The coax monopole antenna: A flexible end-fed antenna for ultrahigh field transmit/receive arrays.

PURPOSE: The coax monopole antenna is presented for body imaging at 7 T. The antenna is fed at one end, eliminating the possibility of cable-coil coupling and simplifying cable routing. Additionally, its flexibility improves loading to the subject. METHODS: Like the coax dipole antenna, an interruption in the shield of the coaxial cable allows the current to extend to the outside of the shield, generating a B1 + field. Matching is achieved using a single inductor at the distal side, and a cable trap enforces the desired antenna length. Finite difference time domain simulations are employed to optimize the design parameters. Phantom measurements are conducted to determine the antenna's B1 + efficiency and to find the S-parameters in straight and bent positions. Eight-channel simulations and measurements are performed for prostate imaging. RESULTS: The optimal configuration is a length of 360 mm with a gap position of 40 mm. Simulation data show higher B1 + levels for the coax monopole (20% in the prostate), albeit with a 5% lower specific absorbance rate efficiency, compared to the fractionated dipole antenna. The S11 of the coax monopole exhibits remarkable robustness to loading changes. In vivo prostate imaging demonstrates B1 + levels of 10-14 µT with an input power of 8 × 800 W, which is comparable to the fractionated dipole antenna. High-quality images and acceptable coupling levels were achieved. CONCLUSION: The coax monopole is a novel, flexible antenna for body imaging at 7 T. Its simple design incorporates a single inductor at the distal side to achieve matching, and one-sided feeding greatly simplifies cable routing.

An improved method to measure transfer functions using MRI.

PURPOSE: A previously published method for MRI-based transfer function assessment makes use of the so-called transceive phase assumption (TPA). This limits its applicability to shorter leads and/or lower field strengths. A new method is presented where the background electric field is determined from both B 1 + $$ {\mathrm{B}}_1^{+} $$ - and B 1 - $$ {\mathrm{B}}_1^{-} $$ -field distributions, avoiding the TPA and making it more generally applicable. THEORY AND METHODS: These B 1 $$ {\mathrm{B}}_1 $$ -distributions are determined from a spoiled gradient echo multiflip angle acquisition. From the separated B 1 $$ {\mathrm{B}}_1 $$ -components the background electrical field and the induced current are computed. Further improvement is achieved by recasting the B 1 $$ {\mathrm{B}}_1 $$ -field model as a "magnitude squared least squares" problem. The proposed reconstruction method is used to determine transfer functions of various copper wire lengths up to 40 cm inside an elliptical ASTM phantom. The method is first tested on EM-simulated data and subsequently phantom and bench measurements are used to determine transfer functions experimentally. RESULTS: In silica reconstructions demonstrate the validity of the proposed B 1 $$ {\mathrm{B}}_1 $$ -field model resulting in highly accurate reconstructed B 1 $$ {\mathrm{B}}_1 $$ -fields, currents, incident electric fields and transfer functions. The experimental results show slight deviations in the field model, however, resulting transfer functions are accurately determined with high similarity to simulations and comparable to bench measurements. CONCLUSION: A more generally applicable method for MRI-based transfer function assessment is presented. The proposed method circumvents phase assumptions making it applicable for longer objects and/or higher field strengths. Additional improvements are implemented in the B 1 $$ {\mathrm{B}}_1 $$ -mapping method and the solution algorithm.

Multi-echo MR thermometry in the upper leg at 7 T using near-harmonic 2D reconstruction for initialization.

PURPOSE: The aim of this work is the development of a thermometry method to measure temperature increases in vivo, with a precision and accuracy sufficient for validation against thermal simulations. Such an MR thermometry model would be a valuable tool to get an indication on one of the major safety concerns in MR imaging: the tissue heating occurring due to radiofrequency (RF) exposure. To prevent excessive temperature rise, RF power deposition, expressed as specific absorption rate, cannot exceed predefined thresholds. Using these thresholds, MRI has demonstrated an extensive history of safe usage. Nevertheless, MR thermometry would be a valuable tool to address some of the unmet needs in the area of RF safety assessment, such as validation of specific absorption rate and thermal simulations, investigation of local peak temperatures during scanning, or temperature-based safety guidelines. METHODS: The harmonic initialized model-based multi-echo approach is proposed. The method combines a previously published model-based multi-echo water/fat separated approach with an also previously published near-harmonic 2D reconstruction method. The method is tested on the human thigh with a multi-transmit array at 7 T, in three volunteers, and for several RF shims. RESULTS: Precision and accuracy are improved considerably compared to a previous fat-referenced method (precision: 0.09 vs. 0.19°C). Comparison of measured temperature rise distributions to subject-specific simulated counterparts show good relative agreement for multiple RF shim settings. CONCLUSION: The high precision shows promising potential for validation purposes and other RF safety applications.

