Detalhe da pesquisa
1.
Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.
J Biol Chem
; 290(30): 18609-20, 2015 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085104
2.
The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins.
Traffic
; 14(4): 458-69, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23350547
3.
The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.
J Biol Chem
; 289(27): 18736-51, 2014 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24855646
4.
Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice.
Circulation
; 125(7): 894-901, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22261195
5.
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.
J Biol Chem
; 284(42): 28856-64, 2009 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19635789
6.
The activation and physiological functions of the proprotein convertases.
Int J Biochem Cell Biol
; 40(6-7): 1111-25, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18343183
7.
Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain.
PLoS One
; 11(6): e0157230, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27280970
8.
GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation.
Cell Rep
; 13(10): 2064-71, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26628375
9.
The anti-hypercholesterolemic effect of low p53 expression protects vascular endothelial function in mice.
PLoS One
; 9(3): e92394, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24647794
10.
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol.
Drug Des Devel Ther
; 7: 1135-48, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24115837
11.
Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.
PLoS One
; 7(7): e41865, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22848640
12.
Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels.
J Biol Chem
; 283(46): 31791-801, 2008 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18799458
13.
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.
J Biol Chem
; 283(4): 2363-72, 2008 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18039658
14.
Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system.
J Neurochem
; 98(3): 838-50, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16893422