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Gynecol Oncol ; 187: 58-63, 2024 08.
Artigo em Inglês | MEDLINE | ID: mdl-38733953

RESUMO

OBJECTIVES: To evaluate the impact of high-potency topical steroid use on risk of recurrence of lichen sclerosus-associated vulvar cancer. METHODS: This is a retrospective cohort study evaluating patients with lichen sclerosus (LS)- associated vulvar squamous cell cancer (VSCC). Demographic and clinical outcome data were compared between two comparison groups: patients who received steroids, mainly clobetasol, and patients who did not receive steroids following treatment of LS-related vulvar cancer. Categorical variables were compared using Fisher's exact test or chi-square test. Continuous variables were compared using a two-sided student's t-test. Time to recurrence (TTR) and overall survival (OS) were analyzed using Kaplan-Meier survival plot and compared using Mantel-Cox log rank test. Cox proportional hazard regression models were conducted to generate hazard ratios for both TTR and OS. A p value of <0.05 was considered statistically significant. RESULTS: A total of 49 patients were included, with 36 patients receiving steroid treatment and 13 patients in the expectant management group. The median age of diagnosis was 68. The average BMI was 31.7 +/- 7.0. The median length of follow up was 41 months. The majority of patients were diagnosed with stage I VSCC. There was no difference in demographics or oncologic management of vulvar cancer between the two cohorts. Overall recurrence was decreased among patients who received steroid treatment when compared to patients who did not, 12 patients (33.3%) versus 9 patients (69.2%) respectively (p = 0.048). CONCLUSIONS: High-potency topical steroid use following treatment of lichen sclerosus-associated vulvar squamous cell carcinoma is associated with decreased risk of recurrence and prolonged median time to recurrence.


Assuntos
Administração Tópica , Carcinoma de Células Escamosas , Clobetasol , Neoplasias Vulvares , Humanos , Feminino , Neoplasias Vulvares/tratamento farmacológico , Estudos Retrospectivos , Idoso , Pessoa de Meia-Idade , Clobetasol/administração & dosagem , Carcinoma de Células Escamosas/tratamento farmacológico , Carcinoma de Células Escamosas/patologia , Idoso de 80 Anos ou mais , Líquen Escleroso Vulvar/tratamento farmacológico , Recidiva Local de Neoplasia/tratamento farmacológico , Estudos de Coortes , Resultado do Tratamento , Adulto , Líquen Escleroso e Atrófico/tratamento farmacológico
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