Detalhe da pesquisa
1.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779864
2.
A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes.
Drug Metab Dispos
; 47(5): 484-492, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30787098
3.
6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to ß-Estradiol.
Drug Metab Dispos
; 46(12): 1836-1846, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30194276
4.
Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines.
Drug Metab Dispos
; 46(4): 415-421, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29437874
5.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 346-356, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330218
6.
Novel Method to Predict In Vivo Liver-to-Plasma Kpuu for OATP Substrates Using Suspension Hepatocytes.
Drug Metab Dispos
; 45(5): 576-580, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28258068
7.
An exposure-response analysis based on rifampin suggests CYP3A4 induction is driven by AUC: an in vitro investigation.
Xenobiotica
; 47(8): 673-681, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27595796
8.
Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake.
Drug Metab Dispos
; 44(10): 1633-42, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27417179
9.
Systematic Evaluation of Bioorthogonal Reactions in Live Cells with Clickable HaloTag Ligands: Implications for Intracellular Imaging.
J Am Chem Soc
; 137(35): 11461-75, 2015 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26270632
10.
A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling.
J Pharmacokinet Pharmacodyn
; 41(3): 197-209, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24718648
11.
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Bioorg Med Chem Lett
; 23(1): 209-12, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200244
12.
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Bioorg Med Chem Lett
; 23(1): 213-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200254
13.
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Bioorg Med Chem Lett
; 23(1): 198-202, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200252
14.
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Bioorg Med Chem Lett
; 23(1): 203-8, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200249
15.
Evolving approaches on measurements and applications of intracellular free drug concentration and Kpuu in drug discovery.
Expert Opin Drug Metab Toxicol
; 17(7): 733-746, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34058926
16.
Estimation of the Effect of OAT2-Mediated Active Uptake on Meloxicam Exposure in the Human Liver.
AAPS J
; 22(2): 20, 2020 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31900711
17.
Comparison of Fraction Unbound Between Liver Homogenate and Hepatocytes at 4°C.
AAPS J
; 22(4): 91, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32671577
18.
Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel ß-Arrestin Antagonist Activity.
ACS Med Chem Lett
; 11(6): 1330-1334, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551020
19.
Structural attributes influencing unbound tissue distribution.
Eur J Med Chem
; 185: 111813, 2020 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31732255
20.
Evaluation of Fraction Unbound Across 7 Tissues of 5 Species.
J Pharm Sci
; 109(2): 1178-1190, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31704191