Tier-based formalism for safety assessment of custom-built radio-frequency transmit coils.

The purpose of this work is to propose a tier-based formalism for safety assessment of custom-built radio-frequency (RF) coils that balances validation effort with the effort put in determinating the safety factor. The formalism has three tier levels. Higher tiers require increased effort when validating electromagnetic simulation results but allow for less conservative safety factors. In addition, we propose a new method to calculate modeling uncertainty between simulations and measurements and a new method to propagate uncertainties in the simulation into a safety factor that minimizes the risk of underestimating the peak specific absorption rate (SAR). The new safety assessment procedure was completed for all tier levels for an eight-channel dipole array for prostate imaging at 7 T and an eight-channel dipole array for head imaging at 10.5 T, using data from two different research sites. For the 7 T body array, the validation procedure resulted in a modeling uncertainty of 77% between measured and simulated local SAR distributions. For a situation where RF shimming is performed on the prostate, average power limits of 2.4 and 4.5 W/channel were found for tiers 2 and 3, respectively. When the worst-case peak SAR among all phase settings was calculated, power limits of 1.4 and 2.7 W/channel were found for tiers 2 and 3, respectively. For the 10.5 T head array, a modeling uncertainty of 21% was found based on B1 + mapping. For the tier 2 validation, a power limit of 2.6 W/channel was calculated. The demonstrated tier system provides a strategy for evaluating modeling inaccuracy, allowing for the rapid translation of novel coil designs with conservative safety factors and the implementation of less conservative safety factors for frequently used coil arrays at the expense of increased validation effort.

Deep learning based correction of RF field induced inhomogeneities for T2w prostate imaging at 7 T.

At ultrahigh field strengths images of the body are hampered by B1 -field inhomogeneities. These present themselves as inhomogeneous signal intensity and contrast, which is regarded as a "bias field" to the ideal image. Current bias field correction methods, such as the N4 algorithm, assume a low frequency bias field, which is not sufficiently valid for T2w images at 7 T. In this work we propose a deep learning based bias field correction method to address this issue for T2w prostate images at 7 T. By combining simulated B1 -field distributions of a multi-transmit setup at 7 T with T2w prostate images at 1.5 T, we generated artificial 7 T images for which the homogeneous counterpart was available. Using these paired data, we trained a neural network to correct the bias field. We predicted either a homogeneous image (t-Image neural network) or the bias field (t-Biasf neural network). In addition, we experimented with the single-channel images of the receive array and the corresponding sum of magnitudes of this array as the input image. Testing was carried out on four datasets: the test split of the synthetic training dataset, volunteer and patient images at 7 T, and patient images at 3 T. For the test split, the performance was evaluated using the structural similarity index measure, Wasserstein distance, and root mean squared error. For all other test data, the features Homogeneity and Energy derived from the gray level co-occurrence matrix (GLCM) were used to quantify the improvement. For each test dataset, the proposed method was compared with the current gold standard: the N4 algorithm. Additionally, a questionnaire was filled out by two clinical experts to assess the homogeneity and contrast preservation of the 7 T datasets. All four proposed neural networks were able to substantially reduce the B1 -field induced inhomogeneities in T2w 7 T prostate images. By visual inspection, the images clearly look more homogeneous, which is confirmed by the increase in Homogeneity and Energy in the GLCM, and the questionnaire scores from two clinical experts. Occasionally, changes in contrast within the prostate were observed, although much less for the t-Biasf network than for the t-Image network. Further, results on the 3 T dataset demonstrate that the proposed learning based approach is on par with the N4 algorithm. The results demonstrate that the trained networks were capable of reducing the B1 -field induced inhomogeneities for prostate imaging at 7 T. The quantitative evaluation showed that all proposed learning based correction techniques outperformed the N4 algorithm. Of the investigated methods, the single-channel t-Biasf neural network proves most reliable for bias field correction.

