RESUMO
Rats administered 20 milligrams of magnesium pemoline per kilo gram of body weight learned to avoid shock in a jump-out apparatus in fewer trials than did controls. However, the results suggested that the principal effect of the drug was to facilitate the avoidance behavior of those animals that tended to "freeze" in response to electric grid shock. No differences in retention were observed between experimental and control animals that had achieved equal levels of learnine.
Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Estimulantes do Sistema Nervoso Central/farmacologia , Condicionamento Psicológico/efeitos dos fármacos , Animais , Condicionamento Clássico , Estimulação Elétrica , Masculino , Pemolina/farmacologia , RatosRESUMO
Phenylketonuria was induced in hooded rats by the conventional procedure of feeding excessive quantities of L-phenylalanine after weaning. Although this procedure reliably induced large, dose-dependent deficits in performance on a water maze, the behavioral deficits were completely eliminated after cessation of phenylalanine loading. These results cast doubt on the assumption that this animal preparation adequately simulates the irreversible intellectual impairments found in the child with late-detected phenylketonuria.