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Cell ; 184(19): 4874-4885.e16, 2021 09 16.
Artigo em Inglês | MEDLINE | ID: mdl-34433011

RESUMO

Only five species of the once-diverse Rhinocerotidae remain, making the reconstruction of their evolutionary history a challenge to biologists since Darwin. We sequenced genomes from five rhinoceros species (three extinct and two living), which we compared to existing data from the remaining three living species and a range of outgroups. We identify an early divergence between extant African and Eurasian lineages, resolving a key debate regarding the phylogeny of extant rhinoceroses. This early Miocene (∼16 million years ago [mya]) split post-dates the land bridge formation between the Afro-Arabian and Eurasian landmasses. Our analyses also show that while rhinoceros genomes in general exhibit low levels of genome-wide diversity, heterozygosity is lowest and inbreeding is highest in the modern species. These results suggest that while low genetic diversity is a long-term feature of the family, it has been particularly exacerbated recently, likely reflecting recent anthropogenic-driven population declines.


Assuntos
Evolução Molecular , Genoma , Perissodáctilos/genética , Animais , Demografia , Fluxo Gênico , Variação Genética , Geografia , Heterozigoto , Homozigoto , Especificidade de Hospedeiro , Cadeias de Markov , Mutação/genética , Filogenia , Especificidade da Espécie , Fatores de Tempo
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