Simulation-based evaluation of SAR and flip angle homogeneity for five transmit head arrays at 14 T.

INTRODUCTION: Various research sites are pursuing 14 T MRI systems. However, both local SAR and RF transmit field inhomogeneity will increase. The aim of this simulation study is to investigate the trade-offs between peak local SAR and flip angle uniformity for five transmit coil array designs at 14 T in comparison to 7 T. METHODS: Investigated coil array designs are: 8 dipole antennas (8D), 16 dipole antennas (16D), 8 loop coils (8D), 16 loop coils (16L), 8 dipoles/8 loop coils (8D8L) and for reference 8 dipoles at 7 T. Both RF shimming and kT-points were investigated by plotting L-curves of peak SAR levels vs flip angle homogeneity. RESULTS: For RF shimming, the 16L array performs best. For kT-points, superior flip angle homogeneity is achieved at the expense of more power deposition, and the dipole arrays outperform the loop coil arrays. DISCUSSION AND CONCLUSION: For most arrays and regular imaging, the constraint on head SAR is reached before constraints on peak local SAR are violated. Furthermore, the different drive vectors in kT-points alleviate strong peaks in local SAR. Flip angle inhomogeneity can be alleviated by kT-points at the expense of larger power deposition. For kT-points, the dipole arrays seem to outperform loop coil arrays.

The Coax Dipole: A fully flexible coaxial cable dipole antenna with flattened current distribution for body imaging at 7 Tesla.

PURPOSE: The coax dipole antenna, a flexible antenna for body imaging at 7T is presented. Similar to the high impedance coil, this coaxial cable antenna is fed on the central conductor and through gaps in the shield, the current passes to the outside of the antenna to generate B1 field. This could achieve more favorable current distributions and better adaptation to the body curvature. METHODS: Finite difference time domain (FDTD) simulations are performed to optimize the positions of the gaps in the shield for a flat current profile. Lumped inductors are added to each end to reduce losses. The performance of a single antenna is compared to a fractionated dipole using B1 maps and MR thermometry. Finally, an array of eight coax dipoles is evaluated in simulations and used for in-vivo scanning. RESULTS: An optimal configuration is found with gaps located at 10 cm from the center and inductor values of 28 nH. In comparison to the fractionated dipole antenna, in single antenna phantom measurements the coax dipole achieves similar B1 amplitude with 18% lower peak temperature. In simulations, the eight-channel array of coax dipoles improved B1 homogeneity by 18%, along with small improvements in transmit efficiency and specific absorption rate (SAR). MRI measurements on three volunteers show more consistent performance for the coax dipoles. CONCLUSION: The coax dipole is a novel antenna design with a flattened current distribution resulting in beneficial properties. Also, the flexible design of the coax dipoles allows better adaptation to the body curvature and can potentially be used for a wide range of imaging targets.

A single setup approach for the MRI-based measurement and validation of the transfer function of elongated medical implants.

PURPOSE: To propose a single setup using the MRI to both measure and validate the transfer function (TF) of linear implants. Conventionally, the TF of an implant is measured in one bench setup and validated using another. METHODS: It has been shown that the TF can be measured using MRI. To validate this measurement, the implant is exposed to different incident electric fields, while the temperature increase at the tip is monitored. For a good validation, the incident electric fields that the implant is exposed to should be orthogonal. We perform a simulation study on six different methods that change the incident electric field. Afterward, a TF measurement and validation study using the best method from the simulations is performed. This is done with fiberoptic temperature probes at 1.5 T for four linear implant structures using the proposed single setup. RESULTS: The simulation study showed that positioning local transmit coils at different locations along the lead trajectory has a similar validation quality compared with changing the implant trajectory (ie, the conventional validation method). For the validation study that was performed, an R2 ≥ 0.91 was found for the four investigated leads. CONCLUSION: A single setup to both measure and validate the transfer function using local transmit coils has been shown to work. The benefits of using the proposed validation method are that there is only one setup required instead of two and the implant trajectory is not varied; therefore, the relative distance between the leap tip and the temperature probe is constant.

Real-time assessment of potential peak local specific absorption rate value without phase monitoring: Trigonometric maximization method for worst-case local specific absorption rate determination.

