Exploring safety and efficacy of rivaroxaban after living donor liver transplantation: a retrospective study.

PURPOSE: Thromboembolic complications remain a significant concern in postoperative patients, particularly those who have undergone liver transplantation. Warfarin has been the standard oral anticoagulant. Direct oral anticoagulants (DOACs) have several advantages over warfarin, including rapid onset of action and standardized dose guidelines. We aimed to assess the safety of rivaroxaban in living donor liver transplantation (LDLT) recipients. METHODS: This study was a single-center, retrospective descriptive analysis of LDLT recipients who received rivaroxaban between December 2020 and April 2022. A total of 27 recipients received rivaroxaban postoperatively. Liver function tests, immunosuppression levels, serum creatinine, and INR were recorded before the initiation of rivaroxaban and then on post-therapy days 1, 7, 14, 28, 90, and 180. RESULTS: Among the 27 recipients receiving rivaroxaban postoperatively, portal venous thrombosis was the most prevalent indication for anticoagulation (44.4%), followed by Budd-Chiari syndrome (29.6%). Nine patients had a twofold increase in either ALT or AST values, two of whom were treated for biliary strictures and the others for rejection. Eighteen patients were given tacrolimus, and eight were on cyclosporine, with one patient switched from tacrolimus to cyclosporine due to insufficient therapeutic levels. There were no incidents of bleeding or re-thrombosis during the 180-day follow-up period. CONCLUSION: Rivaroxaban may be a safe and effective alternative in LDLT recipients with no significant adverse incidents. Further studies with larger sample sizes are needed to confirm these findings and determine this population's optimal dose and duration of rivaroxaban therapy.

Achillon versus open surgery in acute Achilles tendon repair.

BACKGROUND: Open Achilles tendon repairs (OATR) are associated with high complication rates. Minimally invasive surgery (MIS) techniques like the Achillon Achilles tendon repair (AATR) were developed to reduce this. We performed a systematic review and meta-analysis to compare OATR with AATR. METHODS: We performed an extensive literature search including all studies that compared the two techniques. Outcomes assessed included overall complication rate, re-rupture rate, sural nerve injury, wound length, The American Orthopaedic Foot and Ankle Scores (AOFAS) scores and return to sports. RESULTS: Eight studies were suitable for inclusion totalling 210 patients in the AATR group vs 233 patients in the OATR group. Total complication rates were significantly reduced in the Achillon patients with odd ratio of 0.14 (CI 95%, 0.08-0.27, P<0.00001) in favour. There were no significant differences in re-rupture rate, sural nerve injury, return to sports and AOFAS scores following repair between the two groups. CONCLUSIONS: AATR has fewer overall complications compared with OATR. It should be considered as an alternative to open surgical repair.

Factors influencing K-wire migration in tension-band wiring of olecranon fractures.

BACKGROUND: Tension-band wiring is a popular method of internal fixation for simple olecranon fractures. Although fracture union rates and clinical outcomes are good, up to 80% of patients require removal because of prominent/symptomatic metalwork. The current literature remains unclear as to the best orientation of the longitudinal wires to minimize hardware failure. The aim of this study was to determine the surgically modifiable factors related to spontaneous wire pullout. METHODS: A retrospective review of hospital theater records over a period of 6 years was performed to identify all olecranon tension-band wire procedures. Preoperative radiographs were used to confirm and classify the fracture. Intraoperative and postoperative radiographs were analyzed for a number of wire-associated variables: wire length within the ulna, medullary/cortical position, parallelism of wires, proximal wire prominence, wire angle relative to the ulna, distance from the articular surface, fracture gap, and subsequent pullout. RESULTS: A total of 182 wires were analyzed. The mean age was 52.5 years, and the mean radiographic follow-up period was 7.3 months. Intramedullary wires had a mean pullout of 5.5 mm compared with 2.4 mm for transcortical wires (P < .0001). A multiple regression model noted 7 independent variables affecting wire pullout: age, bent wires, medullary/transcortical wire positioning, proximal prominence, ulnar shaft angle, distance from the articular surface, and articular step. CONCLUSION: To minimize postoperative pullout of wires, we suggest anatomic reduction and transcortical wire orientation, without bending, in the subchondral bone close to the articular surface.

Cancerous and Non-Cancerous MRI Classification Using Dual DCNN Approach.

