Detalhe da pesquisa
1.
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent.
Bioorg Med Chem
; 28(23): 115797, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33075682
2.
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem
; 22(7): 2280-93, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24588963
3.
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 23(2): 537-42, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23218712
4.
PLAG alleviates cisplatin-induced cachexia in lung cancer implanted mice.
Transl Oncol
; 20: 101398, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35339890
5.
Mitigation of Hematopoietic Syndrome of Acute Radiation Syndrome by 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) is Associated with Regulation of Systemic Inflammation in a Murine Model of Total-Body Irradiation.
Radiat Res
; 196(1): 55-65, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33914879
6.
Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies.
Bioorg Med Chem Lett
; 20(8): 2586-90, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20303263
7.
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
Bioorg Med Chem Lett
; 20(2): 636-9, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19969455
8.
Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors.
Bioorg Med Chem
; 17(11): 3857-65, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19410464
9.
Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A.
Methods Enzymol
; 431: 303-24, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17923240
10.
Compound 19e, a Novel Glucokinase Activator, Protects against Cytokine-Induced Beta-Cell Apoptosis in INS-1 Cells.
Front Pharmacol
; 8: 169, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28405188
11.
The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices.
Eur J Pharmacol
; 536(3): 262-8, 2006 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16600209
12.
Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM.
ACS Med Chem Lett
; 6(3): 296-301, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25815149
13.
Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.
J Med Chem
; 47(26): 6603-8, 2004 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15588095
14.
Pentadienylnitrobenzyl and Pentadienylnitropiperonyl Photochemically Removable Protecting Groups.
J Org Chem
; 64(14): 5042-5047, 1999 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34237832
15.
Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells.
Eur J Pharm Sci
; 51: 137-45, 2014 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24056026
16.
Identification of YH-GKA, a novel benzamide glucokinase activator as therapeutic candidate for type 2 diabetes mellitus.
Arch Pharm Res
; 35(12): 2029-33, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23263798
17.
Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters.
J Med Chem
; 51(14): 4115-21, 2008 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18578470
18.
Identification of novel orally available small molecule insulin mimetics.
J Pharmacol Exp Ther
; 323(2): 579-85, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17687071
19.
Design and synthesis of butynyloxyphenyl beta-sulfone piperidine hydroxamates as TACE inhibitors.
Bioorg Med Chem Lett
; 16(15): 3927-31, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16723229
20.
Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.
Bioorg Med Chem Lett
; 16(2): 457-60, 2006 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16274990