Detalhe da pesquisa
1.
S1PR3 Signaling Drives Bacterial Killing and Is Required for Survival in Bacterial Sepsis.
Am J Respir Crit Care Med
; 196(12): 1559-1570, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28850247
2.
The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition.
FASEB J
; 30(4): 1656-69, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26722006
3.
IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy.
Nat Cancer
; 2(10): 1055-1070, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121883
4.
Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor.
J Comb Chem
; 10(2): 256-66, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18271560
5.
Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts.
Cancer Res
; 64(3): 1058-66, 2004 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14871838
6.
A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity.
Aging Cell
; 13(1): 165-74, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24261972
7.
The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer.
Mol Cancer Ther
; 13(12): 2827-39, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25267499
8.
Therapeutic destruction of insulin receptor substrates for cancer treatment.
Cancer Res
; 73(14): 4383-94, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23651636
9.
Sequence-based protein kinase inhibition: applications for drug development.
Biotechniques
; 39(4): 575-6, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16235571
10.
Prevention of insulin resistance and beta-cell loss by abrogating PKCepsilon-induced serine phosphorylation of muscle IRS-1 in Psammomys obesus.
Diabetes Metab Res Rev
; 24(7): 577-84, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18613220
11.
The inhibition of Ras farnesylation leads to an increase in p27Kip1 and G1 cell cycle arrest.
Eur J Biochem
; 270(13): 2759-72, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12823546
12.
Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3).
Blood
; 102(6): 2099-107, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12763936
13.
Toward a PKB inhibitor: modification of a selective PKA inhibitor by rational design.
Biochemistry
; 41(32): 10304-14, 2002 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12162746
14.
Sequence-based design of kinase inhibitors applicable for therapeutics and target identification.
J Biol Chem
; 279(2): 1242-55, 2004 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14570903
15.
Sequence-based protein kinase inhibition: applications for drug development.
Biotechniques
; 39(10 Suppl): S575-6, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18957040