Brain cancer is a life-threatening disease requiring close attention. Early and accurate diagnosis using non-invasive medical imaging is critical for successful treatment and patient survival. However, manual diagnosis by radiologist experts is time-consuming and has limitations in processing large datasets efficiently. Therefore, efficient systems capable of analyzing vast amounts of medical data for early tumor detection are urgently needed. Deep learning (DL) with deep convolutional neural networks (DCNNs) emerges as a promising tool for understanding diseases like brain cancer through medical imaging modalities, especially MRI, which provides detailed soft tissue contrast for visualizing tumors and organs. DL techniques have become more and more popular in current research on brain tumor detection. Unlike traditional machine learning methods requiring manual feature extraction, DL models are adept at handling complex data like MRIs and excel in classification tasks, making them well-suited for medical image analysis applications. This study presents a novel Dual DCNN model that can accurately classify cancerous and non-cancerous MRI samples. Our Dual DCNN model uses two well-performed DL models, i.e., inceptionV3 and denseNet121. Features are extracted from these models by appending a global max pooling layer. The extracted features are then utilized to train the model with the addition of five fully connected layers and finally accurately classify MRI samples as cancerous or non-cancerous. The fully connected layers are retrained to learn the extracted features for better accuracy. The technique achieves 99%, 99%, 98%, and 99% of accuracy, precision, recall, and f1-scores, respectively. Furthermore, this study compares the Dual DCNN's performance against various well-known DL models, including DenseNet121, InceptionV3, ResNet architectures, EfficientNetB2, SqueezeNet, VGG16, AlexNet, and LeNet-5, with different learning rates. This study indicates that our proposed approach outperforms these established models in terms of performance.

Epithelioid hepatic angiomyolipoma in pregnancy: A case report.

INTRODUCTION AND IMPORTANCE: Epithelioid hepatic angiomyolipoma (HAML) is a rare benign tumor predominantly found in women. Its occurrence during pregnancy is extremely rare. Accurate diagnosis of HAML is challenging due to its radiological resemblance to other hepatic neoplasms. We present a case of epithelioid HAML in a pregnant patient, highlighting the diagnostic and management challenges encountered. CASE PRESENTATION: A 24-year-old pregnant female, in her fifth month of pregnancy, presented with right hypochondrium pain and nausea. Radiological imaging suggested the possibility of a hepatic adenoma. The patient opted to continue the pregnancy with regular monitoring of the mass as well as fetal health. After delivering a healthy baby, the patient underwent successful mass excision and cholecystectomy. Histopathology of the liver mass confirmed the diagnosis of epithelioid HAML. CLINICAL DISCUSSION: Epithelioid HAML is a rare tumor often misdiagnosed. It is more aggressive and frequently associated with tuberous sclerosis complex (TSC) compared to other subtypes. The diagnosis of HAML can be challenging due to its resemblance to Hepatocellular Carcinoma and other hepatic neoplasms on radiological imaging. Immunohistochemistry plays a crucial role in confirming the diagnosis. Surgical excision is the recommended treatment, with complete removal to minimize the risk of recurrence. CONCLUSION: This case report highlights the rarity of epithelioid HAML during pregnancy and emphasizes the importance of a multidisciplinary approach in managing hepatic neoplasms. Close monitoring is crucial, considering the potential risks to the mother and fetus. Accurate diagnosis through histopathological evaluation, immunohistochemistry and a multidisciplinary approach are essential for appropriate management.

Multiple Brain Abscesses in an Immunocompetent Patient With Factor V Leiden Mutation.

Multiple brain abscesses in an immunocompetent patient is a challenging clinical problem in the medical world despite advances in imaging techniques, laboratory diagnostics, surgical interventions, and antimicrobial treatment. It is a clinical entity that typically tends to occur in the presence of known predisposing factors. Clinicians seek to determine the potential risk factors responsible for the development of brain abscess because it is very crucial for management of this life-threatening condition. At times, like in our case, there are clinical situations where it is difficult to reveal any traditional risk factors. We report a case of multiple brain abscesses in a 51-year-old female with a past medical history significant only for factor V Leiden mutation, and deep vein thrombosis on chronic anticoagulation. She underwent thorough evaluation but no predisposing factors were found. Based on our extensive literature review, this is the index case of multiple brain abscesses in a patient with history of factor V Leiden mutation and the absence of any conventional risk factors. We also postulate a possible mechanism of infection in such patients.