated: Identity (captain); transposed letter and substituted letter nonwords in Positions 1 and 2 (acptain-imptain); 1 and 3 (pactain-gartain), and 2 and 3 (cpatain-cgotain). Results showed a transposed letter effect (TLE) in Position 13 for gaze duration in the pretarget word; and TLE in Positions 12 and 23 but not in Position 13 in the target word for both adults and children. These findings suggest that children, similar to adults, extract letter identity and position information flexibly using a spatial coding mechanism; supporting isolated word recognition models such as SOLAR (Davis, 1999, 2010) and SERIOL (Whitney, 2001) models.

An inhibitory influence of transposed-letter neighbors on eye movements during reading.

Previous research has shown that prior exposure to a word's substitution neighbor earlier in the same sentence can disrupt processing of that word, indicating that interword lexical priming occurs naturally during reading, due to the competition between lexical candidates during word identification. Through the present research, we extended these findings by investigating the effects of prior exposure to a word's transposed-letter neighbor (TLN) earlier in a sentence. TLNs are constituted from the same letters, but in different orders. The findings revealed an inhibitory TLN effect, with longer total reading times for target words, and increased regressions to prime and target words, when the target followed a TLN rather than a control word. These findings indicate that prior exposure to a TLN can disrupt word identification during reading. We suggest that this is caused by a failure of word identification, due to the initial misidentification of the target word (potentially as its TLN) triggering postlexical checking.

Beyond decoding: phonological processing during silent reading in beginning readers.

In this experiment, the extent to which beginning readers process phonology during lexical identification in silent sentence reading was investigated. The eye movements of children aged seven to nine years and adults were recorded as they read sentences containing either a correctly spelled target word (e.g., girl), a pseudohomophone (e.g., gerl), or a spelling control (e.g., garl). Both children and adults showed a benefit from the valid phonology of the pseudohomophone, compared to the spelling control during reading. This indicates that children as young as seven years old exhibit relatively skilled phonological processing during reading, despite having moved past the use of overt phonological decoding strategies. In addition, in comparison to adults, children's lexical processing was more disrupted by the presence of spelling errors, suggesting a developmental change in the relative dependence upon phonological and orthographic processing in lexical identification during silent sentence reading.

El papel de la sílaba en la codificación posicional de las representaciones ortográficas / The role of the syllable in positional information coding in orthographic representations

El objetivo de este trabajo consiste en estudiar si la posición de las letras se codifica de una forma absoluta o relativa, y en particular, conocer el papel que la sílaba juega en la codificación de la información posicional dentro de las representaciones ortográficas. Para ello, empleamos dos experimentos con una tarea de solución de anagramas. En dicha tarea, se presenta un anagrama (CSIAGTO) y el participante tiene que descubrir la palabra que se forma ordenando las letras internas del anagrama (CASTIGO). Los resultados del Experimento 1 muestran un efecto de la presencia de bigramas adyacentes: los anagramas que mantienen un bigrama en una posición adyacente (CTGASIO) son resueltos con más frecuencia que aquellos con todas las letras internas desordenadas (CSIAGTO), lo que sugiere que para reconstruir una secuencia altamente distorsionada, es importante conocer la posición relativa de una letra con respecto a otra. En el Experimento 2, manipulamos la naturaleza silábica o subsilábica del bigrama para estudiar si el efecto de bigrama puede reducirse a un efecto silábico o puede estar modulado por el estatus subléxico (silábico o subsilábico) del bigrama. Los resultados obtenidos muestran un efecto silábico. Finalmente, examinamos las implicaciones de estos resultados para los modelos actuales de reconocimiento visual de palabras (AU)

The main aims of this study are: I) to examine whether the positional information is coded in absolute or relative terms in orthographic representations, and II) to explore the role of syllabic units in this process. To that end, we will use a new technique: the Anagram Solution Task (AST). In an AST, an anagram is presented (e.g., CSIAGTO) and the participant has to mentally rearrange the inner letters of the word (CASTIGO -punishment, penalty). In Experiment 1, the results showed a bigram effect: the anagrams that maintained a bigram in an adjacent position (CTGASIO) were solved with higher accuracy than those anagrams that had all inner letters disordered (CSIAGTO). That is, relative position is more effective than absolute position to reconstruct a highly disordered anagram. In Experiment 2, we examined whether or not this bigram effect had a syllable nature by manipulating syllabic bigram structure. Results showed a syllabic effect. Taken together, the data have implications for the current models of visual-word recognition (AU)