PURPOSE: Multi-transmit MRI systems are typically equipped with dedicated hardware to sample the reflected/lost power in the transmit channels. After extensive calibration, the amplitude and phase of the signal at the feed of each array element can be accurately determined. However, determining the phase is more difficult and monitoring errors can lead to a hazardous peak local specific absorption rate (pSAR10g ) underestimation. For this purpose, methods were published for online maximum potential pSAR10g estimation without relying on phase monitoring, but these methods produce considerable overestimation. We present a trigonometric maximization method to determine the actual worst-case pSAR10g without any overestimation. THEORY AND METHOD: The proposed method takes advantage of the sinusoidal relation between the SAR10g in each voxel and the phases of input signals, to return the maximum achievable SAR10g in a few iterations. The method is applied to determine the worst-case pSAR10g for three multi-transmit array configurations at 7T: (1) body array with eight fractionated dipoles; (2) head array with eight fractionated dipoles; (3) head array with eight rectangular loops. The obtained worst-case pSAR10g values are compared with the pSAR10g values determined with a commonly used method and with a more efficient method based on reference-phases. RESULTS: For each voxel, the maximum achievable SAR10g is determined in less than 0.1 ms. Compared to the reference-phases-based method, the proposed method reduces the mean overestimation of the actual pSAR10g up to 52%, while never underestimating the true pSAR10g . CONCLUSION: The proposed method can widely improve the performance of parallel transmission MRI systems without phase monitoring.

SAR and temperature distributions in a database of realistic human models for 7 T cardiac imaging.

PURPOSE: To investigate inter-subject variability of B1+ , SAR and temperature rise in a database of human models using a local transmit array for 7 T cardiac imaging. METHODS: Dixon images were acquired of 14 subjects and segmented in dielectric models with an eight-channel local transmit array positioned around the torso for cardiac imaging. EM simulations were done to calculate SAR distributions. Based on the SAR distributions, temperature simulations were performed for exposure times of 6 min and 30 min. Peak local SAR and temperature rise levels were calculated for different RF shim settings. A statistical analysis of the resulting peak local SAR and temperature rise levels was performed to arrive at safe power limits. RESULTS: For RF shim vectors with random phase and uniformly distributed power, a safe average power limit of 35.7 W was determined (first level controlled mode). When RF amplitude and phase shimming was performed on the heart, a safe average power limit of 35.0 W was found. According to Pennes' model, our numerical study suggests a very low probability of exceeding the absolute local temperature limit of 40 °C for a total exposure time of 6 min and a peak local SAR of 20 W/kg. For a 30 min exposure time at 20 W/kg, it was shown that the absolute temperature limit can be exceeded in the case where perfusion does not change with temperature. CONCLUSION: Safe power constraints were found for 7 T cardiac imaging with an eight-channel local transmit array, while considering the inter-subject variability of B1+ , SAR and temperature rise.

7T MR Safety.

Magnetic resonance imaging and spectroscopy (MRI/MRS) at 7T represents an exciting advance in MR technology, with intriguing possibilities to enhance image spatial, spectral, and contrast resolution. To ensure the safe use of this technology while still harnessing its potential, clinical staff and researchers need to be cognizant of some safety concerns arising from the increased magnetic field strength and higher Larmor frequency. The higher static magnetic fields give rise to enhanced transient bioeffects and an increased risk of adverse incidents related to electrically conductive implants. Many technical challenges remain and the continuing rapid pace of development of 7T MRI/MRS is likely to present further challenges to ensuring safety of this technology in the years ahead. The recent regulatory clearance for clinical diagnostic imaging at 7T will likely increase the installed base of 7T systems, particularly in hospital environments with little prior ultrahigh-field MR experience. Informed risk/benefit analyses will be required, particularly where implant manufacturer-published 7T safety guidelines for implants are unavailable. On behalf of the International Society for Magnetic Resonance in Medicine, the aim of this article is to provide a reference document to assist institutions developing local institutional policies and procedures that are specific to the safe operation of 7T MRI/MRS. Details of current 7T technology and the physics underpinning its functionality are reviewed, with the aim of supporting efforts to expand the use of 7T MRI/MRS in both research and clinical environments. Current gaps in knowledge are also identified, where additional research and development are required. Level of Evidence 5 Technical Efficacy 2 J. MAGN. RESON. IMAGING 2021;53:333-346.

