RESUMO
The immunogenicity of a virus-induced rat osteosarcoma was studied utilizing the lymphocyte microcytotoxicity test. Intratibial injection of murine sarcoma virus (Moloney) resulted in the development of palpable tumors at the injection site which on histopathological examination appeared to be osteosarcomas. In 73 per cent of animals injected these tumors progressed and metastasized to the lungs. Lymphocytes from these "progressor" animals demonstrated an ability to kill osteosarcoma cells in vitro (as quantitated in the microcytotoxicity test) while serum from these animals abrogated or blocked the cell-mediated cytotoxicity. In the remaining animals the tumors either failed to develop or regressed spontaneously. Lymphocytes from these "regressor" animals also demonstrated cytolytic activity against osteosarcoma cells in vitro, but serum failed to block the lymphocyte-mediated cytolysis. Both regressor and progressor groups demonstrated humoral cytotoxic antibodies to tumor antigen on the basis of the ability of their serum to kill tumor cells in vitro.
Assuntos
Formação de Anticorpos , Neoplasias Ósseas/imunologia , Modelos Animais de Doenças , Imunidade Celular , Vírus da Leucemia Murina de Moloney , Osteossarcoma/imunologia , Sarcoma Experimental/imunologia , Animais , Anticorpos Antineoplásicos , Neoplasias Ósseas/microbiologia , Testes Imunológicos de Citotoxicidade , Feminino , Técnicas In Vitro , Linfócitos/imunologia , Linfocinas , Osteossarcoma/microbiologia , Ratos , Sarcoma Experimental/microbiologia , Tíbia/imunologia , Tíbia/microbiologiaRESUMO
A 38-year-old patient with the clinical picture of a progressive myopathy resembling limb girdle muscular dystrophy is presented. Muscle biopsy showed amyloid deposits in the walls of small endomysial blood vessels. There was no clinical or physiological evidence of peripheral nerve involvement, no plasma cell dyscrasia and no generalized amyloidosis. There was no muscle fiber hypertrophy, inflammation or neurogenic change. Theere was no response to steroid therapy. The etiopathogenesis of this amyloid angiopathy is undetermined. The extensive vessel involvement with amyloid deposition and the absence of changes indicative of muscular dystropyy or inflammatory myopathy leads us to favor an ischemic basis for this patient's myopathy.
Assuntos
Amiloidose/complicações , Doenças Musculares/complicações , Adulto , Amiloidose/diagnóstico , Amiloidose/patologia , Diagnóstico Diferencial , Humanos , Masculino , Músculos/patologia , Doenças Musculares/patologia , Distrofias Musculares/diagnósticoRESUMO
A case of synovial chondromatosis affecting the temporomandibular joint is reported and the literature is reviewed. Chondromatosis occurs most frequently in this joint in middle-aged women, and it presents with pain and tenderness over the joint. Radiologically, the condition is detected by widening of the joint space with variable presence of radiodense loose bodies. Pathologically, the loose bodies in the case presented were demonstrated arise from cartilaginous metaplasia of the synovial lining. The stimulus for synovial chondrometaplasia at this site is unknown.