Unusual Uptake of [131I] in a Tenosynovial Giant Cell Tumour Relapse in a Patient with Differentiated Thyroid Cancer.

A 77-year-old woman with follicular thyroid cancer underwent total thyroidectomy and subsequent Iodine-131 remnant ablation. She had a history of a wide tenosynovial giant cell tumor (TGCT) of the right wrist and hand that had been resected thirteen years ago. Post-therapeutic scintigraphy and single photon emission computed tomography showed mild uptake on the distal right forearm, wrist and hand. Magnetic resonance imaging and posterior histopathology confirmed a relapse of TGCT. No radioiodine adverse effects were reported after a one-year follow-up. As far as we know, this report is the first in the literature to a TGCT visualized on post-therapy radioiodine scan.

Spatial interaction between breast cancer and environmental pollution in the Monterrey Metropolitan Area.

This research examines the spatial structure of a sample of breast cancer (BC) cases and their spatial interaction with contaminated areas in the Monterrey Metropolitan Area (MMA). By applying spatial statistical techniques that treat the space as a continuum, degrees of spatial concentration were determined for the different study groups, highlighting their concentration pattern. The results indicate that 65 percent of the BC sample had exposure to more than 56 points of PM10. Likewise, spatial clusters of BC cases of up to 39 cases were identified within a radius of 3.5 km, interacting spatially with environmental contamination sources, particularly with refineries, food processing plants, cement, and metals. This study can serve as a platform for other clinical research by identifying geographic clusters that can help focus health policy efforts.

Spatial Clusters of Children with Cleft Lip and Palate and Their Association with Polluted Zones in the Monterrey Metropolitan Area.

This study examines the spatial structure of children with cleft lip and palate (CLP) and its association with polluted areas in the Monterrey Metropolitan Area (MMA). The Nearest Neighbor Index (NNI) and the Spatial Statistical Scan (SaTScan) determined that the CLP cases are agglomerated in spatial clusters distributed in different areas of the city, some of them grouping up to 12 cases of CLP in a radius of 1.2 km. The application of the interpolation by empirical Bayesian kriging (EBK) and the inverse distance weighted (IDW) method showed that 95% of the cases have a spatial interaction with values of particulate matter (PM10) of more than 50 points. The study also shows that 83% of the cases interacted with around 2000 annual tons of greenhouse gases. This study may contribute to other investigations applying techniques for the identification of environmental and genetic factors possibly associated with congenital malformations and for determining the influence of contaminating substances in the incidence of these diseases, particularly CLP.

Utilización de frío local en el periné como medida analgésica durante el posparto / Use of local cold in the perineum as an analgesic measure during the postpartum period

Objetivo: Determinar la eficacia de la administración de frío local en la región perineal como medida analgésica que pueda usarse con efectividad y seguridad durante el puerperio.Métodos: Se realizó una revisión bibliográfica en las bases de datos PubMed, Cuiden, Cochrane, ClinicalKey y Scielo. Se usaron términos DeCS («crioterapia», «parto», «perineo») y MeSH («cryotherapy», «birth», «perineum»), con el operador booleano «AND». Los criterios de inclusión propuestos admitían documentos publicados en idioma español, inglés o portugués en los últimos 10 años, valorando su calidad metodológica. Como criterio de exclusión se descartaron los estudios realizados en animales y los duplicados.Resultados: En la búsqueda inicial se obtuvo un total de 428 documentos, de los cuales 18 cumplían los criterios propuestos. Tras una lectura crítica, se seleccionó un total de 9 documentos: 5 ensayos clínicos aleatorizados, 1 metaanálisis, 1 ensayo clínico cuasi aleatorizado, 1 caso clínico y 1 revisión sistemática. La mayoría de los documentos revisados concuerdan en que la crioterapia en el periné durante el posparto es una técnica segura que mejora el bienestar de la mujer al disminuir su nivel de dolor.Conclusiones: La administración de frío local en el periné podría disminuir el dolor y los síntomas producidos por el trauma perineal, aumentando de esta manera los niveles de bienestar y satisfacción de las mujeres tras el parto. Sería una alternativa no farmacológica fácilmente utilizable, segura y con bajo coste. Aun así, se necesitan más estudios que confirmen la efectividad de este tratamiento y su seguridad. (AU)

Objective: To determine the efficacy of the administration of local cold in the perineal region as an analgesic measure that can be used effectively and safely during the puerperium.Methods: A bibliographic review was carried out, consulting the PubMed, Cuiden, Cochrane, ClinicalKey and Scielo databases; and the terms DeCS («cryotherapy», «childbirth», «perineum») and MeSH («cryotherapy», «birth», «perineum») were used, using the Boolean operator «AND». The proposed inclusion criteria admitted documents published in Spanish, English or Portuguese, in the last 10 years their methodological quality was assessed. Animal studies were ruled out as exclusion criteria and duplicates.Results: In the initial search, a total of 428 documents were obtained, of which 18 met the proposed criteria. After a critical reading, a total of 9 documents were selected to study: 5 were randomized clinical trials, 1 meta-analysis, 1 quasi-randomized clinical trial, 1 clinical case and 1 systematic review was included. Most of the documents reviewed agree that postpartum cryotherapy in the perineum is a safe technique that improves a woman’s comfort by reducing her level of pain.Conclusions: The administration of local cold in the perineum could reduce the pain and symptoms produced by perineal trauma, thus increasing the levels of comfort and satisfaction of women after childbirth. It would be an easily usable, safe and cheap non-pharmacological alternative. Still, more studies are needed to confirm the effectiveness of this treatment and its safety. (AU)

NGF and nitrosative stress in patients with Huntington's disease.

INTRODUCTION: Huntington's disease (HD) is a neurodegenerative genetic disorder caused by expansion of polyglutamine repeats in the huntingtin gene and characterised by the loss of striatal and cortical neurons. Few studies to date have focussed on peripheral neurotrophic-factor levels in patients with HD. OBJECTIVE: To measure plasma NGF levels in Huntington's disease and investigate their correlation with disease intensity. MATERIALS AND METHODS: Nineteen patients with HD and nineteen age- and sex-matched healthy subjects took part in this cross-sectional study. Plasma levels of NGF, BDNF, GDNF, nitrotyrosine, and myeloperoxidase (MPO) were measured; lactate dehydrogenase (LDH) levels were determined and white blood cell (WBC) counts were evaluated. RESULTS: NGF levels were significantly lower, nitrotyrosine levels were higher and LDH activity was greater in HD patients than in healthy subjects. There was no significant difference in MPO levels or WBC counts, whereas the MPO/WBC ratio was considerably higher in HD patients. The data obtained suggested that biochemical and haematological changes correlated with disease severity. CONCLUSION: NGF levels are lower in HD patients than in healthy subjects. However, further research is required to confirm the role of NGF in HD.

Important role of oxidative stress biomarkers in Huntington's disease.

This study examined global oxidative stress (GOS) and antioxidant system and their correlation with disease stage in 19 patients with HD. The results revealed an increase in oxidative stress biomarkers and a reduction in antioxidant systems in HD patients. The effects were more intense in HD1 than in HD2 patients. Additionally, carbonylated proteins and GOS were correlated with disease stage. These findings suggest that oxidative stress plays an important role in the pathogenesis of HD.