Anxiety and depression in reproductive age women with rheumatic diseases.

Women in reproductive age with rheumatic diseases (RD) are especially vulnerable for depression and anxiety which negatively impacts the pregnancy, birth, and RD. The purpose of this study is to describe the frequency of anxiety and depression symptoms employing the Hospital Anxiety and Depression Scale (HADS) in women in reproductive age. We conducted an observational, single-center, cross-sectional, and descriptive study in reproductive-age, non-pregnant women without a prior psychiatric diagnosis. Differences between disease groups, subscale results, and disease activity were analyzed with the Chi square, Mann-Whitney U test, or Kruskal-Wallis test. A total of 100 women were included. Mean age was 35.3 years (SD = 10.07). The most frequent diagnosis was rheumatoid arthritis (RA) with 48, followed by systemic lupus erythematosus (SLE) with 30. A total of 66 (66%) patients had an abnormal HADS score (probable or possible cases) in either subscale. More than 50% of RA patients had an abnormal HADS score. We found an association between RA disease activity groups and total HADS score (p = 0.003). Furthermore, we found a statically significant association between RA activity groups and HADS anxiety subscales group classification (p = 0.01). No differences between disease activity groups of SLE or other diseases and HADS classification or total score was found (p = 0.277). A high frequency of probable or possible cases of depression and anxiety were recognized in reproductive-age women with RD. A high RA disease activity was associated with a high total HADS score and an increased presence of anxiety symptoms.

Role of rheumatoid factor isotypes and anti-citrullinated peptide antibodies in the differential diagnosis of non-selected patients with inflammatory arthralgia.

BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by swelling, tenderness and destruction of synovial joints, leading to severe disability and premature mortality. The aim of the study was to determine the diagnostic accuracy of the 3 isotypes of rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA) and the combination of both, for the diagnosis of rheumatoid arthritis (RA) in non-selected patients with inflammatory arthralgia. METHODS: We include 129 patients with inflammatory Arthalgia from a third level reference Center of rheumatic diseases in Monterrey, México. Their samples were analyzed for RF isotypes (IgA, IgG, and IgM) by ELISA (EUROINMUN), using a cut-off of 20IU/ml, and for ACPA's 5IU/ml; a medical examination was performed to obtain the definitive diagnoses of the patients. Data analysis was carried out using ROC curves for the measurement of sensitivity, specificity, for diagnostic accuracy to verify if the use of 3 RF isotypes and ACPA had a better prediction for the diagnosis of RA than use only one isotype and the ACPA alone. RESULTS: The ROC showed a sensitivity and specificity of the different antibodies with different cut-off points, being the best for the IgM with 0.802 followed by ACPA, IgA and IgG with 0.771, 0.63, and 0.728 respectively without statistical difference, the sensitivity and specificity of the combination of the 4 antibodies were 81.4 and 73.66%. CONCLUSION: In non-selected patients with inflammatory arthralgia, the combination of ACPA and isotypes of RF did not demonstrate more sensibility and specificity than IgM isoform of rheumatoid factor measurement only. We recommend that in the clinical scenario of arthralgia, where the diagnoses are Lupus, Sjogren syndrome and Osteoarthritis, RF IgM isoform is used followed by ACPA.

Role of rheumatoid factor isotypes and anti-citrullinated peptide antibodies in the differential diagnosis of non-selected patients with inflammatory arthralgia / Rol de los isotipos del factor reumatoide y los anticuerpos anti-péptido cíclico citrulinado en el diagnóstico diferencial de pacientes no seleccionados con artralgia inflamatoria

Background/ObjectivesRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by swelling, tenderness and destruction of synovial joints, leading to severe disability and premature mortality. The aim of the study was to determine the diagnostic accuracy of the 3 isotypes of rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA) and the combination of both, for the diagnosis of rheumatoid arthritis (RA) in non-selected patients with inflammatory arthralgia.MethodsWe include 129 patients with inflammatory Arthalgia from a third level reference Center of rheumatic diseases in Monterrey, México. Their samples were analyzed for RF isotypes (IgA, IgG, and IgM) by ELISA (EUROINMUN), using a cut-off of 20IU/ml, and for ACPA's 5IU/ml; a medical examination was performed to obtain the definitive diagnoses of the patients. Data analysis was carried out using ROC curves for the measurement of sensitivity, specificity, for diagnostic accuracy to verify if the use of 3 RF isotypes and ACPA had a better prediction for the diagnosis of RA than use only one isotype and the ACPA alone.ResultsThe ROC showed a sensitivity and specificity of the different antibodies with different cut-off points, being the best for the IgM with 0.802 followed by ACPA, IgA and IgG with 0.771, 0.63, and 0.728 respectively without statistical difference, the sensitivity and specificity of the combination of the 4 antibodies were 81.4 and 73.66%.ConclusionIn non-selected patients with inflammatory arthralgia, the combination of ACPA and isotypes of RF did not demonstrate more sensibility and specificity than IgM isoform of rheumatoid factor measurement only. We recommend that in the clinical scenario of arthralgia, where the diagnoses are Lupus, Sjogren syndrome and Osteoarthritis, RF IgM isoform is used followed by ACPA.(AU)

Introduccion/objetivosLa artrtitis reumatoide (AR) es una enfermedad inflamatoria crónica caracterizada por inflamación, sensibilidad y destrucción de la membrana sinovial de las articulaciones, dando lugar a una discapacidad grave y mortalidad prematura. El objetivo del estudio fue determinar la precisión diagnóstica de los 3 isotipos del factor reumatoide (RF), los anticuerpos peptídicos anti citrulinados (ACPA) y la combinación de ambos, para el diagnóstico de AR en pacientes no seleccionados con artralgia inflamatoria.MétodosFueron incluidos 129 pacientes con artralgia inflamatoria de un centro de referencia de enfermedades reumáticas de tercer nivel en Monterrey, México. Sus muestras se analizaron para determinar los isotipos de RF (IgA, IgG e IgM) mediante ELISA (Euroinmun), usando un límite de 20UI/ml, y de 5UI/ml de ACPA. Se realizó un examen médico para obtener los diagnósticos definitivos de los pacientes. El análisis de los datos se realizó mediante las curvas ROC para la medición de la sensibilidad, la especificidad y la precisión diagnóstica para verificar si el uso de 3 isotipos de RF y ACPA tenía una mejor predicción para el diagnóstico de la AR que el uso de un solo isotipo y el ACPA solo.ResultadosLa curva ROC mostró una sensibilidad y especificidad de los diferentes anticuerpos con diferentes puntos de corte, siendo el mejor para el IgM con 0,802 seguido de ACPA, IgA e IgG con 0,771, 0,63 y 0,728, respectivamente, sin diferencia estadística; la sensibilidad y la especificidad de la combinación de los 4 anticuerpos fueron 81,4 y 73,66%.ConclusiónEn pacientes no seleccionados con artralgia inflamatoria, la combinación de ACPA e isotipos de RF no demostró más sensibilidad y especificidad que la isoforma IgM de la medición del RF solamente. Recomendamos que, en el escenario clínico de artralgia, donde los diagnósticos son lupus, síndrome de Sjögren y osteoartritis, se use la isoforma RF IgM seguida de los ACPA.(AU)