MRI-based transfer function determination through the transfer matrix by jointly fitting the incident and scattered B1+ field.

PURPOSE: A purely experimental method for MRI-based transfer function (TF) determination is presented. A TF characterizes the potential for radiofrequency heating of a linear implant by relating the incident tangential electric field to a scattered electric field at its tip. We utilize the previously introduced transfer matrix (TM) to determine transfer functions solely from the MR measurable quantities, that is, the B1+ and transceive phase distributions. This technique can extend the current practice of phantom-based TF assessment with dedicated experimental setup toward MR-based methods that have the potential to assess the TF in more realistic situations. THEORY AND METHODS: An analytical description of the B1+ magnitude and transceive phase distribution around a wire-like implant was derived based on the TM. In this model, the background field is described using a superposition of spherical and cylindrical harmonics while the transfer matrix is parameterized using a previously introduced attenuated wave model. This analytical description can be used to estimate the transfer matrix and transfer function based on the measured B1+ distribution. RESULTS: The TF was successfully determined for 2 mock-up implants: a 20-cm bare copper wire and a 20-cm insulated copper wire with 10 mm of insulation stripped at both endings in respectively 4 and 3 different trajectories. The measured TFs show a strong correlation with a reference determined from simulations and between the separate experiments with correlation coefficients above 0.96 between all TFs. Compared to the simulated TF, the maximum deviation in the estimated tip field is 9.4% and 12.2% for the bare and insulated wire, respectively. CONCLUSIONS: A method has been developed to measure the TF of medical implants using MRI experiments. Jointly fitting the incident and scattered B1+ distributions with an analytical description based on the transfer matrix enables accurate determination of the TF of 2 test implants. The presented method no longer needs input from simulated data and can therefore, in principle, be used to measure TF's in test animals or corpses.

Conditional safety margins for less conservative peak local SAR assessment: A probabilistic approach.

PURPOSE: The introduction of a linear safety factor to address peak local specific absorption rate (pSAR10g ) uncertainties (eg, intersubject variation, modeling inaccuracies) bears one considerable drawback: It often results in over-conservative scanning constraints. We present a more efficient approach to define a variable safety margin based on the conditional probability density function of the effectively obtained pSAR10g value, given the estimated pSAR10g value. METHODS: The conditional probability density function can be estimated from previously simulated data. A representative set of true and estimated pSAR10g samples was generated by means of our database of 23 subject-specific models with an 8-fractionated dipole array for prostate imaging at 7 T. The conditional probability density function was calculated for each possible estimated pSAR10g value and used to determine the corresponding safety margin with an arbitrary low probability of underestimation. This approach was applied to five state-of-the-art local SAR estimation methods, namely: (1) using just the generic body model "Duke"; (2) using our model library to assess the maximum pSAR10g value over all models; (3) using the most representative "local SAR model"; (4) using the five most representative local SAR models; and (5) using a recently developed deep learning-based method. RESULTS: Compared with the more conventional safety factor, the conditional safety-margin approach results in lower (up to 30%) mean overestimation for all investigated local SAR estimation methods. CONCLUSION: The proposed probabilistic approach for pSAR10g correction allows more accurate local SAR assessment with much lower overestimation, while a predefined level of underestimation is accepted (eg, 0.1%).

Accelerating implant RF safety assessment using a low-rank inverse update method.

PURPOSE: Patients who have medical metallic implants, e.g. orthopaedic implants and pacemakers, often cannot undergo an MRI exam. One of the largest risks is tissue heating due to the radio frequency (RF) fields. The RF safety assessment of implants is computationally demanding. This is due to the large dimensions of the transmit coil compared to the very detailed geometry of an implant. METHODS: In this work, we explore a faster computational method for the RF safety assessment of implants that exploits the small geometry. The method requires the RF field without an implant as a basis and calculates the perturbation that the implant induces. The inputs for this method are the incident fields and a library matrix that contains the RF field response of every edge an implant can occupy. Through a low-rank inverse update, using the Sherman-Woodbury-Morrison matrix identity, the EM response of arbitrary implants can be computed within seconds. We compare the solution from full-wave simulations with the results from the presented method, for two implant geometries. RESULTS: From the comparison, we found that the resulting electric and magnetic fields are numerically equivalent (maximum error of 1.35%). However, the computation was between 171 to 2478 times faster than the corresponding GPU accelerated full-wave simulation. CONCLUSIONS: The presented method enables for rapid and efficient evaluation of the RF fields near implants and might enable situation-specific scanning conditions.

