1.
Bioorg Med Chem Lett
; 12(12): 1613-5, 2002 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12039574
RESUMO
A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).
Assuntos
3',5'-AMP Cíclico Fosfodiesterases/antagonistas & inibidores , Amidas/uso terapêutico , Antiasmáticos/uso terapêutico , Asma/tratamento farmacológico , Inibidores de Fosfodiesterase/uso terapêutico , Amidas/farmacologia , Antiasmáticos/farmacologia , Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 , Humanos , Inibidores de Fosfodiesterase/farmacologia
2.
Bioorg Med Chem Lett
; 12(12): 1617-9, 2002 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12039575
RESUMO
The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4).
Assuntos
3',5'-AMP Cíclico Fosfodiesterases/antagonistas & inibidores , Inibidores de Fosfodiesterase/síntese química , Inibidores de Fosfodiesterase/farmacologia , Quinolinas/síntese química , Quinolinas/farmacologia , Animais , Área Sob a Curva , Nucleotídeo Cíclico Fosfodiesterase do Tipo 4 , Cobaias , Inibidores de Fosfodiesterase/farmacocinética , Quinolinas/farmacocinética , Vômito/induzido quimicamente
3.
Bioorg Med Chem Lett
; 12(3): 509-12, 2002 Feb 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11814830
RESUMO
The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).