Detalhe da pesquisa
1.
Haemagglutinin substitutions N125D, D127E, D222G and R223Q improve replicative fitness and vaccine effectiveness of an A/H1N1pdm09 live attenuated influenza vaccine virus by enhancing α-2,6 receptor binding.
PLoS Pathog
; 18(5): e1010585, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35622874
2.
Sequential Delivery of Live Attenuated Influenza Vaccine and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Ferret Model Can Reduce SARS-CoV-2 Shedding and Does Not Result in Enhanced Lung Pathology.
J Infect Dis
; 225(3): 404-412, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34893851
3.
Defining the root cause of reduced H1N1 live attenuated influenza vaccine effectiveness: low viral fitness leads to inter-strain competition.
NPJ Vaccines
; 6(1): 35, 2021 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33712628
4.
Imidazolylmethylbenzophenones as highly potent aromatase inhibitors.
J Med Chem
; 50(15): 3420-2, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17585752
5.
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
J Med Chem
; 51(24): 8077-87, 2008 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-19049427
6.
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
J Med Chem
; 51(19): 6138-49, 2008 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18763754
7.
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
J Med Chem
; 51(16): 5064-74, 2008 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18672861