Intersubject specific absorption rate variability analysis through construction of 23 realistic body models for prostate imaging at 7T.

PURPOSE: For ultrahigh field (UHF) MRI, the expected local specific absorption rate (SAR) distribution is usually calculated by numerical simulations using a limited number of generic body models and adding a safety margin to take into account intersubject variability. Assessment of this variability with a large model database would be desirable. In this study, a procedure to create such a database with accurate subject-specific models is presented. Using 23 models, intersubject variability is investigated for prostate imaging at 7T with an 8-channel fractionated dipole antenna array with 16 receive loops. METHOD: From Dixon images of a volunteer acquired at 1.5T with a mockup array in place, an accurate dielectric model is built. Following this procedure, 23 subject-specific models for local SAR assessment at 7T were created enabling an extensive analysis of the intersubject B1+ and peak local SAR variability. RESULTS: For the investigated setup, the maximum possible peak local SAR ranges from 2.6 to 4.6 W/kg for 8 × 1 W input power. The expected peak local SAR values represent a Gaussian distribution (µ/σ=2.29/0.29 W/kg) with realistic prostate-shimmed phase settings and a gamma distribution Γ(24,0.09) with multidimensional radiofrequency pulses. Prostate-shimmed phase settings are similar for all models. Using 1 generic phase setting, average B1+ reduction is 7%. Using only 1 model, the required safety margin for intersubject variability is 1.6 to 1.8. CONCLUSION: The presented procedure allows for the creation of a customized model database. The results provide valuable insights into B1+ and local SAR variability. Recommended power thresholds per channel are 3.1 W with phase shimming on prostate or 2.6 W for multidimensional pulses.

Homogeneous B1+ for bilateral breast imaging at 7 T using a five dipole transmit array merged with a high density receive loop array.

To explore the use of five meandering dipole antennas in a multi-transmit setup, combined with a high density receive array for breast imaging at 7 T for improved penetration depth and more homogeneous B1 field. Five meandering dipole antennas and 30 receiver loops were positioned on two cups around the breasts. Finite difference time domain simulations were performed to evaluate RF safety limits of the transmit setup. Scattering parameters of the transmit setup and coupling between the antennas and the detuned loops were measured. In vivo parallel imaging performance was investigated for various acceleration factors. After RF shimming, a B1 map, a T1 -weighted image, and a T2 -weighted image were acquired to assess B1 efficiency, uniformity in contrast weighting, and imaging performance in clinical applications. The maximum achievable local SAR10g value was 7.0 W/kg for 5 × 1 W accepted power. The dipoles were tuned and matched to a maximum reflection of -11.8 dB, and a maximum inter-element coupling of -14.2 dB. The maximum coupling between the antennas and the receive loops was -18.2 dB and the mean noise correlation for the 30 receive loops 7.83 ± 8.69%. In vivo measurements showed an increased field of view, which reached to the axilla, and a high transmit efficiency. This coil enabled the acquisition of T1 -weighted images with a high spatial resolution of 0.7 mm3 isotropic and T2 -weighted spin echo images with uniformly weighted contrast.

Comparing signal-to-noise ratio for prostate imaging at 7T and 3T.

BACKGROUND: In MRI, the signal-to-noise ratio (SNR) theoretically increases with B0 field strength. However, because of attenuation of the radiofrequency (RF) fields at 7T, it is not certain if this SNR gain can be realized for prostate imaging. PURPOSE/HYPOTHESIS: To investigate the SNR gain in prostate imaging at 7T as compared with 3T. It is expected that SNR will improve for prostate imaging at 7T compared with 3T. STUDY TYPE: Prospective. SUBJECTS: Four healthy volunteers and one prostate cancer patient. FIELD STRENGTH/SEQUENCE: All subjects were scanned at 3T and at 7T using optimal coil setups for both field strengths. For all volunteers, proton density-weighted images were acquired for SNR analysis and actual flip angle imaging (AFI) B1+| maps were acquired for correction of measured SNR values. In the patient, a T2 -weighted (T2 w) image was acquired at 3T and at 7T. ASSESSMENT: SNR was calculated in the prostate region for all volunteers. SNR was normalized for flip angle, receiver bandwidth, and voxel volume. SNR was also calculated for different sensitivity encoding (SENSE) acceleration factors. STATISTICAL TESTING: SNR values are represented as the arithmetic mean of SNR values in the prostate. Estimated SNR in the T2 w image is calculated as the arithmetic mean of the signal intensity (SI) divided by the standard deviation of the SI in a specified zone. Tumor-to-tissue contrast is calculated as (SItumor +SIzone )/( SItumor -SIzone ). RESULTS: An increase in SNR ranging from 1.7-fold to 2.8-fold was measured in the prostate at 7T in comparison to 3T for four volunteers. At 7T, it is possible to achieve a 4-fold SENSE acceleration in the left-right direction with similar SNR to a nonaccelerated 3T image. T2 w imaging was done at 3T and 7T in one patient, where improved tumor-to-tissue contrast was demonstrated at 7T. DATA CONCLUSION: SNR improves for prostate imaging at 7T as compared with 3T. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:1446-1455.

