Detalhe da pesquisa
1.
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.
Cell
; 178(4): 949-963.e18, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31353221
2.
KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Cell
; 168(5): 817-829.e15, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28215705
3.
Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.
Xenobiotica
; 54(2): 64-74, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38197324
4.
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study.
Am J Hematol
; 98(3): 449-463, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594167
5.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35065235
6.
Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias.
PLoS Genet
; 15(6): e1008168, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31199785
7.
Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial.
Blood
; 133(18): 1964-1976, 2019 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30850381
8.
Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models.
Haematologica
; 106(4): 1034-1046, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32414851
9.
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.
Bioorg Med Chem Lett
; 50: 128335, 2021 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34425201
10.
Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models.
Haematologica
; 105(3): 697-707, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31123034
11.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902710
12.
Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.
Nature
; 513(7519): 512-6, 2014 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25043004
13.
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha.
Bioorg Med Chem Lett
; 29(7): 905-911, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30732944
14.
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.
Xenobiotica
; 49(9): 1063-1077, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257601
15.
Flavopiridol enhances ABT-199 sensitivity in unfavourable-risk multiple myeloma cells in vitro and in vivo.
Br J Cancer
; 118(3): 388-397, 2018 02 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29241222
16.
Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker.
Chemistry
; 24(19): 4830-4834, 2018 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29493023
17.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479743
18.
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors.
Proc Natl Acad Sci U S A
; 112(32): E4410-7, 2015 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26216984
19.
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J
; 31(17): 3513-23, 2012 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-22773185
20.
Preclinical efficacy of MEK inhibition in Nras-mutant AML.
Blood
; 124(26): 3947-55, 2014 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25361812