Detalhe da pesquisa
1.
A quantitative systems pharmacological approach identified activation of JNK signaling pathway as a promising treatment strategy for refractory HER2 positive breast cancer.
J Pharmacokinet Pharmacodyn
; 48(2): 273-293, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33389550
2.
Network-Based Analysis of Bortezomib Pharmacodynamic Heterogeneity in Multiple Myeloma Cells.
J Pharmacol Exp Ther
; 365(3): 734-751, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29632237
3.
Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice.
Drug Metab Dispos
; 44(2): 189-208, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26586377
4.
Modeling Alzheimer's disease progression utilizing clinical trial and ADNI data to predict longitudinal trajectory of CDR-SB.
CPT Pharmacometrics Syst Pharmacol
; 12(7): 1029-1042, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37101394
5.
Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet.
Neurology
; 101(14): e1391-e1401, 2023 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37643887
6.
A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers.
Clin Transl Sci
; 16(10): 1997-2009, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37596814
7.
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
CPT Pharmacometrics Syst Pharmacol
; 12(1): 62-73, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36281062
8.
Hallmarks of neurodegenerative disease: A systems pharmacology perspective.
CPT Pharmacometrics Syst Pharmacol
; 11(11): 1399-1429, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35894182
9.
Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial.
JAMA Neurol
; 79(8): 758-767, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696185
10.
gQSPSim: A SimBiology-Based GUI for Standardized QSP Model Development and Application.
CPT Pharmacometrics Syst Pharmacol
; 9(3): 165-176, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31957304
11.
A Review on Drug-Induced Nephrotoxicity: Pathophysiological Mechanisms, Drug Classes, Clinical Management, and Recent Advances in Mathematical Modeling and Simulation Approaches.
Clin Pharmacol Drug Dev
; 9(8): 896-909, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33025766
12.
Pharmacodynamic Models of Differential Bortezomib Signaling Across Several Cell Lines of Multiple Myeloma.
CPT Pharmacometrics Syst Pharmacol
; 8(3): 146-157, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30516019
13.
Effect of salt on the hybridization of DNA by sequential immobilization of oligonucleotides at the air-water interface in the presence of ODA/DOTAP monolayers.
J Colloid Interface Sci
; 276(1): 77-84, 2004 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15219432