MRI-based, wireless determination of the transfer function of a linear implant: Introduction of the transfer matrix.

PURPOSE: We introduce the transfer matrix (TM) that makes MR-based wireless determination of transfer functions (TFs) possible. TFs are implant specific measures for RF-safety assessment of linear implants. The TF relates an incident tangential electric field on an implant to a scattered electric field at its tip that generally governs local heating. The TM extends this concept and relates an incident tangential electric field to a current distribution in the implant therewith characterizing the RF response along the entire implant. The TM is exploited to measure TFs with MRI without hardware alterations. THEORY AND METHODS: A model of rightward and leftward propagating attenuated waves undergoing multiple reflections is used to derive an analytical expression for the TM. This allows parameterization of the TM of generic implants, e.g., (partially) insulated single wires, in a homogeneous medium in a few unknowns that simultaneously describe the TF. These unknowns can be determined with MRI making it possible to measure the TM and, therefore, also the TF. RESULTS: The TM is able to predict an induced current due to an incident electric field and can be accurately parameterized with a limited number of unknowns. Using this description the TF is determined accurately (with a Pearson correlation coefficient R ≥ 0.9 between measurements and simulations) from MRI acquisitions. CONCLUSION: The TM enables measuring of TFs with MRI of the tested generic implant models. The MR-based method does not need hardware alterations and is wireless hence making TF determination in more realistic scenarios conceivable.

Estimating B1+ in the breast at 7 T using a generic template.

Dynamic contrast-enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B1+ ) field inhomogeneities. B1+ field information is required in order to correct these. The use of a generic, coil-specific B1+ template is proposed and tested. Finite-difference time-domain simulations for B1+ were performed for healthy female volunteers with a wide range of breast anatomies. A generic B1+ template was constructed by averaging simulations based on four volunteers. Three-dimensional B1+ maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B1+ mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00-4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1-16%, with mean 11.7%. The agreement between the proposed template approach and a B1+ mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B1+ template. With local RF transmit coils, intersubject differences in B1+ fields of the breast are comparable to the accuracy of B1+ mapping methods, even at 7 T. Consequently, a single generic B1+ template suits subjects over a wide range of breast anatomies, eliminating the need for a time-consuming B1+ mapping protocol.

Design of a forward view antenna for prostate imaging at 7 T.

PURPOSE: To design a forward view antenna for prostate imaging at 7 T, which is placed between the legs of the subject in addition to a dipole array. MATERIALS AND METHODS: The forward view antenna is realized by placing a cross-dipole antenna at the end of a small rectangular waveguide. Quadrature drive of the cross-dipole can excite a circularly polarized wave propagating along the axial direction to and from the prostate region. Functioning of the forward view antenna is validated by comparing measurements and simulations. Antenna performance is evaluated by numerical simulations and measurements at 7 T. RESULTS: Simulations of B1+ on a phantom are in good correspondence with measurements. Simulations on a human model indicate that the signal-to-noise ratio (SNR), specific absorption rate (SAR) efficiency and SAR increase when adding the forward view antenna to a previously published dipole array. The SNR increases by up to 18% when adding the forward view antenna as a receive antenna to an eight-channel dipole array in vivo. CONCLUSIONS: A design for a forward view antenna is presented and evaluated. SNR improvements up to 18% are demonstrated when adding the forward view antenna to a dipole array.