Assuntos
Encefalopatias/psicologia , Face , Alucinações/etiologia , Prosopagnosia/etiologia , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
The Chamorro people of Guam have been afflicted with a complex of neurodegenerative diseases (now known as ALS-PDC) with similarities to ALS, AD, and PD at a far higher rate than other populations throughout the world. Chamorro consumption of flying foxes may have generated sufficiently high cumulative doses of plant neurotoxins to result in ALS-PDC neuropathologies, since the flying foxes forage on neurotoxic cycad seeds.
Assuntos
Esclerose Lateral Amiotrófica/induzido quimicamente , Quirópteros , Cycas/efeitos adversos , Dieta/efeitos adversos , Doença de Alzheimer/induzido quimicamente , Doença de Alzheimer/epidemiologia , Diamino Aminoácidos/efeitos adversos , Esclerose Lateral Amiotrófica/epidemiologia , Animais , Toxinas de Cianobactérias , Cicasina/efeitos adversos , Feminino , Guam/epidemiologia , Humanos , Incidência , Masculino , Havaiano Nativo ou Outro Ilhéu do Pacífico , Doença de Parkinson/epidemiologia , Doença de Parkinson Secundária/induzido quimicamente , Plantas Tóxicas/efeitos adversos , Sementes/efeitos adversosRESUMO
Steele, Richardson and Olszweski in 1964 described a distinctive clinical and pathological entity they called progressive supranuclear palsy (PSP). Now on Guadeloupe in the Carribbean French West Indies, Caparros-Lefebvre is identifying many patients with similar clinical and histological features. Others have a clinical syndrome of atypical parkinsonism that resembles the parkinsonism-dementia complex (PDC) of Guam and the Kii peninsula of Japan (PDC). But in those Pacific foci the histology is different and the abnormal tau is of Alzheimer's type rather than the PSP type of Guadeloupe. In both locales, neurotoxins of local foods are implicated in etiology. Future studies will confirm if Guadeloupean parkinsonism is truly a geographic focus of PSP, and if dietary factors account for both.