Detalhe da pesquisa
1.
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.
Nucleic Acids Res
; 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742636
2.
Drug transporters in drug disposition - the year 2022 in review.
Drug Metab Rev
; 55(4): 343-370, 2023 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37644867
3.
Innovations, Opportunities, and Challenges for Predicting Alteration in Drug-Metabolizing Enzyme and Transporter Activity in Specific Populations.
Drug Metab Dispos
; 51(12): 1547-1550, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37775331
4.
Novel insights in drug transporter sciences: the year 2021 in review.
Drug Metab Rev
; 54(3): 299-317, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35762758
5.
Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model.
Drug Metab Dispos
; 50(2): 114-127, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34789487
6.
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human.
Drug Metab Dispos
; 50(6): 781-797, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34154993
7.
ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs).
Xenobiotica
; 52(8): 770-785, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-36314242
8.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment.
Drug Metab Dispos
; 49(1): 94-110, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139460
9.
Evaluation of the drug-drug interaction potential for trazpiroben (TAK-906), a D2/D3 receptor antagonist for gastroparesis, towards cytochrome P450s and transporters.
Xenobiotica
; 51(6): 668-679, 2021 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33879032
10.
Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates.
Drug Metab Dispos
; 47(10): 1206-1221, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439574
11.
In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters.
Drug Metab Dispos
; 47(10): 1183-1194, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31270142
12.
Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.
Drug Metab Dispos
; 46(10): 1434-1440, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30068520
13.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.
Drug Metab Dispos
; 46(9): 1285-1303, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29959133
14.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos
; 45(10): 1049-1059, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28646080
15.
Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.
Drug Metab Dispos
; 44(10): 1720-30, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27422672
16.
Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes.
Drug Metab Dispos
; 44(3): 466-75, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26684498
17.
Mass balance, metabolite profile, and in vitro-in vivo comparison of clearance pathways of deleobuvir, a hepatitis C virus polymerase inhibitor.
Antimicrob Agents Chemother
; 59(1): 25-37, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25313217
18.
Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac.
Drug Metab Dispos
; 43(9): 1307-15, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26076693
19.
Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.
Drug Metab Dispos
; 42(11): 1940-6, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25157098
20.
Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.
Drug Metab Dispos
; 42(3): 394-406, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24366904