Prognostic Value of 18F-FDG PET Radiomics Features at Baseline in PET-Guided Consolidation Strategy in Diffuse Large B-Cell Lymphoma: A Machine-Learning Analysis from the GAINED Study.

The results of the GA in Newly Diagnosed Diffuse Large B-Cell Lymphoma (GAINED) study demonstrated the success of an 18F-FDG PET-driven approach to allow early identification-for intensification therapy-of diffuse large B-cell lymphoma patients with a high risk of relapse. Besides, some works have reported the prognostic value of baseline PET radiomics features (RFs). This work investigated the added value of such biomarkers on survival of patients involved in the GAINED protocol. Methods: Conventional PET features and RFs were computed from 18F-FDG PET at baseline and extracted using different volume definitions (patient level, largest lesion, and hottest lesion). Clinical features and the consolidation treatment information were also considered in the model. Two machine-learning pipelines were trained with 80% of patients and tested on the remaining 20%. The training was repeated 100 times to highlight the test set variability. For the 2-y progression-free survival (PFS) outcome, the pipeline included a data augmentation and an elastic net logistic regression model. Results for different feature groups were compared using the mean area under the curve (AUC). For the survival outcome, the pipeline included a Cox univariate model to select the features. Then, the model included a split between high- and low-risk patients using the median of a regression score based on the coefficients of a penalized Cox multivariate approach. The log-rank test P values over the 100 loops were compared with a Wilcoxon signed-ranked test. Results: In total, 545 patients were included for the 2-y PFS classification and 561 for survival analysis. Clinical features alone, consolidation features alone, conventional PET features, and RFs extracted at patient level achieved an AUC of, respectively, 0.65 ± 0.07, 0.64 ± 0.06, 0.60 ± 0.07, and 0.62 ± 0.07 (0.62 ± 0.07 for the largest lesion and 0.54 ± 0.07 for the hottest). Combining clinical features with the consolidation features led to the best AUC (0.72 ± 0.06). Adding conventional PET features or RFs did not improve the results. For survival, the log-rank P values of the model involving clinical and consolidation features together were significantly smaller than all combined-feature groups (P < 0.007). Conclusion: The results showed that a concatenation of multimodal features coupled with a simple machine-learning model does not seem to improve the results in terms of 2-y PFS classification and PFS prediction for patient treated according to the GAINED protocol.

18F-FDG-Based Radiomics and Machine Learning: Useful Help for Aortic Prosthetic Valve Infective Endocarditis Diagnosis?

BACKGROUND: Fluorine-18 fluorodeoxyglucose (18F-FDG)-positron emission tomography (PET)/computed tomography (CT) results in better sensitivity for prosthetic valve endocarditis (PVE) diagnosis, but visual image analysis results in relatively weak specificity and significant interobserver variability. OBJECTIVES: The primary objective of this study was to evaluate the performance of a radiomics and machine learning-based analysis of 18F-FDG PET/CT (PET-ML) as a major criterion for the European Society of Cardiology score using machine learning as a major imaging criterion (ESC-ML) in PVE diagnosis. The secondary objective was to assess performance of PET-ML as a standalone examination. METHODS: All 18F-FDG-PET/CT scans performed for suspected aortic PVE at a single center from 2015 to 2021 were retrospectively included. The gold standard was expert consensus after at least 3 months' follow-up. The machine learning (ML) method consisted of manually segmenting each prosthetic valve, extracting 31 radiomics features from the segmented region, and training a ridge logistic regressor to predict PVE. Training and hyperparameter tuning were done with a cross-validation approach, followed by an evaluation on an independent test database. RESULTS: A total of 108 patients were included, regardless of myocardial uptake, and were divided into training (n = 68) and test (n = 40) cohorts. Considering the latter, PET-ML findings were positive for 13 of 22 definite PVE cases and 3 of 18 rejected PVE cases (59% sensitivity, 83% specificity), thus leading to an ESC-ML sensitivity of 72% and a specificity of 83%. CONCLUSIONS: The use of ML for analyzing 18F-FDG-PET/CT images in PVE diagnosis was feasible and beneficial, particularly when ML was included in the ESC 2015 criteria. Despite some limitations and the need for future developments, this approach seems promising to optimize the role of 18F-FDG PET/CT in PVE diagnosis.

Rate-Distortion Optimized Graph Coarsening and Partitioning for Light Field Coding.

Graph-based transforms are powerful tools for signal representation and energy compaction. However, their use for high dimensional signals such as light fields poses obvious problems of complexity. To overcome this difficulty, one can consider local graph transforms defined on supports of limited dimension, which may however not allow us to fully exploit long-term signal correlation. In this paper, we present methods to optimize local graph supports in a rate distortion sense for efficient light field compression. A large graph support can be well adapted for compression efficiency, however at the expense of high complexity. In this case, we use graph reduction techniques to make the graph transform feasible. We also consider spectral clustering to reduce the dimension of the graph supports while controlling both rate and complexity. We derive the distortion and rate models which are then used to guide the graph optimization. We describe a complete light field coding scheme based on the proposed graph optimization tools. Experimental results show rate-distortion performance gains compared to the use of fixed graph support. The method also provides competitive results when compared against HEVC-based and the JPEG Pleno light field coding schemes. We also assess the method against a homography-based low rank approximation and a Fourier disparity layer based coding method.

Prediction and Sampling with Local Graph Transforms for Quasi-Lossless Light Field Compression.

Graph-based transforms have been shown to be powerful tools in terms of image energy compaction. However, when the size of the support increases to best capture signal dependencies, the computation of the basis functions becomes rapidly untractable. This problem is in particular compelling for high dimensional imaging data such as light fields. The use of local transforms with limited supports is a way to cope with this computational difficulty. Unfortunately, the locality of the support may not allow us to fully exploit long term signal dependencies present in both the spatial and angular dimensions of light fields. This paper describes sampling and prediction schemes with local graph-based transforms enabling to efficiently compact the signal energy and exploit dependencies beyond the local graph support. The proposed approach is investigated and is shown to be very efficient in the context of spatio-angular transforms for quasi-lossless compression of light fields.

Geometry-Aware Graph Transforms for Light Field Compact Representation.

The paper addresses the problem of energy compaction of dense 4D light fields by designing geometry-aware local graph-based transforms. Local graphs are constructed on super-rays that can be seen as a grouping of spatially and geometry-dependent angularly correlated pixels. Both non separable and separable transforms are considered. Despite the local support of limited size defined by the super-rays, the Laplacian matrix of the non separable graph remains of high dimension and its diagonalization to compute the transform eigen vectors remains computationally expensive. To solve this problem, we then perform the local spatio-angular transform in a separable manner. We show that when the shape of corresponding super-pixels in the different views is not isometric, the basis functions of the spatial transforms are not coherent, resulting in decreased correlation between spatial transform coefficients. We hence propose a novel transform optimization method that aims at preserving angular correlation even when the shapes of the super-pixels are not isometric. Experimental results show the benefit of the approach in terms of energy compaction. A coding scheme is also described to assess the rate-distortion perfomances of the proposed transforms and is compared to state of the art encoders namely HEVC-lozenge [1], JPEG pleno 1.1 [2], HEVC-pseudo [3] and HLRA [4].