1.
Biomedicine
; 29(8): 276-9, 1978 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-743562
RESUMO
Administration of a bromotriphenylethylene to C3H/f(XVII/G) female mice implanted with a pituitary under the kidney capsule produces with high doses (200 mg/kg or 20 mg/kg of diet) a strong inhibition of the development of the mammary glands. With a low dose (2 mg/kg) no inhibition was observed. In mice which received the high doses no hyperplastic alveolar nodules were observed. The activity of the compound is more pronounced after 50 days than after 25 days.
Assuntos
Glândulas Mamárias Animais/efeitos dos fármacos , Estilbenos/farmacologia , Animais , Relação Dose-Resposta a Droga , Feminino , Glândulas Mamárias Animais/crescimento & desenvolvimento , Camundongos , Camundongos Endogâmicos C3H , Hipófise/fisiologia , Hipófise/transplante , Transplante Isogênico
2.
C R Seances Soc Biol Fil
; 172(5): 845-9, 1978.
Artigo
em Francês
| MEDLINE
| ID: mdl-157196
RESUMO
Administration of bromotriphenylethylene to C3H/f female mice implanted with a pituitary under the kidney capsule produce an inhibition of mammary carcinogenesis with high doses (20 ppm or 200 ppm in the diet). With a diet containing 2 ppm no inhibition is observed.