dtiRIM: A generalisable deep learning method for diffusion tensor imaging.

Diffusion weighted MRI is an indispensable tool for routine patient screening and diagnostics of pathology. Recently, several deep learning methods have been proposed to quantify diffusion parameters, but poor generalisation to new data prevents broader use of these methods, as they require retraining of the neural network for each new scan protocol. In this work, we present the dtiRIM, a new deep learning method for Diffusion Tensor Imaging (DTI) based on the Recurrent Inference Machines. Thanks to its ability to learn how to solve inverse problems and to use the diffusion tensor model to promote data consistency, the dtiRIM can generalise to variations in the acquisition settings. This enables a single trained network to produce high quality tensor estimates for a variety of cases. We performed extensive validation of our method using simulation and in vivo data, and compared it to the Iterated Weighted Linear Least Squares (IWLLS), the approach of the state-of-the-art MRTrix3 software, and to an implementation of the Maximum Likelihood Estimator (MLE). Our results show that dtiRIM predictions present low dependency on tissue properties, anatomy and scanning parameters, with results comparable to or better than both IWLLS and MLE. Further, we demonstrate that a single dtiRIM model can be used for a diversity of data sets without significant loss in quality, representing, to our knowledge, the first generalisable deep learning based solver for DTI.

Recurrent inference machines as inverse problem solvers for MR relaxometry.

In this paper, we propose the use of Recurrent Inference Machines (RIMs) to perform T1 and T2 mapping. The RIM is a neural network framework that learns an iterative inference process based on the signal model, similar to conventional statistical methods for quantitative MRI (QMRI), such as the Maximum Likelihood Estimator (MLE). This framework combines the advantages of both data-driven and model-based methods, and, we hypothesize, is a promising tool for QMRI. Previously, RIMs were used to solve linear inverse reconstruction problems. Here, we show that they can also be used to optimize non-linear problems and estimate relaxometry maps with high precision and accuracy. The developed RIM framework is evaluated in terms of accuracy and precision and compared to an MLE method and an implementation of the Residual Neural Network (ResNet). The results show that the RIM improves the quality of estimates compared to the other techniques in Monte Carlo experiments with simulated data, test-retest analysis of a system phantom, and in-vivo scans. Additionally, inference with the RIM is 150 times faster than the MLE, and robustness to (slight) variations of scanning parameters is demonstrated. Hence, the RIM is a promising and flexible method for QMRI. Coupled with an open-source training data generation tool, it presents a compelling alternative to previous methods.