Detalhe da pesquisa
1.
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.
Proc Natl Acad Sci U S A
; 120(25): e2218896120, 2023 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37327313
2.
XBP1 variant 1 promotes mitosis of cancer cells involving upregulation of the polyglutamylase TTLL6.
Hum Mol Genet
; 31(15): 2639-2654, 2022 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35333353
3.
Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma.
Brain
; 146(4): 1697-1713, 2023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36148553
4.
A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators.
J Biol Chem
; 298(12): 102705, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36400200
5.
Structure-activity relationship of ipglycermide binding to phosphoglycerate mutases.
J Biol Chem
; 296: 100628, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33812994
6.
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.
J Biol Chem
; 297(4): 101191, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520759
7.
A 12-lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish.
FASEB J
; 34(11): 14850-14862, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32918516
8.
KDM5 histone demethylases repress immune response via suppression of STING.
PLoS Biol
; 16(8): e2006134, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30080846
9.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
10.
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg Med Chem
; 46: 116349, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500187
11.
SCAM Detective: Accurate Predictor of Small, Colloidally Aggregating Molecules.
J Chem Inf Model
; 60(8): 4056-4063, 2020 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32678597
12.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Nat Chem Biol
; 12(6): 452-8, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27110680
13.
Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Bioorg Med Chem
; 26(8): 1727-1739, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555419
14.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Proc Natl Acad Sci U S A
; 111(6): 2349-54, 2014 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24469833
15.
Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants.
Retrovirology
; 13: 11, 2016 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26880034
16.
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.
Diabetologia
; 58(3): 549-57, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25417214
17.
Discovery of a novel general anesthetic chemotype using high-throughput screening.
Anesthesiology
; 122(2): 325-33, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25603205
18.
RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma.
Cancer Immunol Res
; 12(2): 180-194, 2024 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051215
19.
Methotrexate-based PROTACs as DHFR-specific chemical probes.
Cell Chem Biol
; 31(2): 221-233.e14, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37875111
20.
Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.
Biochemistry
; 52(24): 4193-203, 2013 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713684