Detalhe da pesquisa
1.
Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia.
Blood
; 141(17): 2114-2126, 2023 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36720090
2.
Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia.
Haematologica
; 107(4): 825-835, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33853293
3.
Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models.
Haematologica
; 105(3): 697-707, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123034
4.
Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Commun Med (Lond)
; 3(1): 154, 2023 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37880389
5.
MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma.
Cell Death Dis
; 13(1): 63, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35042842
6.
Free radicals and redox signalling in T-cells during chronic inflammation and ageing.
Biochem Soc Trans
; 39(5): 1273-8, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21936801
7.
Structure-Based Design of A-1293102, a Potent and Selective BCL-XL Inhibitor.
ACS Med Chem Lett
; 12(6): 1011-1016, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141086
8.
Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors.
Cancer Res
; 81(12): 3402-3414, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33687950
9.
Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors.
ACS Med Chem Lett
; 12(7): 1108-1115, 2021 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34267880
10.
Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Mol Cancer Ther
; 20(6): 999-1008, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785651
11.
Inhibition of cyclin-dependent kinase 9 synergistically enhances venetoclax activity in mantle cell lymphoma.
EJHaem
; 1(1): 161-169, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35847704
12.
5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis.
Clin Cancer Res
; 26(13): 3371-3383, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32054729
13.
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies.
Leukemia
; 34(6): 1646-1657, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31827241
14.
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor.
ACS Med Chem Lett
; 11(10): 1829-1836, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062160
15.
Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L).
Bioorg Med Chem Lett
; 19(9): 2429-34, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19349174
16.
Assays to measure p53-dependent and -independent apoptosis.
Methods Mol Biol
; 559: 143-59, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19609755
17.
Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases.
Cancer Res
; 67(2): 756-64, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234787
18.
Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae.
Cancer Res
; 65(24): 11447-58, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16357153
19.
Enasidenib-induced differentiation promotes sensitivity to venetoclax in IDH2-mutated acute myeloid leukemia.
Leukemia
; 36(3): 869-872, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34743189
20.
Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells.
Oncotarget
; 7(43): 70000-70010, 2016 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27661108